Protein Alignment Ugt301D1 and UGT1A5

DIOPT Version :9

• Sequence 1: NP_001246079.1
• Gene: Ugt301D1 / 35105
• FlyBaseID: FBgn0032684
• Length: 530
• Species: Drosophila melanogaster
• Sequence 2: NP_061951.1
• Gene: UGT1A5 / 54579
• HGNCID: 12537
• Length: 534
• Species: Homo sapiens
• Alignment Length: 551
• Identity: 149/551 - (27%)
• Similarity: 256/551 - (46%)
• Gaps: 86/551 - (15%)

  Fly    12 LIFLIGLLEFGAGSRILFMGPFPAP-SHWLWLEHFQNDLLRQGHHVTSVNNHPTKHPHENLTEII 75
            |:.|:.:..:....::|.:   |.. ||||.:.....||..:||.|..:
Human    16 LLLLLSVQPWAESGKVLVV---PTDGSHWLSMREALRDLHARGHQVVVL---------------- 61

  Fly    76 ISPSFDIPKHFPKENIFSMQFVS------DFNNLELWWTIGLMTTEHAFKDPKVKKLI------- 127
               :.::..:..:||.|::...:      :|:.|.|..|.....|||.......:..|
Human    62 ---TLEVNMYIKEENFFTLTTYAISWTQDEFDRLLLGHTQSFFETEHLLMKFSRRMAIMNNMSLI 123

  Fly   128 -----------ESKDDH-----YDLVIIEQFFHEAFLMFGKRFNCPVVTIGTMGYADNIDHAMGI 176
                       |:...|     :|:|:.:. ||....:..|..:.|.|.     :..||...:..
Human   124 IHRSCVELLHNEALIRHLHATSFDVVLTDP-FHLCAAVLAKYLSIPAVF-----FLRNIPCDLDF 182

  Fly   177 L-----TPWSLIPHLLLSHTDRMTFGQRAYNAYLSLYDAVMRRWVYLPKMQKLAEKYFQGSIEGP 236
            .     .|.|.||.||.:::|.|||.||..|....|..:.:...|..| ...||.:.||..:
Human   183 KGTQCPNPSSYIPRLLTTNSDHMTFLQRVKNMLYPLALSYLCHAVSAP-YASLASELFQREV--- 243

  Fly   237 LPNVLDLERNISLVLINAHRSIDLPRPSMPGLIDVGGAHIQKPKQLPTDLQNFLD-NATYGVIYF 300
              :|:||..:.|:.|......:|.|||.||.::.:||.:....|.|..:.:.::: :..:|::.|
Human   244 --SVVDLVSHASVWLFRGDFVMDYPRPIMPNMVFIGGINCANGKPLSQEFEAYINASGEHGIVVF 306

  Fly   301 SMGSYVKSTDLPQEKTALILKAFGQLKQQVIWKFENDSIGDLPSNVMIKKWMPQNDILAHPNVKL 365
            |:||.|  :::|::|...|..|.|::.|.|:|::......:|.:|.::.||:||||:|.||..:.
Human   307 SLGSMV--SEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGHPMTRA 369

  Fly   366 FITHGGIFGTQEGIYWGVPMLCVPLYGDQHRNTIKSVREGYARSLVFSKLTTDDLVRNIETLIND 430
            ||||.|..|..|.|..||||:.:||:|||..|..:...:|...:|...::|::||...::.:|||
Human   370 FITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLENALKAVIND 434

  Fly   431 PQYKRSALEVSQRFRDNPIHPLDEATFWIEYIIRHRGARHLKSHGAFIPLHQYLLLDVLGCLLLG 495
            ..||.:.:.:|...:|.|:.|||.|.||:|:::||:||.||:.....:..:||..|||:|.||..
Human   435 KSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAV 499

  Fly   496 AFLAIWLPWR--------------MIRRVHK 512
            .....::.::              .:::.||
Human   500 VLTVAFITFKCCAYGYRKCLGKKGRVKKAHK 530

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt301D1	NP_001246079.1	egt	12..483	CDD:223071	139/506 (27%)
		UDPGT	37..483	CDD:278624	135/480 (28%)
UGT1A5	NP_061951.1	UDPGT	29..525	CDD:278624	145/531 (27%)
		egt	<262..508	CDD:223071	87/247 (35%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	260	1.000	Domainoid score	I1978
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	267	1.000	Inparanoid score	I3041
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm8543
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.860