DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt301D1 and ugt8

DIOPT Version :9

Sequence 1:	NP_001246079.1	Gene:	Ugt301D1 / 35105	FlyBaseID:	FBgn0032684	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_001037790.2	Gene:	ugt8 / 553508	ZFINID:	ZDB-GENE-060616-129	Length:	541	Species:	Danio rerio

Alignment Length:	540	Identity:	154/540 - (28%)
Similarity:	255/540 - (47%)	Gaps:	86/540 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 SRILFMGPFPAPSHWLWLEHFQNDLLRQGHHVTSVNNHPTKHPHENLTEIIISPSFDIPKHFPKE 89
            ::|:.:.|....||....:...:.|..:||.                |..::|...:||   |..
Zfish    22 AKIVVVPPIMFESHLYIFKTLASALHAEGHD----------------TVFLVSEGREIP---PSN 67

  Fly    90 NIFSMQFVSDFNNLELWWTIGLMTTEHAFKDPKVKKL-------IESKD--DHY----DLV---- 137
            :....::...||:          |:...|...||:.:       :|..|  |||    |.|
Zfish    68 HYRLQRYPGIFNS----------TSADDFLQSKVRNIFSGRLTALELFDILDHYSQNCDAVVGST 122

  Fly   138 -IIEQFFHEAF--LMFGKRFNCPVVTIGTMGYADNIDHA-----------MGILTPWSLIPHLLL 188
             ::||...|.|  |:......|..|....:|    :.:|           :|...|.|.:|....
Zfish   123 SVMEQLKREHFDLLLVDPNEMCGFVIAHILG----VQYAVFSTGLWYPAEVGAPAPLSYVPEFNS 183

  Fly   189 SHTDRMTFGQRAYNAYLSLYDAVMRRWVYLPKMQKLAEKYFQGSIEGPLPNVLDLERNISLVLIN 253
            ..||.|:..||..|..:.|......:::.|||..::..||   :|: |..::.||.:|..|.::.
Zfish   184 LLTDHMSLFQRVANTAVYLVSRFGVQFLVLPKYDRIMRKY---NIQ-PSVSMHDLVQNSRLWMLC 244

  Fly   254 AHRSIDLPRPSMPGLIDVGGAHIQKPKQLPTDLQNFL-DNATYGVIYFSMGSYVK--STDLPQEK 315
            ...:::.|||::|.::.|||...:.|..||.:.:.:: |....|.:..|.|:.||  |.|:.|:
Zfish   245 TDMALEFPRPTLPHVVYVGGILTKPPSPLPQEFETWVKDTDEDGFVVVSFGAGVKYLSDDIAQK- 308

  Fly   316 TALILKAFGQLKQQVIWKFENDSIGDLPSNVMIKKWMPQNDILAHPNVKLFITHGGIFGTQEGIY 380
               :..|..:|.|:|||:|......:|.:|..:..||||||:|...|.:.|::|||:....|.:|
Zfish   309 ---LAGALSRLPQRVIWRFSGVPPSNLGNNTKLVDWMPQNDLLGQTNTRAFLSHGGLNSIYEAMY 370

  Fly   381 WGVPMLCVPLYGDQHRNTIKSVR-EGYARSLVFSKLTTDDLVRNIETLINDPQYKRSALEVSQRF 444
            .|||::.|||:|| |.:|:..|: :|....|.:.:::.:||...:..:|.|.:|:..|..:||..
Zfish   371 HGVPVVGVPLFGD-HYDTMTRVQAKGMGIMLEWKRMSEEDLYTAMVNVITDKRYRERAQLLSQIH 434

  Fly   445 RDNPIHPLDEATFWIEYIIRHRGARHLKSHGAFIPLHQYLLLD---VLG-CLLLGAFLAIWLPWR 505
            :|.|.||:..|.:||.||:|||||.||:|....||.:||.|||   |:| ||||..:..    :|
Zfish   435 KDQPGHPVSRAVYWISYILRHRGAEHLRSAVYEIPTYQYFLLDVAMVIGVCLLLTGYCL----YR 495

  Fly   506 MIRRVHKWWLKGES-SNKLN 524
            :::.:.....:|.| ..|:|
Zfish   496 IVKFIQFRLGRGSSPGEKVN 515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt301D1	NP_001246079.1	egt	12..483	CDD:223071	138/492 (28%)
Ugt301D1	NP_001246079.1	UDPGT	37..483	CDD:278624	136/480 (28%)
ugt8	NP_001037790.2	UDPGT	22..500	CDD:330975	150/523 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	252	1.000	Domainoid score	I2043
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm6444
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.810