Protein Alignment Ugt301D1 and UGT2B28

DIOPT Version :9

• Sequence 1: NP_001246079.1
• Gene: Ugt301D1 / 35105
• FlyBaseID: FBgn0032684
• Length: 530
• Species: Drosophila melanogaster
• Sequence 2: NP_444267.1
• Gene: UGT2B28 / 54490
• HGNCID: 13479
• Length: 529
• Species: Homo sapiens
• Alignment Length: 552
• Identity: 161/552 - (29%)
• Similarity: 266/552 - (48%)
• Gaps: 69/552 - (12%)

  Fly     3 MQLQWKCWMLIFLIGLLEFGAGS---RILFMGPFPAPSHWLWLEHFQNDLLRQGHHVT------- 57
            |.|:|...:|:..:|.. |.:||   .:::.|.:   |||:.::....:|:::||.||
Human     1 MALKWTSVLLLIHLGCY-FSSGSCGKVLVWTGEY---SHWMNMKTILKELVQRGHEVTVLASSAS 61

  Fly    58 -----------SVNNHP---TKHPHENLTEIIISPSFDIPK-----HFPKENIFSMQFVSDFNNL 103
                       .:..:|   ||...||:....:....||.|     :|.:|.....:|...|.|.
Human    62 ILFDPNDAFTLKLEVYPTSLTKTEFENIIMQQVKRWSDIQKDSFWLYFSQEQEILWEFHDIFRNF 126

  Fly   104 ELWWTIGLMTTEHAFKDPKV-KKLIESKDDHYDLVIIEQFFHEAFLMFGKRFNCPVV--TIGTMG 165
                      .:....:.|| |||.||:   :|::..:.||....|: ....|.|.|  ...|.|
Human   127 ----------CKDVVSNKKVMKKLQESR---FDIIFADAFFPCGELL-AALLNIPFVYSLCFTPG 177

  Fly   166 YADNID-HAMGILTPWSLIPHLLLSHTDRMTFGQRAYNAYLSLYDAVMRRWVYLPKMQKLAEKYF 229
            |  .|: |:.|::.|.|.||.::...:|:|||.:|..|....||   ...|..:..|:|..:  |
Human   178 Y--TIERHSGGLIFPPSYIPVVMSKLSDQMTFMERVKNMIYVLY---FDFWFQMCDMKKWDQ--F 235

  Fly   230 QGSIEGPLPNVLDLERNISLVLINAHRSIDLPRPSMPGLIDVGGAHIQKPKQLPTDLQNFLDNA- 293
            ...:.|....:.:......:.|:....|...|.|.:|.:..|||.|.:..|.||.:::.|:.::
Human   236 YSEVLGRPTTLFETMGKADIWLMRNSWSFQFPHPFLPNIDFVGGLHCKPAKPLPKEMEEFVQSSG 300

  Fly   294 TYGVIYFSMGSYVKSTDLPQEKTALILKAFGQLKQQVIWKFENDSIGDLPSNVMIKKWMPQNDIL 358
            ..||:.||:||.:  :::..|:..:|..|..::.|:|:|:|:.:....|..|..:.||:||||:|
Human   301 ENGVVVFSLGSVI--SNMTAERANVIATALAKIPQKVLWRFDGNKPDALGLNTRLYKWIPQNDLL 363

  Fly   359 AHPNVKLFITHGGIFGTQEGIYWGVPMLCVPLYGDQHRNTIKSVREGYARSLVFSKLTTDDLVRN 423
            ..|..:.||||||..|..|.||.|:||:.:||:.||..|......:|.|..|.|..:::.||:..
Human   364 GLPKTRAFITHGGANGIYEAIYHGIPMVGIPLFWDQPDNIAHMKAKGAAVRLDFHTMSSTDLLNA 428

  Fly   424 IETLINDPQYKRSALEVSQRFRDNPIHPLDEATFWIEYIIRHRGARHLKSHGAFIPLHQYLLLDV 488
            ::|:||||.||.:.:::|....|.|:.||..|.||||:::.|:||:||:.....:...||..|||
Human   429 LKTVINDPSYKENVMKLSIIQHDQPVKPLHRAVFWIEFVMCHKGAKHLRVAARDLTWFQYHSLDV 493

  Fly   489 LGCLLLGAFLAIWLP--------WRMIRRVHK 512
            :|.||......|::.        |:..|:..|
Human   494 IGFLLACVATVIFVVTKFCLFCFWKFARKGKK 525

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt301D1	NP_001246079.1	egt	12..483	CDD:223071	146/504 (29%)
		UDPGT	37..483	CDD:278624	140/476 (29%)
UGT2B28	NP_444267.1	UDPGT	24..525	CDD:278624	152/526 (29%)
		egt	<269..506	CDD:223071	87/238 (37%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	260	1.000	Domainoid score	I1978
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	267	1.000	Inparanoid score	I3041
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm8543
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.760