DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt301D1 and ugt1ab

DIOPT Version :9

Sequence 1:	NP_001246079.1	Gene:	Ugt301D1 / 35105	FlyBaseID:	FBgn0032684	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_998587.2	Gene:	ugt1ab / 406731	ZFINID:	ZDB-GENE-040426-2762	Length:	536	Species:	Danio rerio

Alignment Length:	491	Identity:	146/491 - (29%)
Similarity:	244/491 - (49%)	Gaps:	64/491 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 SHWLWLEHFQNDLLRQGHHV------TSV-----NNHPTKHPHENLTEIIISPSFDIPKHFPKEN 90
            ||||.::....::..:||.:      ||:     .|..||             ||.:|..|.:.|
Zfish    47 SHWLSMKILVEEMSSRGHEMVVLVPETSILIGKSGNFTTK-------------SFRVPYSFDELN 98

  Fly    91 IF-----------SMQFVS---------DFNNLELWWTIGLMTTEHAFKDPKVKKLIESKDDHYD 135
            ..           :.:|:.         .|.|:::....||:     :.:|.:|.|   :|..:|
Zfish    99 AHVDHIRKTAIEKAPRFIDIVGALGNLIQFTNMQVKACEGLL-----YDEPLMKSL---RDMKFD 155

  Fly   136 LVIIEQFFHEAFLMFGKRFNCPVVTIGTMGYADNIDHAMG-ILTPWSLIPHLLLSHTDRMTFGQR 199
            .::.:.|. ....:....|:.|.|.. ..|....:|.|.. ..:|.|.||.....:||:|||.||
Zfish   156 ALLTDPFL-PCGSVIADYFSIPAVYF-LRGIPCRLDEAAAQCPSPPSFIPRFFTGYTDKMTFPQR 218

  Fly   200 AYNAYLSLYDAVMRRWVYLPKMQKLAEKYFQGSIEGPLPNVLDLERNISLVLINAHRSIDLPRPS 264
            ..|.::::::..:...:: ....:||.:|.:..     .:..:|..:.::.|:....|.:.|:|.
Zfish   219 MINTFMTVFEKYLCHQLF-ASFDELATRYLKKD-----TSYAELLGHGAVWLLRYDFSFEYPKPQ 277

  Fly   265 MPGLIDVGGAHIQKPKQLPTDLQNFLD-NATYGVIYFSMGSYVKSTDLPQEKTALILKAFGQLKQ 328
            ||.::.:||.:..|...|..:|:.|:: :..:|.:.|::||.|  :.||:.|.....:||.|:.|
Zfish   278 MPNMVQIGGINCAKRAPLTKELEEFVNGSGEHGFVVFTLGSMV--SQLPEAKAREFFEAFRQIPQ 340

  Fly   329 QVIWKFENDSIGDLPSNVMIKKWMPQNDILAHPNVKLFITHGGIFGTQEGIYWGVPMLCVPLYGD 393
            :|:|::......:.|.||.:.||:||||:|.||.|:.|:||||..|..|||..||||:.:||:||
Zfish   341 RVLWRYTGPVPENAPKNVKLMKWLPQNDLLGHPKVRAFVTHGGSHGIYEGICNGVPMVMLPLFGD 405

  Fly   394 QHRNTIKSVREGYARSLVFSKLTTDDLVRNIETLINDPQYKRSALEVSQRFRDNPIHPLDEATFW 458
            |..|..:.|..|.|.||....:|::.|:..::.:|||..||...:::|...||.||.|||.|.||
Zfish   406 QGDNAQRLVSRGVAESLTIYDVTSEKLLVALKKVINDKSYKEKMMKLSAIHRDRPIEPLDLAVFW 470

  Fly   459 IEYIIRHRGARHLKSHGAFIPLHQYLLLDVLGCLLL 494
            .|:::||:||.||:.....:...||..|||:|.|||
Zfish   471 TEFVMRHKGAEHLRPAAHDLNWIQYHSLDVIGFLLL 506

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt301D1	NP_001246079.1	egt	12..483	CDD:223071	137/478 (29%)
Ugt301D1	NP_001246079.1	UDPGT	37..483	CDD:278624	137/478 (29%)
ugt1ab	NP_998587.2	UDPGT	37..524	CDD:278624	146/491 (30%)
ugt1ab	NP_998587.2	egt	<279..513	CDD:223071	92/230 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	252	1.000	Domainoid score	I2043
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H128034
Inparanoid	1	1.050	252	1.000	Inparanoid score	I3189
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm6444
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	10	9.760