Protein Alignment Ugt301D1 and UGT1A4

DIOPT Version :9

• Sequence 1: NP_001246079.1
• Gene: Ugt301D1 / 35105
• FlyBaseID: FBgn0032684
• Length: 530
• Species: Drosophila melanogaster
• Sequence 2: NP_009051.1
• Gene: UGT1A4 / 54657
• HGNCID: 12536
• Length: 534
• Species: Homo sapiens
• Alignment Length: 558
• Identity: 141/558 - (25%)
• Similarity: 255/558 - (45%)
• Gaps: 100/558 - (17%)

  Fly    12 LIFLIGLLEFGAGSRILFMGPFPAPSHWLWLEHFQNDLLRQGHHVTSVNNHPTKHPHENLTEIII 76
            |:.|:.:..:....::|.:....:|  ||.:.....:|..:||..                 :::
Human    16 LLLLLSVQPWAESGKVLVVPTDGSP--WLSMREALRELHARGHQA-----------------VVL 61

  Fly    77 SPSFDIPKHFPKENIFSMQFVS------DFNNLELWWTIGLMTTEHAFK---------------- 119
            :|  ::..|..:|..|::...:      :|:.:.|.:|.|...|||..|
Human    62 TP--EVNMHIKEEKFFTLTAYAVPWTQKEFDRVTLGYTQGFFETEHLLKRYSRSMAIMNNVSLAL 124

  Fly   120 ----------DPKVKKLIESKDDHYDLV----------IIEQFFHEAFLMFGKRFNCPVVTIGTM 164
                      :..::.|..:.   :|:|          ::.::.....:.|.:...|.:...||.
Human   125 HRCCVELLHNEALIRHLNATS---FDVVLTDPVNLCGAVLAKYLSIPAVFFWRYIPCDLDFKGTQ 186

  Fly   165 GYADNIDHAMGILTPWSLIPHLLLSHTDRMTFGQRAYNAYLSLYDAVMRRWVYLPKMQKLAEKYF 229
                       ...|.|.||.||.:::|.|||.||..|....|..:.:......| ...||.:.|
Human   187 -----------CPNPSSYIPKLLTTNSDHMTFLQRVKNMLYPLALSYICHTFSAP-YASLASELF 239

  Fly   230 QGSIEGPLPNVLDLERNISLVLINAHRSIDLPRPSMPGLIDVGGAHIQKPKQLPTDLQNFLD-NA 293
            |..:     :|:||....|:.|......:|.|||.||.::.:||.:....|.|..:.:.::: :.
Human   240 QREV-----SVVDLVSYASVWLFRGDFVMDYPRPIMPNMVFIGGINCANGKPLSQEFEAYINASG 299

  Fly   294 TYGVIYFSMGSYVKSTDLPQEKTALILKAFGQLKQQVIWKFENDSIGDLPSNVMIKKWMPQNDIL 358
            .:|::.||:||.|  :::|::|...|..|.|::.|.|:|::......:|.:|.::.||:||||:|
Human   300 EHGIVVFSLGSMV--SEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLL 362

  Fly   359 AHPNVKLFITHGGIFGTQEGIYWGVPMLCVPLYGDQHRNTIKSVREGYARSLVFSKLTTDDLVRN 423
            .||..:.||||.|..|..|.|..||||:.:||:|||..|..:...:|...:|...::|::||...
Human   363 GHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLENA 427

  Fly   424 IETLINDPQYKRSALEVSQRFRDNPIHPLDEATFWIEYIIRHRGARHLKSHGAFIPLHQYLLLDV 488
            ::.:|||..||.:.:.:|...:|.|:.|||.|.||:|:::||:||.||:.....:..:||..|||
Human   428 LKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQYHSLDV 492

  Fly   489 LGCLLLGAFLAIWLPWR--------------MIRRVHK 512
            :|.||.......::.::              .:::.||
Human   493 IGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHK 530

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt301D1	NP_001246079.1	egt	12..483	CDD:223071	131/513 (26%)
		UDPGT	37..483	CDD:278624	127/488 (26%)
UGT1A4	NP_009051.1	UDPGT	29..525	CDD:278624	137/538 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	260	1.000	Domainoid score	I1978
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	267	1.000	Inparanoid score	I3041
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm8543
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.760