Protein Alignment Ugt301D1 and UGT1A6

DIOPT Version :9

• Sequence 1: NP_001246079.1
• Gene: Ugt301D1 / 35105
• FlyBaseID: FBgn0032684
• Length: 530
• Species: Drosophila melanogaster
• Sequence 2: NP_001063.2
• Gene: UGT1A6 / 54578
• HGNCID: 12538
• Length: 532
• Species: Homo sapiens
• Alignment Length: 547
• Identity: 143/547 - (26%)
• Similarity: 255/547 - (46%)
• Gaps: 80/547 - (14%)

  Fly    13 IFLIGLLEFGAGSRILFMGPFPAP-SHWLWLEHFQNDLLRQGHHVTSV----------------N 60
            :|.:.|.....|.::|.:   |.. ||||.::.....|..:||.:..|                .
Human    15 VFFLALWGMVVGDKLLVV---PQDGSHWLSMKDIVEVLSDRGHEIVVVVPEVNLLLKESKYYTRK 76

  Fly    61 NHPTKHPHENLTEIIISPSFDIPKHFPKENIFSMQFVSDFNNLELWWTIGLMTTEHAFKDPKVKK 125
            .:|..:..|.|....  .||. ..||.:.:..:.......||:.:   |||...       ..:.
Human    77 IYPVPYDQEELKNRY--QSFG-NNHFAERSFLTAPQTEYRNNMIV---IGLYFI-------NCQS 128

  Fly   126 LIESKDDHYDLVIIEQFFHEAFLMFGKRFNCPVVTIGTM--------------GYADNIDHAMG- 175
            |::.:|       ...||.|:  .|...|..|.:..|.:              |:..:::|...
Human   129 LLQDRD-------TLNFFKES--KFDALFTDPALPCGVILAEYLGLPSVYLFRGFPCSLEHTFSR 184

  Fly   176 ILTPWSLIPHLLLSHTDRMTFGQRAYNAYLSLYDAVMRRWVYLPKMQKLAEKYFQGSIEGPLPNV 240
            ...|.|.||......:|.|||.||..|..::|.:..: .:....|.::||....:..::     :
Human   185 SPDPVSYIPRCYTKFSDHMTFSQRVANFLVNLLEPYL-FYCLFSKYEELASAVLKRDVD-----I 243

  Fly   241 LDLERNISLVLINAHRSIDLPRPSMPGLIDVGGAHIQKPKQLPTDLQNFLD-NATYGVIYFSMGS 304
            :.|.:.:|:.|:.....::.|||.||.::.:||.:.:|.|.|..:.:.::: :..:|::.||:||
Human   244 ITLYQKVSVWLLRYDFVLEYPRPVMPNMVFIGGINCKKRKDLSQEFEAYINASGEHGIVVFSLGS 308

  Fly   305 YVKSTDLPQEKTALILKAFGQLKQQVIWKFENDSIGDLPSNVMIKKWMPQNDILAHPNVKLFITH 369
            .|  :::|::|...|..|.|::.|.|:|::......:|.:|.::.||:||||:|.||..:.||||
Human   309 MV--SEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGHPMTRAFITH 371

  Fly   370 GGIFGTQEGIYWGVPMLCVPLYGDQHRNTIKSVREGYARSLVFSKLTTDDLVRNIETLINDPQYK 434
            .|..|..|.|..||||:.:||:|||..|..:...:|...:|...::|::||...::.:|||..||
Human   372 AGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLENALKAVINDKSYK 436

  Fly   435 RSALEVSQRFRDNPIHPLDEATFWIEYIIRHRGARHLKSHGAFIPLHQYLLLDVLGCLLLGAFLA 499
            .:.:.:|...:|.|:.|||.|.||:|:::||:||.||:.....:..:||..|||:|.||......
Human   437 ENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAVVLTV 501

  Fly   500 IWLPWR--------------MIRRVHK 512
            .::.::              .:::.||
Human   502 AFITFKCCAYGYRKCLGKKGRVKKAHK 528

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt301D1	NP_001246079.1	egt	12..483	CDD:223071	133/502 (26%)
		UDPGT	37..483	CDD:278624	128/477 (27%)
UGT1A6	NP_001063.2	egt	15..506	CDD:223071	141/523 (27%)
		UDPGT	27..523	CDD:278624	138/528 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	260	1.000	Domainoid score	I1978
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	267	1.000	Inparanoid score	I3041
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm8543
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.760