DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt301D1 and Ugt1a8

DIOPT Version :9

Sequence 1:	NP_001246079.1	Gene:	Ugt301D1 / 35105	FlyBaseID:	FBgn0032684	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_001365304.1	Gene:	Ugt1a8 / 613123	MGIID:	3576090	Length:	530	Species:	Mus musculus

Alignment Length:	541	Identity:	158/541 - (29%)
Similarity:	265/541 - (48%)	Gaps:	66/541 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 CWMLIFLIGLLEFGAGSRILFMGPFPAPSHWLWLEHFQNDLLRQGHHVTSVNNHPTKH--PHENL 71
            |.:|.|  ||.:.|   |:|.: |... |||..::.....|..:||.|..|....:.|  ..:|.
Mouse    15 CLLLAF--GLAQAG---RLLVV-PMDG-SHWFSMKMIVEKLSHRGHEVVVVIPEVSWHLGKSQNF 72

  Fly    72 TEIIISPSF---DIPKHFPKENIFSMQFVSDFNNLELWWTIGLMT-TEHA--------------- 117
            |....|.|:   |:..||   |.|:.:   .:.|.|    :|:.: .:|:
Mouse    73 TVKTYSVSYTLEDLSHHF---NFFAHK---QWENRE----VGMFSLLKHSGKGFFQVLFSHCRSL 127

  Fly   118 FKDPKVKKLIE-SKDDHYDLVIIEQFFHEAFLMFGKRFNCPVVTIGTMGYADNIDHAMGILTPWS 181
            |.|   |||:| .|...:|.|.::. |....|...|.|:.|.|......:...:|......:|.|
Mouse   128 FND---KKLVEYLKQRSFDAVFLDP-FDVCGLTIAKYFSLPSVVFSGGIFCHYLDEGAQCPSPPS 188

  Fly   182 LIPHLLLSHTDRMTFGQRAYNAYLSLYDAVMRRWVYLPKMQKLAEKYFQGSIEGPLPNVLDLERN 246
            .:|.:|....|.|||.:|.:|     |.:.|:...:.|...|.|.:.....::.|: .:.||..:
Mouse   189 YVPRILSKFADTMTFKERVWN-----YFSYMKERAFCPYFFKTAIEIASEVLQTPV-TMTDLFSS 247

  Fly   247 ISLVLINAHRSIDLPRPSMPGLIDVGGAHIQKPKQLPTDLQNFLD-NATYGVIYFSMGSYVKSTD 310
            :|:.:......::.|||.||.::.:||.:....|.|..:.:.::: :..:|::.||:||.|  ::
Mouse   248 VSIWMFRTDFVLEFPRPVMPNMVYIGGINCHPGKPLSKEFEAYVNASGEHGIVVFSLGSMV--SE 310

  Fly   311 LPQEKTALILKAFGQLKQQVIWKFENDSIGDLPSNVMIKKWMPQNDILAHPNVKLFITHGGIFGT 375
            :|::|...|.:|.|::.|.|:|::......:|..|.::.||:||||:|.||..:.||||.|..|.
Mouse   311 IPEKKAMEIAEALGRIPQTVLWRYTGTRPSNLAKNTILVKWLPQNDLLGHPKTRAFITHSGSHGI 375

  Fly   376 QEGIYWGVPMLCVPLYGDQHRNTIKSVREGYARSLVFSKLTTDDLVRNIETLINDPQYKRSALEV 440
            .|||..||||:.:||:|||..|..:....|...:|...::|.|||...::|:||:..||.:.:.:
Mouse   376 YEGICNGVPMVMMPLFGDQMDNAKRMETRGAGVTLNVLEMTADDLENALKTVINNKSYKENIMRL 440

  Fly   441 SQRFRDNPIHPLDEATFWIEYIIRHRGARHLKSHGAFIPLHQYLLLDVLGCLLLGAFLAIWLPWR 505
            |...:|.||.|||.|.||:||::||:||.||:.....:..:||..|||:|.||......:::.::
Mouse   441 SSLHKDRPIEPLDLAVFWVEYVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAIVLTVVFIVFK 505

  Fly   506 --------------MIRRVHK 512
                          .:::.||
Mouse   506 CCAYGCRKCFGGKGRVKKSHK 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt301D1	NP_001246079.1	egt	12..483	CDD:223071	147/493 (30%)
Ugt301D1	NP_001246079.1	UDPGT	37..483	CDD:278624	139/468 (30%)
Ugt1a8	NP_001365304.1	UDPGT	26..521	CDD:278624	151/521 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	259	1.000	Domainoid score	I1975
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	272	1.000	Inparanoid score	I2975
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm42461
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.760