DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt301D1 and UGT1A9

DIOPT Version :9

Sequence 1:	NP_001246079.1	Gene:	Ugt301D1 / 35105	FlyBaseID:	FBgn0032684	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_066307.1	Gene:	UGT1A9 / 54600	HGNCID:	12541	Length:	530	Species:	Homo sapiens

Alignment Length:	565	Identity:	153/565 - (27%)
Similarity:	264/565 - (46%)	Gaps:	112/565 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 CWMLIFLIGLLEFGAGSRILFMGPFPAPSHWLWLEHFQNDLLRQGHHVT---------------- 57
            |..|:...|..|.|.    |.:.|... |||..:......|:.:||.|.
Human    13 CVCLLLTCGFAEAGK----LLVVPMDG-SHWFTMRSVVEKLILRGHEVVVVMPEVSWQLGRSLNC 72

  Fly    58 SVNNHPTKHPHENLTEIIISPSFDIPKHFPK----------ENIFSMQFVSDFNNL-ELWWTIGL 111
            :|..:.|.:..|           |:.:.|..          .:|:|: .:..:|:: :|:::
Human    73 TVKTYSTSYTLE-----------DLDREFKAFAHAQWKAQVRSIYSL-LMGSYNDIFDLFFS--- 122

  Fly   112 MTTEHAFKDPKVKKLIE-SKDDHYDLVIIEQFFHEAFLMFGKRFNCPVVTIGTMGYADNIDHAMG 175
             .....|||   |||:| .|:..:|.|.::. |....|:..|.|:.|.|..           |.|
Human   123 -NCRSLFKD---KKLVEYLKESSFDAVFLDP-FDNCGLIVAKYFSLPSVVF-----------ARG 171

  Fly   176 IL-----------TPWSLIPHLLLSHTDRMTFGQRAYNAYLSLYDAVMRRWVYLPKMQKLAEKYF 229
            ||           .|.|.:|.:||..:|.|||.:|..|..:.|.:.:            |..::|
Human   172 ILCHYLEEGAQCPAPLSYVPRILLGFSDAMTFKERVRNHIMHLEEHL------------LCHRFF 224

  Fly   230 QGSIE-------GPLPNVLDLERNISLVLINAHRSIDLPRPSMPGLIDVGGAHIQKPKQLPTDLQ 287
            :.::|       .|:.. .||..:.|:.|:.....:|.|:|.||.:|.:||.:..:.|.||.:.:
Human   225 KNALEIASEILQTPVTE-YDLYSHTSIWLLRTDFVLDYPKPVMPNMIFIGGINCHQGKPLPMEFE 288

  Fly   288 NFLD-NATYGVIYFSMGSYVKSTDLPQEKTALILKAFGQLKQQVIWKFENDSIGDLPSNVMIKKW 351
            .::: :..:|::.||:||.|  :::|::|...|..|.|::.|.|:|::......:|.:|.::.||
Human   289 AYINASGEHGIVVFSLGSMV--SEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKW 351

  Fly   352 MPQNDILAHPNVKLFITHGGIFGTQEGIYWGVPMLCVPLYGDQHRNTIKSVREGYARSLVFSKLT 416
            :||||:|.||..:.||||.|..|..|.|..||||:.:||:|||..|..:...:|...:|...::|
Human   352 LPQNDLLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMT 416

  Fly   417 TDDLVRNIETLINDPQYKRSALEVSQRFRDNPIHPLDEATFWIEYIIRHRGARHLKSHGAFIPLH 481
            ::||...::.:|||..||.:.:.:|...:|.|:.|||.|.||:|:::||:||.||:.....:..:
Human   417 SEDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWY 481

  Fly   482 QYLLLDVLGCLLLGAFLAIWLPWR--------------MIRRVHK 512
            ||..|||:|.||.......::.::              .:::.||
Human   482 QYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHK 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt301D1	NP_001246079.1	egt	12..483	CDD:223071	142/517 (27%)
Ugt301D1	NP_001246079.1	UDPGT	37..483	CDD:278624	136/492 (28%)
UGT1A9	NP_066307.1	UDPGT	26..521	CDD:278624	147/545 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	260	1.000	Domainoid score	I1978
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	267	1.000	Inparanoid score	I3041
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm8543
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.760