DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt301D1 and Ugt2a1

DIOPT Version :9

Sequence 1:	NP_001246079.1	Gene:	Ugt301D1 / 35105	FlyBaseID:	FBgn0032684	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	XP_038948318.1	Gene:	Ugt2a1 / 63867	RGDID:	69432	Length:	528	Species:	Rattus norvegicus

Alignment Length:	526	Identity:	153/526 - (29%)
Similarity:	250/526 - (47%)	Gaps:	61/526 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 MLIFLIGLLEFGAGSRILFMGPFPAP-SHWLWLEHFQNDLLRQGHHVT--------SVNNHP--- 63
            :|||.:.|.|......::.   :|:. ||||.::....:|:::.|.||        .:|:.|
  Rat     8 LLIFPLALTEIVLSGNVVI---WPSDGSHWLNIKILLEELVQRNHSVTVLAASETLFINSSPDAF 69

  Fly    64 ----------TKHPHENLTEIIISPSFDIPKHFPKENIFSMQFVSDFNNL-ELWWTIGLMTTEHA 117
                      |:...:.:.|.:|:...|   |.|.. :....|..:...| ..::.|.....:..
  Rat    70 ISFEEIPVSYTRSKIDEMIEHMIALWLD---HRPTP-LTMWAFYKELGKLFAAFYKINKQICDGV 130

  Fly   118 FKDPKVKKLIESKDDHYDLVIIEQFFHEAFLMFGK----RFNCPVVTIGTMGYADNID-HAMGIL 177
            .|:..:...::.  ..:|::|     .:...|.|:    :...|.|.......|..:: |...|.
  Rat   131 LKNATLMARLQK--GGFDVLI-----SDPVTMCGELVALKLGIPFVYTLRFSPAFTVERHCGKIP 188

  Fly   178 TPWSLIPHLLLSHTDRMTFGQRAYNAY-LSLYDAVMR----RWVYLPKMQKLAEKYFQGSIEGPL 237
            ||.|.:|..|...||:||||:|..|.. .||.|.:.:    .|          ..|:...:..|
  Rat   189 TPVSYVPAALSELTDQMTFGERVKNTISYSLQDYIFKSYWGEW----------NSYYSRVLGRP- 242

  Fly   238 PNVLDLERNISLVLINAHRSIDLPRPSMPGLIDVGGAHIQKPKQLPTDLQNFLD-NATYGVIYFS 301
            ..:.:......:.|:..:...:.|||.:|....|||.|.:..|.||.:::.|:. :..:||:.||
  Rat   243 TTLCETMGKAEIWLMRTYWDFEFPRPYLPNFEFVGGLHCKPAKPLPKEMEEFVQTSGEHGVVVFS 307

  Fly   302 MGSYVKSTDLPQEKTALILKAFGQLKQQVIWKFENDSIGDLPSNVMIKKWMPQNDILAHPNVKLF 366
            :||.||  :|.:||..||..|..|:.|:|:|:::......|.||..:..|:||||:|.||..:.|
  Rat   308 LGSMVK--NLTEEKANLIASALAQIPQKVLWRYKGKIPATLGSNTRLFDWIPQNDLLGHPKTRAF 370

  Fly   367 ITHGGIFGTQEGIYWGVPMLCVPLYGDQHRNTIKSVREGYARSLVFSKLTTDDLVRNIETLINDP 431
            |||||..|..|.||.|:||:.||::.||..|......:|.|..:..:.:|:.||:..:..:||:|
  Rat   371 ITHGGTNGIYEAIYHGIPMVGVPMFADQPDNIAHMKAKGAAVEVNMNTMTSADLLSAVRAVINEP 435

  Fly   432 QYKRSALEVSQRFRDNPIHPLDEATFWIEYIIRHRGARHLKSHGAFIPLHQYLLLDVLGCLLLGA 496
            .||.:|:.:|:...|.|:.|||.|.||||:::||:||:||:.....:...||..|||:|.||...
  Rat   436 FYKENAMRLSRIHHDQPVKPLDRAVFWIEFVMRHKGAKHLRVAAHDLSWFQYHSLDVIGFLLACM 500

  Fly   497 FLAIWL 502
            ..||.|
  Rat   501 ASAILL 506

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt301D1	NP_001246079.1	egt	12..483	CDD:223071	142/504 (28%)
Ugt301D1	NP_001246079.1	UDPGT	37..483	CDD:278624	136/478 (28%)
Ugt2a1	XP_038948318.1	UDPGT	22..524	CDD:278624	148/512 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	256	1.000	Domainoid score	I1959
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	275	1.000	Inparanoid score	I2882
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm9018
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.860