Protein Alignment Ugt301D1 and UGT1A6

DIOPT Version :10

• Sequence 1: NP_609882.1
• Gene: Ugt301D1 / 35105
• FlyBaseID: FBgn0032684
• Length: 530
• Species: Drosophila melanogaster
• Sequence 2: NP_001063.2
• Gene: UGT1A6 / 54578
• HGNCID: 12538
• Length: 532
• Species: Homo sapiens
• Alignment Length: 547
• Identity: 143/547 - (26%)
• Similarity: 255/547 - (46%)
• Gaps: 80/547 - (14%)

  Fly    13 IFLIGLLEFGAGSRILFMGPFPAP-SHWLWLEHFQNDLLRQGHHVTSV----------------N 60
            :|.:.|.....|.::|.:   |.. ||||.::.....|..:||.:..|                .
Human    15 VFFLALWGMVVGDKLLVV---PQDGSHWLSMKDIVEVLSDRGHEIVVVVPEVNLLLKESKYYTRK 76

  Fly    61 NHPTKHPHENLTEIIISPSFDIPKHFPKENIFSMQFVSDFNNLELWWTIGLMTTEHAFKDPKVKK 125
            .:|..:..|.|....  .||. ..||.:.:..:.......||:.:   |||...       ..:.
Human    77 IYPVPYDQEELKNRY--QSFG-NNHFAERSFLTAPQTEYRNNMIV---IGLYFI-------NCQS 128

  Fly   126 LIESKDDHYDLVIIEQFFHEAFLMFGKRFNCPVVTIGTM--------------GYADNIDHAMG- 175
            |::.:|       ...||.|:  .|...|..|.:..|.:              |:..:::|...
Human   129 LLQDRD-------TLNFFKES--KFDALFTDPALPCGVILAEYLGLPSVYLFRGFPCSLEHTFSR 184

  Fly   176 ILTPWSLIPHLLLSHTDRMTFGQRAYNAYLSLYDAVMRRWVYLPKMQKLAEKYFQGSIEGPLPNV 240
            ...|.|.||......:|.|||.||..|..::|.:..: .:....|.::||....:..::     :
Human   185 SPDPVSYIPRCYTKFSDHMTFSQRVANFLVNLLEPYL-FYCLFSKYEELASAVLKRDVD-----I 243

  Fly   241 LDLERNISLVLINAHRSIDLPRPSMPGLIDVGGAHIQKPKQLPTDLQNFLD-NATYGVIYFSMGS 304
            :.|.:.:|:.|:.....::.|||.||.::.:||.:.:|.|.|..:.:.::: :..:|::.||:||
Human   244 ITLYQKVSVWLLRYDFVLEYPRPVMPNMVFIGGINCKKRKDLSQEFEAYINASGEHGIVVFSLGS 308

  Fly   305 YVKSTDLPQEKTALILKAFGQLKQQVIWKFENDSIGDLPSNVMIKKWMPQNDILAHPNVKLFITH 369
            .|  :::|::|...|..|.|::.|.|:|::......:|.:|.::.||:||||:|.||..:.||||
Human   309 MV--SEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGHPMTRAFITH 371

  Fly   370 GGIFGTQEGIYWGVPMLCVPLYGDQHRNTIKSVREGYARSLVFSKLTTDDLVRNIETLINDPQYK 434
            .|..|..|.|..||||:.:||:|||..|..:...:|...:|...::|::||...::.:|||..||
Human   372 AGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLENALKAVINDKSYK 436

  Fly   435 RSALEVSQRFRDNPIHPLDEATFWIEYIIRHRGARHLKSHGAFIPLHQYLLLDVLGCLLLGAFLA 499
            .:.:.:|...:|.|:.|||.|.||:|:::||:||.||:.....:..:||..|||:|.||......
Human   437 ENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAVVLTV 501

  Fly   500 IWLPWR--------------MIRRVHK 512
            .::.::              .:::.||
Human   502 AFITFKCCAYGYRKCLGKKGRVKKAHK 528

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt301D1	NP_609882.1	Glycosyltransferase_GTB-type	37..483	CDD:471961	128/477 (27%)
UGT1A6	NP_001063.2	UDPGT	27..523	CDD:278624	138/528 (26%)