DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt301D1 and UGT1A10

DIOPT Version :9

Sequence 1:	NP_001246079.1	Gene:	Ugt301D1 / 35105	FlyBaseID:	FBgn0032684	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_061948.1	Gene:	UGT1A10 / 54575	HGNCID:	12531	Length:	530	Species:	Homo sapiens

Alignment Length:	543	Identity:	149/543 - (27%)
Similarity:	265/543 - (48%)	Gaps:	68/543 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 CWMLIFLIGLLEFGAGSRILFMGPFPAPSHWLWLEHFQNDLLRQGHHVT---------------- 57
            |..|:...|..|.|.    |.:.|... |||..::.....|:.:||.|.
Human    13 CVCLLLTCGFAEAGK----LLVVPMDG-SHWFTMQSVVEKLILRGHEVVVVMPEVSWQLERSLNC 72

  Fly    58 SVNNHPTKHPHENLTEIIISPSFDIPKH----FPKENIFSMQFVSDFNNLELWWTIGLMTTEHA- 117
            :|..:.|.:..|:...     .|.:..|    ...::|||:...|....|:|:::       |.
Human    73 TVKTYSTSYTLEDQNR-----EFMVFAHAQWKAQAQSIFSLLMSSSSGFLDLFFS-------HCR 125

  Fly   118 --FKDPKVKKLIE-SKDDHYDLVIIEQFFHEAFLMFGKRFNCPVVTIGTMGYADNIDHAMGILTP 179
              |.|   :||:| .|:..:|.|.::. |....|:..|.|:.|.|......:..:::.......|
Human   126 SLFND---RKLVEYLKESSFDAVFLDP-FDTCGLIVAKYFSLPSVVFTRGIFCHHLEEGAQCPAP 186

  Fly   180 WSLIPHLLLSHTDRMTFGQRAYNAYLSLYDAVMRRWVYLPKMQKLAEKYFQGSIEGPLPNVLDLE 244
            .|.:|:.||..:|.|||.:|.:|..:.|.|.:..::::...:: :|.:..|..:     ...||.
Human   187 LSYVPNDLLGFSDAMTFKERVWNHIVHLEDHLFCQYLFRNALE-IASEILQTPV-----TAYDLY 245

  Fly   245 RNISLVLINAHRSIDLPRPSMPGLIDVGGAHIQKPKQLPTDLQNFLD-NATYGVIYFSMGSYVKS 308
            .:.|:.|:.....:|.|:|.||.:|.:||.:..:.|.||.:.:.::: :..:|::.||:||.|
Human   246 SHTSIWLLRTDFVLDYPKPVMPNMIFIGGINCHQGKPLPMEFEAYINASGEHGIVVFSLGSMV-- 308

  Fly   309 TDLPQEKTALILKAFGQLKQQVIWKFENDSIGDLPSNVMIKKWMPQNDILAHPNVKLFITHGGIF 373
            :::|::|...|..|.|::.|.|:|::......:|.:|.::.||:||||:|.||..:.||||.|..
Human   309 SEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGHPMTRAFITHAGSH 373

  Fly   374 GTQEGIYWGVPMLCVPLYGDQHRNTIKSVREGYARSLVFSKLTTDDLVRNIETLINDPQYKRSAL 438
            |..|.|..||||:.:||:|||..|..:...:|...:|...::|::||...::.:|||..||.:.:
Human   374 GVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLENALKAVINDKSYKENIM 438

  Fly   439 EVSQRFRDNPIHPLDEATFWIEYIIRHRGARHLKSHGAFIPLHQYLLLDVLGCLLLGAFLAIWLP 503
            .:|...:|.|:.|||.|.||:|:::||:||.||:.....:..:||..|||:|.||.......::.
Human   439 RLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAVVLTVAFIT 503

  Fly   504 WR--------------MIRRVHK 512
            ::              .:::.||
Human   504 FKCCAYGYRKCLGKKGRVKKAHK 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt301D1	NP_001246079.1	egt	12..483	CDD:223071	138/495 (28%)
Ugt301D1	NP_001246079.1	UDPGT	37..483	CDD:278624	132/470 (28%)
UGT1A10	NP_061948.1	UDPGT	26..521	CDD:278624	143/523 (27%)
UGT1A10	NP_061948.1	egt	<258..504	CDD:223071	88/247 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	260	1.000	Domainoid score	I1978
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	267	1.000	Inparanoid score	I3041
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm8543
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.760