Protein Alignment Ugt301D1 and UGT1A8

DIOPT Version :10

• Sequence 1: NP_609882.1
• Gene: Ugt301D1 / 35105
• FlyBaseID: FBgn0032684
• Length: 530
• Species: Drosophila melanogaster
• Sequence 2: NP_061949.3
• Gene: UGT1A8 / 54576
• HGNCID: 12540
• Length: 530
• Species: Homo sapiens
• Alignment Length: 536
• Identity: 146/536 - (27%)
• Similarity: 259/536 - (48%)
• Gaps: 54/536 - (10%)

  Fly     9 CWMLIFLIGLLEFGAGSRILFMGPFPAPSHWLWLEHFQNDLLRQGHHVT---------------- 57
            |..|:...|..|.|.    |.:.|... |||..::.....|:.:||.|.
Human    13 CVSLLLTCGFAEAGK----LLVVPMDG-SHWFTMQSVVEKLILRGHEVVVVMPEVSWQLGKSLNC 72

  Fly    58 SVNNHPTKHPHENLTEIIISPSFDIPKHFPKENIFSMQFVSDFNNLELWWTIGLMTTEHAFKDPK 122
            :|..:.|.:..|:|....:..: |........::||: |:|..|.   ::.:........|.|
Human    73 TVKTYSTSYTLEDLDREFMDFA-DAQWKAQVRSLFSL-FLSSSNG---FFNLFFSHCRSLFND-- 130

  Fly   123 VKKLIE-SKDDHYDLVIIEQFFHEAFLMFGKRFNCPVVTIGTMGYADNIDHAMGILTPWSLIPHL 186
             :||:| .|:..:|.|.::. |....|:..|.|:.|.|..........::.......|.|.:|.:
Human   131 -RKLVEYLKESSFDAVFLDP-FDACGLIVAKYFSLPSVVFARGIACHYLEEGAQCPAPLSYVPRI 193

  Fly   187 LLSHTDRMTFGQRAYNAYLSLYDAVMRRWVYLPKMQKLAEKYFQGSIEGPLPNVLDLERNISLVL 251
            ||..:|.|||.:|..|..:.|.:.:..:: :.....::|.:..|..:     ...||..:.|:.|
Human   194 LLGFSDAMTFKERVRNHIMHLEEHLFCQY-FSKNALEIASEILQTPV-----TAYDLYSHTSIWL 252

  Fly   252 INAHRSIDLPRPSMPGLIDVGGAHIQKPKQLPTDLQNFLD-NATYGVIYFSMGSYVKSTDLPQEK 315
            :.....:|.|:|.||.:|.:||.:..:.|.||.:.:.::: :..:|::.||:||.|  :::|::|
Human   253 LRTDFVLDYPKPVMPNMIFIGGINCHQGKPLPMEFEAYINASGEHGIVVFSLGSMV--SEIPEKK 315

  Fly   316 TALILKAFGQLKQQVIWKFENDSIGDLPSNVMIKKWMPQNDILAHPNVKLFITHGGIFGTQEGIY 380
            ...|..|.|::.|.|:|::......:|.:|.::.||:||||:|.||..:.||||.|..|..|.|.
Human   316 AMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGHPMTRAFITHAGSHGVYESIC 380

  Fly   381 WGVPMLCVPLYGDQHRNTIKSVREGYARSLVFSKLTTDDLVRNIETLINDPQYKRSALEVSQRFR 445
            .||||:.:||:|||..|..:...:|...:|...::|::||...::.:|||..||.:.:.:|...:
Human   381 NGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLENALKAVINDKSYKENIMRLSSLHK 445

  Fly   446 DNPIHPLDEATFWIEYIIRHRGARHLKSHGAFIPLHQYLLLDVLGCLLLGAFLAIWLPWR----- 505
            |.|:.|||.|.||:|:::||:||.||:.....:..:||..|||:|.||.......::.::
Human   446 DRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAVVLTVAFITFKCCAYG 510

  Fly   506 ---------MIRRVHK 512
                     .:::.||
Human   511 YRKCLGKKGRVKKAHK 526

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt301D1	NP_609882.1	Glycosyltransferase_GTB-type	37..483	CDD:471961	129/463 (28%)
UGT1A8	NP_061949.3	UDPGT	26..521	CDD:278624	140/516 (27%)