DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt301D1 and Ugt8

DIOPT Version :9

Sequence 1:	NP_001246079.1	Gene:	Ugt301D1 / 35105	FlyBaseID:	FBgn0032684	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_062149.1	Gene:	Ugt8 / 50555	RGDID:	3938	Length:	541	Species:	Rattus norvegicus

Alignment Length:	542	Identity:	153/542 - (28%)
Similarity:	266/542 - (49%)	Gaps:	87/542 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 WMLIF-LIGLLEFGAGSRILFMGPFPAPSHWLWLEHFQNDLLRQGHHVTSVNNHPTKHPHENLTE 73
            :||:: .:|:   ...::|:.:.|....||....:...:.|..:|||                |.
  Rat     8 FMLLWSAVGI---ARAAKIIIVPPIMFESHLYIFKTLASALHERGHH----------------TV 53

  Fly    74 IIISPSFDIPKHFPKENIFSMQ-FVSDFNNLELWWTIGLMTTEHAFKDPKVKKLIESKDDHYDLV 137
            .::|...||    ...|.:|:| :...||:          ||..||...|::.:...:....:||
  Rat    54 FLLSEGRDI----DPSNHYSLQRYPGIFNS----------TTSDAFLQSKMRNIFSGRLTAVELV 104

  Fly   138 -IIEQFFHEAFLMFG----------KRFNCPVVTIGTM-GYADNIDHAMGIL------------- 177
             |::.:.....:|.|          ::|:..:|....| |:.  |.|.:|:.
  Rat   105 DILDHYTKNCDMMVGNQALIQGLKKEKFDLLLVDPNDMCGFV--IAHLLGVKYAVFSTGLWYPAE 167

  Fly   178 ----TPWSLIPHLLLSHTDRMTFGQRAYNAYLSLYDAVMRRWVYLPKMQKLAEKYFQGSIEGPLP 238
                .|.:.:|......||||.|.:|..|..:.|...:...::.|||.:::.:||      ..||
  Rat   168 VGAPAPLAYVPEFNSLLTDRMNFLERMKNTGVYLISRMGVSFLVLPKYERIMQKY------NLLP 226

  Fly   239 --NVLDLERNISLVLINAHRSIDLPRPSMPGLIDVGGAHIQKPKQLPTDLQNFLDNA-TYGVIYF 300
              ::.||....||.::....:::.|||::|.::.|||...:....||.|||.::|.| .:|.:..
  Rat   227 AKSMYDLVHGSSLWMLCTDVALEFPRPTLPNVVYVGGILTKPASPLPEDLQRWVDGAQEHGFVLV 291

  Fly   301 SMGSYVK--STDLPQEKTALILKAFGQLKQQVIWKFENDSIGDLPSNVMIKKWMPQNDILAHPNV 363
            |.|:.||  |.|:..:    :..|.|:|.|:|||:|......:|.:|..:.:|:||||:|.|.|:
  Rat   292 SFGAGVKYLSEDIANK----LAGALGRLPQKVIWRFSGTKPKNLGNNTKLIEWLPQNDLLGHSNI 352

  Fly   364 KLFITHGGIFGTQEGIYWGVPMLCVPLYGDQHRNTIKSVR-EGYARSLVFSKLTTDDLVRNIETL 427
            :.|::|||:....|.:|.|||::.:||:|| |.:|:..|: :|....|.::.:|..:|...:..:
  Rat   353 RAFLSHGGLNSIFETMYHGVPVVGIPLFGD-HYDTMTRVQAKGMGILLEWNTVTEGELYDALVKV 416

  Fly   428 INDPQYKRSALEVSQRFRDNPIHPLDEATFWIEYIIRHRGARHLKSHGAFIPLHQYLLLDVLGCL 492
            ||:|.|::.|.::|:..:|.|.||::..|:||:||:||.||.||:|....|...||.|||:...|
  Rat   417 INNPSYRQRAQKLSEIHKDQPGHPVNRTTYWIDYILRHDGAHHLRSAVHQISFCQYFLLDIAFVL 481

  Fly   493 LLGA----FLAIWLPWRMIRRV 510
            ||||    |:..::...:.|:|
  Rat   482 LLGAVALYFIVSYVTKFIYRKV 503

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt301D1	NP_001246079.1	egt	12..483	CDD:223071	139/507 (27%)
Ugt301D1	NP_001246079.1	UDPGT	37..483	CDD:278624	135/481 (28%)
Ugt8	NP_062149.1	egt	8..490	CDD:223071	150/527 (28%)
Ugt8	NP_062149.1	UDPGT	21..502	CDD:278624	148/523 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	256	1.000	Domainoid score	I1959
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm9018
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.810