DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt301D1 and Ugt35D1

DIOPT Version :9

Sequence 1:	NP_001246079.1	Gene:	Ugt301D1 / 35105	FlyBaseID:	FBgn0032684	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_651866.1	Gene:	Ugt35D1 / 43708	FlyBaseID:	FBgn0051002	Length:	521	Species:	Drosophila melanogaster

Alignment Length:	503	Identity:	160/503 - (31%)
Similarity:	269/503 - (53%)	Gaps:	30/503 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 IFLIGLL--EFGAGSRILFMGPFPAPSHWLWLEHFQNDLLRQGHHVTSVNNHPTKHPHENLTEII 75
            |||:..|  .:..|:|||.:.|.|:.||:.:...:...|...||.:|||:.:|.:.|..|:.:|.
  Fly     4 IFLLVCLLPGYSEGARILAVFPLPSSSHYFFALPYLKSLASLGHEITSVSPYPQREPFRNIHDIP 68

  Fly    76 ISPSFDIPKHF---------PKENIFSMQFVSDFNNLELWWTIGLMTTEHAFKDPKVKKLIESKD 131
            :...|:   :|         |:....|..|:::: .|.|..|:  :..|...:|     ::..:.
  Fly    69 VPEVFE---NFNEVLRIASTPRSTWQSSDFINEY-VLNLTKTV--LNNEGVRRD-----ILGPQK 122

  Fly   132 DHYDLVIIEQFFHEAFLMFGKRFNCPVVTIGTMGYADNIDHAMGILTPWSLIPHLLLSHTDRMTF 196
            .|:||||::.:..:........|:.|::.:.:.|....||..||.::|.|.:........|...:
  Fly   123 PHFDLVIMDLWRMDVLSGLAAYFDAPIIGMASYGTDWKIDELMGNVSPISYLQSPSSRFYDLEAY 187

  Fly   197 GQRAYNAYLSLYDAVMRRWVYLPKMQKLAEKYFQGSIE-GPLPNVLDLERNISLVLINAHRSIDL 260
            |:|..:.....:..:..:|.::.|.:.|..::|....| .||.   ::.||..|||:|.|.::..
  Fly   188 GERLLHLMERTFSYMNYKWRHVRKQETLYSQFFPSVAERKPLS---EISRNFDLVLVNQHFTLGP 249

  Fly   261 PRPSMPGLIDVGGAHI-QKPKQLPTDLQNFLDNA-TYGVIYFSMGSYVKSTDLPQEKTALILKAF 323
            |||.:|.:|.|||.|: ...:.|..:|.:|:..| ..||||||:|:.|||..|.:::..::|:.|
  Fly   250 PRPYVPNMIQVGGLHVDHSTEALSAELDHFIQGAGESGVIYFSLGTNVKSKSLSEDRRKVLLETF 314

  Fly   324 GQLKQQVIWKFENDSIGDLPSNVMIKKWMPQNDILAHPNVKLFITHGGIFGTQEGIYWGVPMLCV 388
            ..|.|:::||||::.:...|.||.|.||.||..|||||||||||||||:..|.|.|:.|.|||.:
  Fly   315 ASLPQRIVWKFEDELLPGKPPNVFISKWFPQQAILAHPNVKLFITHGGLLSTIESIHHGKPMLGL 379

  Fly   389 PLYGDQHRNTIKSVRE-GYARSLVFSKLTTDDLVRNIETLINDPQYKRSALEVSQRFRDNPIHPL 452
            |...||.|| :..||: |....|...::|:::....|..|:.:..::.:|...:.|:||.|:.|:
  Fly   380 PCLFDQFRN-MDHVRQVGLGLVLNIKQMTSEEFRSTIIRLLTNKSFEETARITAARYRDQPMKPM 443

  Fly   453 DEATFWIEYIIRHRGARHLKSHGAFIPLHQYLLLDVLGCLLLGAFLAI 500
            :.|.:|.||::.|:||.|::..|..:...:|..|||.|..|:||.:.:
  Fly   444 ETAIWWTEYVLSHKGAAHMQVAGKDLGFVRYHSLDVFGTFLVGALVIL 491

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt301D1	NP_001246079.1	egt	12..483	CDD:223071	152/484 (31%)
Ugt301D1	NP_001246079.1	UDPGT	37..483	CDD:278624	142/458 (31%)
Ugt35D1	NP_651866.1	egt	1..462	CDD:223071	150/472 (32%)
Ugt35D1	NP_651866.1	UDPGT	30..511	CDD:278624	150/477 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	1	0.900	-	-		E33208_3BDT1
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	89	1.000	Inparanoid score	I2281
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm6444
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	9	8.860