DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt301D1 and ugt2a2

DIOPT Version :9

Sequence 1:	NP_001246079.1	Gene:	Ugt301D1 / 35105	FlyBaseID:	FBgn0032684	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_001018306.2	Gene:	ugt2a2 / 553952	ZFINID:	ZDB-GENE-080721-21	Length:	534	Species:	Danio rerio

Alignment Length:	567	Identity:	157/567 - (27%)
Similarity:	252/567 - (44%)	Gaps:	118/567 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 KCWM------LIFLIGLLEFGAGSRILFMGPFPAPSHWLWLEHFQNDLLRQGHHVTSV--NNHPT 64
            ||.:      |||:.....  ||:.::..|.:   |||..:.:..::||.:.|.||.:  :..||
Zfish     3 KCLLKPSPLVLIFIFSFTH--AGNVLVLPGEY---SHWQNMRNVVDELLNRNHTVTVLVCSASPT 62

  Fly    65 KH--PHENLTEIIISPSFDIPKHFPKENIFSMQFVSDFNN--LELWWTIGLMTTEHAFKDPKVKK 125
            .:  ..|....::    |::|        .|.|.:...:.  :.:|       |:|    |...:
Zfish    63 INFTQQERFQYLV----FEVP--------LSAQELDGASEELIHIW-------TQH----PSPNR 104

  Fly   126 LIESKDDHYDLVIIE-----QFFHEAF----------------LMFGKRFNCPVVTIGTMGYADN 169
            |..:      |.|||     :..|.|.                |.|...||.|:...     ||.
Zfish   105 LQTA------LQIIELLGRVRVMHRAMCDSMLRNDALIAQLSALKFDVLFNDPMFMC-----ADL 158

  Fly   170 IDHAMGI---------------------LTPWSLIPHLLLSHTDRMTFGQRAYNAYLSLYDAV-- 211
            :...:|:                     ..|.|.:|......||||.|.:|..|...::..:|
Zfish   159 LAEMLGLPLVLSVRISPGFCLERMCGQMPAPPSFVPITQTVLTDRMCFMERVQNMIANIVFSVSF 223

  Fly   212 -MRRWVYLPKMQKLAEKYFQGSIEGPLPNVLDLERNISLVLINAHRSIDLPRPSMPGLIDVGGAH 275
             :..|:.|       :.|:. .:.|....:.:......:.||..:...:.|||..|....|||.|
Zfish   224 YIVAWISL-------DSYYT-DVLGKPTTMCETMGKADIWLIRTYWDFEYPRPFPPNFKFVGGLH 280

  Fly   276 IQKPKQLPTDLQNFLDNA-TYGVIYFSMGSYVKSTDLPQEKTALILKAFGQLKQQVIWKFENDSI 339
            .:..|.|..:::.|:.:: .:||:.||:||.:|  :|..|:...|..|.||:.|:|:|::...:.
Zfish   281 CKPAKPLSKEMEEFVQSSGDHGVVVFSLGSMIK--NLTSERANTIAAALGQIPQKVVWRYSGKTP 343

  Fly   340 GDLPSNVMIKKWMPQNDILAHPNVKLFITHGGIFGTQEGIYWGVPMLCVPLYGDQHRNTIKSVRE 404
            ..|..|..|..|:||||:|.||..|.||||||..|..|.||.||||:.:||:.||..|.:....:
Zfish   344 ETLAPNTKIYDWIPQNDLLGHPKTKAFITHGGTNGLYEAIYHGVPMVGLPLFADQPDNLLHMKTK 408

  Fly   405 GYARSLVFSKLTTDDLVRNIETLINDPQYKRSALEVSQRFRDNPIHPLDEATFWIEYIIRHRGAR 469
            |.|..|..:.|.:.|||..::|::|:|.||.|.:.:|:...|.|:.|||:|.:|||:::|::||:
Zfish   409 GAAVVLDINTLESKDLVDALKTVLNNPSYKESIMRLSRIHHDQPMKPLDQAVYWIEFVMRNKGAK 473

  Fly   470 HLKSHGAFIPLHQYLLLDVLGCLLLGAFLAIWLPWRMIRRVHKWWLK 516
            ||:.....:..:||..|||...||..|.|..:|           |:|
Zfish   474 HLRVQAHELSWYQYHCLDVAAFLLSIAALITFL-----------WVK 509

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt301D1	NP_001246079.1	egt	12..483	CDD:223071	143/522 (27%)
Ugt301D1	NP_001246079.1	UDPGT	37..483	CDD:278624	137/497 (28%)
ugt2a2	NP_001018306.2	UDPGT	23..521	CDD:278624	151/545 (28%)
ugt2a2	NP_001018306.2	egt	<256..487	CDD:223071	88/232 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	252	1.000	Domainoid score	I2043
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	252	1.000	Inparanoid score	I3189
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm6444
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.860