Protein Alignment Ugt301D1 and UGT2A2

DIOPT Version :10

• Sequence 1: NP_609882.1
• Gene: Ugt301D1 / 35105
• FlyBaseID: FBgn0032684
• Length: 530
• Species: Drosophila melanogaster
• Sequence 2: NP_001099147.2
• Gene: UGT2A2 / 574537
• HGNCID: 28183
• Length: 536
• Species: Homo sapiens
• Alignment Length: 530
• Identity: 162/530 - (30%)
• Similarity: 258/530 - (48%)
• Gaps: 69/530 - (13%)

  Fly    11 MLIFLIGLLEFGAGSRILFMGPFPAP-SHWLWLEHFQNDLLRQGHHVTSVNNHPTKHPHENLTEI 74
            ||:|.:.|.|......:|.   :|.. ||||.::....:|:::.|:||.:.:..|...:.|..
Human    16 MLVFNLTLTEVVLSGNVLI---WPTDGSHWLNIKIILEELIQRNHNVTVLASSATLFINSNPD-- 75

  Fly    75 IISP-SFD-IPKHFPKENIFSM-------------------QFVSDFNN-LELWWTIGLMTTEHA 117
              || :|: ||..:.|.||.|:                   .|..:... |:.::.|.:...:..
Human    76 --SPVNFEVIPVSYKKSNIDSLIEHMIMLWIDHRPTPLTIWAFYKELGKLLDTFFQINIQLCDGV 138

  Fly   118 FKDPKVKKLIESKDDHYDLVIIEQFFHEAFL---------MFGKRFNCPVVTIGTMGYADNIDHA 173
            .|:||:...::.  ..:|:::.:.......|         |:..||: |..|:..        |.
Human   139 LKNPKLMARLQK--GGFDVLVADPVTICGDLVALKLGIPFMYTLRFS-PASTVER--------HC 192

  Fly   174 MGILTPWSLIPHLLLSHTDRMTFGQRAYNAY-LSLYDAVMR----RWVYLPKMQKLAEKYFQGSI 233
            ..|..|.|.:|..|...||:||||:|..|.. .||.|.:.:    .|          ..|: ..|
Human   193 GKIPAPVSYVPAALSELTDQMTFGERIKNTISYSLQDYIFQSYWGEW----------NSYY-SKI 246

  Fly   234 EGPLPNVLDLERNISLVLINAHRSIDLPRPSMPGLIDVGGAHIQKPKQLPTDLQNFLDNA-TYGV 297
            .|....:.:......:.||..:...:.|||.:|....|||.|.:..|.||.:::.|:.:: ..||
Human   247 LGRPTTLCETMGKAEIWLIRTYWDFEFPRPYLPNFEFVGGLHCKPAKPLPKEMEEFIQSSGKNGV 311

  Fly   298 IYFSMGSYVKSTDLPQEKTALILKAFGQLKQQVIWKFENDSIGDLPSNVMIKKWMPQNDILAHPN 362
            :.||:||.||  :|.:||..||..|..|:.|:|:|:::......|.:|..:..|:||||:|.||.
Human   312 VVFSLGSMVK--NLTEEKANLIASALAQIPQKVLWRYKGKKPATLGNNTQLFDWIPQNDLLGHPK 374

  Fly   363 VKLFITHGGIFGTQEGIYWGVPMLCVPLYGDQHRNTIKSVREGYARSLVFSKLTTDDLVRNIETL 427
            .|.||||||..|..|.||.||||:.||::.||..|......:|.|..:..:.:|:.||:..:.|:
Human   375 TKAFITHGGTNGIYEAIYHGVPMVGVPMFADQPDNIAHMKAKGAAVEVNLNTMTSVDLLSALRTV 439

  Fly   428 INDPQYKRSALEVSQRFRDNPIHPLDEATFWIEYIIRHRGARHLKSHGAFIPLHQYLLLDVLGCL 492
            ||:|.||.:|:.:|:...|.|:.|||.|.||||:::||:||:||:.....:...||..|||:|.|
Human   440 INEPSYKENAMRLSRIHHDQPVKPLDRAVFWIEFVMRHKGAKHLRVAAHDLTWFQYHSLDVIGFL 504

  Fly   493 LLGAFLAIWL 502
            |:....||:|
Human   505 LVCVTTAIFL 514

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt301D1	NP_609882.1	Glycosyltransferase_GTB-type	37..483	CDD:471961	144/482 (30%)
UGT2A2	NP_001099147.2	UDPGT	30..524	CDD:278624	157/516 (30%)