Protein Alignment Ugt301D1 and UGT1A3

DIOPT Version :10

• Sequence 1: NP_609882.1
• Gene: Ugt301D1 / 35105
• FlyBaseID: FBgn0032684
• Length: 530
• Species: Drosophila melanogaster
• Sequence 2: NP_061966.1
• Gene: UGT1A3 / 54659
• HGNCID: 12535
• Length: 534
• Species: Homo sapiens
• Alignment Length: 566
• Identity: 150/566 - (26%)
• Similarity: 263/566 - (46%)
• Gaps: 94/566 - (16%)

  Fly     1 MEMQLQWKCWMLIFLIGLLEFGAGSRILFMGPFPAPSHWLWLEHFQNDLLRQGHHVTSVNNHPTK 65
            :::.|.|....|:.|:.:..:....::|.: |... ||||.:.....:|..:||..
Human     5 LQVPLPWLATGLLLLLSVQPWAESGKVLVV-PIDG-SHWLSMREVLRELHARGHQA--------- 58

  Fly    66 HPHENLTEIIISPSFDIPKHFPKENIFSMQFVS------DFNNLELWWTIGLMTTEHAFKD-PKV 123
                    ::::|  ::..|..:||.|::...:      :|:...|..|.....|||..|. .:.
Human    59 --------VVLTP--EVNMHIKEENFFTLTTYAISWTQDEFDRHVLGHTQLYFETEHFLKKFFRS 113

  Fly   124 KKLIESKDDHYDLVIIEQFFHEAFL------MFGKRFNCPV----------VTIGTMGYADNIDH 172
            ..::.:....|....:|...:||.:      .|......||          ::|.|:.:..||..
Human   114 MAMLNNMSLVYHRSCVELLHNEALIRHLNATSFDVVLTDPVNLCAAVLAKYLSIPTVFFLRNIPC 178

  Fly   173 AMGIL-----TPWSLIPHLLLSHTDRMTFGQRAYNAYLSLYDAVMRRWVYLPKMQKLAEKYFQGS 232
            .:...     .|.|.||.||.:::|.|||.||..|   .||              .||..|...:
Human   179 DLDFKGTQCPNPSSYIPRLLTTNSDHMTFMQRVKN---MLY--------------PLALSYICHA 226

  Fly   233 IEGPLPNVLD--LERNISLVLINAHRSI---------DLPRPSMPGLIDVGGAHIQKPKQLPTDL 286
            ...|..::..  .:|.:|:|.|.:|.|:         |.|||.||.::.:||.:....|.|..:.
Human   227 FSAPYASLASELFQREVSVVDILSHASVWLFRGDFVMDYPRPIMPNMVFIGGINCANRKPLSQEF 291

  Fly   287 QNFLD-NATYGVIYFSMGSYVKSTDLPQEKTALILKAFGQLKQQVIWKFENDSIGDLPSNVMIKK 350
            :.::: :..:|::.||:||.|  :::|::|...|..|.|::.|.|:|::......:|.:|.::.|
Human   292 EAYINASGEHGIVVFSLGSMV--SEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVK 354

  Fly   351 WMPQNDILAHPNVKLFITHGGIFGTQEGIYWGVPMLCVPLYGDQHRNTIKSVREGYARSLVFSKL 415
            |:||||:|.||..:.||||.|..|..|.|..||||:.:||:|||..|..:...:|...:|...::
Human   355 WLPQNDLLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEM 419

  Fly   416 TTDDLVRNIETLINDPQYKRSALEVSQRFRDNPIHPLDEATFWIEYIIRHRGARHLKSHGAFIPL 480
            |::||...::.:|||..||.:.:.:|...:|.|:.|||.|.||:|:::||:||.||:.....:..
Human   420 TSEDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTW 484

  Fly   481 HQYLLLDVLGCLLLGAFLAIWLPWR--------------MIRRVHK 512
            :||..|||:|.||.......::.::              .:::.||
Human   485 YQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHK 530

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt301D1	NP_609882.1	Glycosyltransferase_GTB-type	37..483	CDD:471961	134/485 (28%)
UGT1A3	NP_061966.1	UDPGT	29..525	CDD:278624	144/535 (27%)