DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt301D1 and ugt5g2

DIOPT Version :9

Sequence 1:	NP_001246079.1	Gene:	Ugt301D1 / 35105	FlyBaseID:	FBgn0032684	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_001186305.1	Gene:	ugt5g2 / 556049	ZFINID:	ZDB-GENE-081028-66	Length:	534	Species:	Danio rerio

Alignment Length:	549	Identity:	154/549 - (28%)
Similarity:	254/549 - (46%)	Gaps:	98/549 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 CWMLIFLIG--LLEFGAG---SRILFMGPFPAP-SHWLWLEHFQNDLLRQGHHVTSVNNHPTKHP 67
            |..|:||..  ||...:|   .:||.   ||.. |||:.:|.....|..:||
Zfish     4 CMSLVFLWTSLLLSLPSGYNADKILV---FPIDGSHWVNMEVLVKKLQSRGH------------- 52

  Fly    68 HENLTEIIISPSFDIPKHFPKENIFSMQFVSDFNNLELWWT------------------------ 108
              .|:.|.:..|:.|..:.|..:..::.....|.:|:|:.|
Zfish    53 --ELSVIRLEDSWFIKGNSPYYSSITVTLKKKFIDLDLFETAVKKILDARRDGPIMGVLAQMSEF 115

  Fly   109 IGLMTTEHAFKDPKVKKLIES-------KDDHYDL----------VIIEQFFHEAFLMFGKRFNC 156
            ||::...|......:..::|:       |..:|||          ||:..:.|           .
Zfish   116 IGILKVGHGANIAMLTSMLENKVLMSQIKMANYDLMLTDPAMPGGVILAHYLH-----------L 169

  Fly   157 PVV-TIGTMGYADNIDHAMGILTPWSLIPHLLLSHTDRMTFGQRAYNAYLSLYDAVMRRWVYLPK 220
            |:| .:..|.:.:.  |.....:|.|.:|......||||...:|:.|......:.:..||:.:|.
Zfish   170 PMVYNVRWMSFGEG--HFSIAPSPISFVPVPGSGLTDRMGLLERSRNFLHYGLNLIQERWMVIPM 232

  Fly   221 MQKLAEKYFQGSIEGPLPNVLDLERNISLVLINAHRSIDLPRPSMPGLIDVGGAHIQKPKQLPTD 285
            ...|...:|.     |..::|.::|:..|.|:.|....:.||||||.|:.:||...:..|.||.|
Zfish   233 YTSLLLNHFP-----PGTDLLTMQRSAELWLVRADFVFEFPRPSMPNLVYIGGFQCRPAKPLPAD 292

  Fly   286 LQNFLDNA-TYGVIYFSMGSYVKSTDLPQEKTALILKAFGQLKQQVIWKFENDSIGDLPS----N 345
            |:.|:.:: .:||:..|:|:.:  ..||:|....|..||.|:.|:|||:|    ||..||    |
Zfish   293 LEEFMQSSGDHGVVVMSLGTLI--AGLPKEVMEAIASAFAQIPQKVIWRF----IGQRPSTLGNN 351

  Fly   346 VMIKKWMPQNDILAHPNVKLFITHGGIFGTQEGIYWGVPMLCVPLYGDQHRNTIKSVREGYARSL 410
            .::.:|:||||:|.||..:.|:.|||..|..|.||.|||:|.:||..||..|.::....|.||.|
Zfish   352 TLLIQWLPQNDLLGHPKTRAFVAHGGTNGLYEAIYHGVPVLGLPLLFDQLDNIVRLQARGGARML 416

  Fly   411 VFSKLTTDDLVRNIETLINDPQYKRSALEVSQRFRDNPIHPLDEATFWIEYIIRHRGARHLKSHG 475
            ..:..:|.:.:..:..::.:|.|:::..::|...||.|:||||:|.:|||:::|::||.||::..
Zfish   417 DAATCSTKEFLVALTDILENPTYRQNMQKLSNLHRDRPLHPLDKAVYWIEFVLRNKGAPHLRAEA 481

  Fly   476 AFIPLHQYLLLDVLGC---LLLGAFLAIW 501
            ..:....|..|||:..   :|||....::
Zfish   482 YNVSEFSYYCLDVVALVLFMLLGTLGGVY 510

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt301D1	NP_001246079.1	egt	12..483	CDD:223071	146/523 (28%)
Ugt301D1	NP_001246079.1	UDPGT	37..483	CDD:278624	136/492 (28%)
ugt5g2	NP_001186305.1	egt	3..507	CDD:223071	154/544 (28%)
ugt5g2	NP_001186305.1	UDPGT	25..513	CDD:278624	147/528 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	252	1.000	Domainoid score	I2043
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	252	1.000	Inparanoid score	I3189
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm6444
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.760