DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt301D1 and ugt5g1

DIOPT Version :9

Sequence 1:	NP_001246079.1	Gene:	Ugt301D1 / 35105	FlyBaseID:	FBgn0032684	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_001107914.1	Gene:	ugt5g1 / 570913	ZFINID:	ZDB-GENE-080305-10	Length:	528	Species:	Danio rerio

Alignment Length:	536	Identity:	162/536 - (30%)
Similarity:	262/536 - (48%)	Gaps:	64/536 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MEMQLQWKCWMLIFLIGLLEFGAGSRILFMGPFPAP-SHWLWLEHFQNDLLRQGHHVTSVNNHPT 64
            |:|..:|.. .|..|:.::....|..||.   ||.. |||:.::.....|...||..|.|.:..:
Zfish     1 MDMSSKWLS-ALTCLLSVVCCCHGGNILV---FPEDGSHWVNMQVILRKLHTHGHSFTVVRSSKS 61

  Fly    65 KHPHEN---LTEIIISP-----------------SFDIPKHFPKENIFSMQ-----FVSDFNNLE 104
            .:.|||   ...|.::|                 |..:.|..|....|..|     .:..|:|
Zfish    62 WYIHENSALYNTITVNPVETEDVGQDYFNMLLDRSLALQKMSPLVRFFEQQKDITTVLKVFHN-- 124

  Fly   105 LWWTIGLMTTEHAFKDPK--VKKLIESKDDHYDLVIIEQFFHEA-----FLMFGKRFNCPVVTIG 162
                 |::....|..|..  ||.|.|:|   :||::.:..|...     ||.....:|...:..|
Zfish   125 -----GVLRMVSAMLDDAELVKSLREAK---FDLLLTDPAFPAGVLVANFLQLPMVYNVRWLNAG 181

  Fly   163 TMGYADNIDHAMGILTPWSLIP-HLLLSHTDRMTFGQRAYNAYLSLYDAVMRRWVYLPKMQKLAE 226
            ..       |.....:|.|.:| :..|.| |:|:|.||..|....|...:..|:|.:|..::|.|
Zfish   182 DA-------HMQTAPSPPSYVPMYNSLLH-DQMSFLQRVENFLRYLCSLLQERYVIVPIYRELLE 238

  Fly   227 KYFQGSIEGPLPNVLDLERNISLVLINAHRSIDLPRPSMPGLIDVGGAHIQKPKQLPTDLQNFLD 291
            ::|.     |..::|.::::..:.|:......|.|||:||.:|.:||...:..:.||.||:.|:.
Zfish   239 RHFP-----PGSDLLSMQQSADIWLMRMDFVFDFPRPTMPNIIYMGGFQCKPAQALPVDLEEFMQ 298

  Fly   292 NA-TYGVIYFSMGSYVKSTDLPQEKTALILKAFGQLKQQVIWKFENDSIGDLPSNVMIKKWMPQN 355
            :: .:||::.|:|:.|.:  ||:..|..|..||.::.|:|:|::..:....|.:|.::.:|.|||
Zfish   299 SSGEHGVVFMSLGAMVGA--LPRTITEAIASAFAKIPQKVMWRYHGERPSTLGNNTLLLEWFPQN 361

  Fly   356 DILAHPNVKLFITHGGIFGTQEGIYWGVPMLCVPLYGDQHRNTIKSVREGYARSLVFSKLTTDDL 420
            |:|.||..:.|::|||..|..|.||.|||:|.:||..||..|.::......||.|..:.||:.:.
Zfish   362 DLLGHPKTRAFVSHGGTNGIYEAIYHGVPVLALPLLFDQFDNVMRLQVRNAARVLQVATLTSQEF 426

  Fly   421 VRNIETLINDPQYKRSALEVSQRFRDNPIHPLDEATFWIEYIIRHRGARHLKSHGAFIPLHQYLL 485
            :..::.::.:|.|:.|..::|:..||.||.|||.|||||||::||:||.||:|....:..:.|..
Zfish   427 LEGLKDVLENPLYRSSIRKMSELHRDQPISPLDSATFWIEYVMRHKGAAHLRSEANNLAWYSYHS 491

  Fly   486 LDVLGCLLLGAFLAIW 501
            ||||..||..|.:|.|
Zfish   492 LDVLVFLLAIAVIAFW 507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt301D1	NP_001246079.1	egt	12..483	CDD:223071	149/505 (30%)
Ugt301D1	NP_001246079.1	UDPGT	37..483	CDD:278624	142/479 (30%)
ugt5g1	NP_001107914.1	UDPGT	24..526	CDD:278624	156/512 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	252	1.000	Domainoid score	I2043
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	252	1.000	Inparanoid score	I3189
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm6444
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.860