DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt301D1 and RGD1559459

DIOPT Version :9

Sequence 1:	NP_001246079.1	Gene:	Ugt301D1 / 35105	FlyBaseID:	FBgn0032684	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	XP_003751392.1	Gene:	RGD1559459 / 501907	RGDID:	1559459	Length:	530	Species:	Rattus norvegicus

Alignment Length:	527	Identity:	150/527 - (28%)
Similarity:	253/527 - (48%)	Gaps:	81/527 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 MLIFLIGLLEFGAGSRILFMGPFPAP-SHWLWLEHFQNDLLRQGHHVTSVNNHPTKHPHENLTEI 74
            :|:.|......|:|.::|.   :|.. ||||.|:...::|:::||.|                 :
  Rat    10 LLLHLTIFFGSGSGGKVLV---WPVEFSHWLNLKIILSELVKKGHEV-----------------V 54

  Fly    75 IISPSFDIPKHFPKENIFSMQ-FVSDFNNLELWWTIGLMTTEHAFKDPK---------VKKLIES 129
            ::.||........|.:....: |.|.::..::.........|..::.||         ::||.|.
  Rat    55 VLKPSVSFSYEVDKTSAIEFESFPSSYSIADVEVIFMDCVNESIYELPKQSFWGYFLMLQKLFER 119

  Fly   130 KDDH----------------------YDLVIIEQF---------FHEAFLMFGKRFNCPVVTIGT 163
            ..|:                      :|:::.:.|         ..:..|::..|| .|..|..
  Rat   120 TSDYSERLCRDAAFNKELMTKLQNSGFDVILADPFTPCGDLLAEILKIPLVYSLRF-FPGSTYE- 182

  Fly   164 MGYADNIDHAMGILTPWSLIPHLLLSHTDRMTFGQRA-YNAYLSLYDAVMRRWVYLPKMQKLAEK 227
                   .::.|:..|.|.:|..:...:|||||.:|. :..|:..:|.    |..:...:|..|.
  Rat   183 -------KYSGGLPMPPSYVPIAMSELSDRMTFVERVKHMIYVLCFDF----WFQVFDEKKWNEL 236

  Fly   228 YFQGSIEGPLPNVLDLERNISLVLINAHRSIDLPRPSMPGLIDVGGAHIQKPKQLPTDLQNFLDN 292
            |.:  :.|....:.:......:.||..:..::.|.|.:|....|||.|.:..|.||.::::|:.:
  Rat   237 YTE--VLGRPTTLSETMAKADIWLIRTYWDLEFPHPVLPNFDFVGGLHCRPAKPLPKEIEDFVQS 299

  Fly   293 A-TYGVIYFSMGSYVKSTDLPQEKTALILKAFGQLKQQVIWKFENDSIGDLPSNVMIKKWMPQND 356
            : .:||:.||:||.|.|  |.:|:..:|.....|:.|:|:|:||......|.||..:.||:||||
  Rat   300 SGEHGVVVFSLGSMVGS--LTEERANVIAAGLAQIPQKVLWRFEGKKPETLGSNTRLYKWIPQND 362

  Fly   357 ILAHPNVKLFITHGGIFGTQEGIYWGVPMLCVPLYGDQHRNTIKSVREGYARSLVFSKLTTDDLV 421
            :|.||..:.||||||..|..|.||.|:|::.:||:|||..|.:....:|.|..|.|..:::.||:
  Rat   363 LLGHPKTRAFITHGGTNGIYEAIYHGIPVVGIPLFGDQKDNIVHLKTKGAAVRLDFLTMSSTDLL 427

  Fly   422 RNIETLINDPQYKRSALEVSQRFRDNPIHPLDEATFWIEYIIRHRGARHLKSHGAFIPLHQYLLL 486
            ..:.|:.|||.||.:|:.:|:...|.|:.|||.|.||||:::||:||:||:..|..:...||..|
  Rat   428 TALRTVTNDPSYKENAMRLSRIHHDQPVKPLDRAVFWIEFVMRHKGAKHLRVAGHDLSWVQYHSL 492

  Fly   487 DVLGCLL 493
            ||:|.||
  Rat   493 DVIGFLL 499

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt301D1	NP_001246079.1	egt	12..483	CDD:223071	142/514 (28%)
Ugt301D1	NP_001246079.1	UDPGT	37..483	CDD:278624	136/488 (28%)
RGD1559459	XP_003751392.1	UDPGT	24..527	CDD:278624	146/513 (28%)
RGD1559459	XP_003751392.1	egt	<270..508	CDD:223071	96/232 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	256	1.000	Domainoid score	I1959
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	275	1.000	Inparanoid score	I2882
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm9018
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.760