DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt301D1 and Ugt1a2

DIOPT Version :9

Sequence 1:	NP_001246079.1	Gene:	Ugt301D1 / 35105	FlyBaseID:	FBgn0032684	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_958826.1	Gene:	Ugt1a2 / 396527	RGDID:	1549741	Length:	533	Species:	Rattus norvegicus

Alignment Length:	549	Identity:	160/549 - (29%)
Similarity:	258/549 - (46%)	Gaps:	82/549 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 LIFLIGLLEFGAGSRILFMGPFPAP-SHWLWLEHFQNDLLRQGHHVTSVNNHPTKH--------- 66
            |:.|:..|.:..|.::|.   ||.. ||||.:.....:|..:||....:....|.|
  Rat    15 LLLLLCALPWAEGGKVLV---FPMEGSHWLSMRDVVRELHARGHQAVVLAPEVTVHMKGEDFFTL 76

  Fly    67 -----PH---ENLTEII--ISPSFDIPKHFPKENIFSMQFVSDFNNLELWWTIGLMTTEHAFKDP 121
                 |:   |...||:  ....|: |:||.|....:|..:..|.:|.......|:..
  Rat    77 QTYAFPYTKEEYQREILGNAKKGFE-PQHFVKTFFETMASIKKFFDLYANSCAALLHN------- 133

  Fly   122 KVKKLIES-KDDHYDLVIIEQFFHEAFLMFGKRFNCPVVTIGTMGYADNIDH-AMGILTPWSLIP 184
              |.||:. ....:|:|:.:..|....|: .|....|.|.. .......||: |.....|.|.||
  Rat   134 --KTLIQQLNSSSFDVVLTDPVFPCGALL-AKYLQIPAVFF-LRSVPCGIDYEATQCPKPSSYIP 194

  Fly   185 HLLLSHTDRMTFGQRAYNAYLSLYDAVMRRWVYL--PKMQKLAEKYFQGSIEGPLPNVLDLERNI 247
            :||...:|.|||.||..|   .||...::...:|  ...:.||.:.              |:|.:
  Rat   195 NLLTMLSDHMTFLQRVKN---MLYPLTLKYICHLSITPYESLASEL--------------LQREM 242

  Fly   248 SLVLINAHRSI---------DLPRPSMPGLIDVGGAHIQKPKQLPTDLQNFLD-NATYGVIYFSM 302
            |||.:.:|.|:         |.|||.||.::.:||.:....|.|..:.:.::: :..:|::.||:
  Rat   243 SLVEVLSHASVWLFRGDFVFDYPRPIMPNMVFIGGINCVIKKPLSQEFEAYVNASGEHGIVVFSL 307

  Fly   303 GSYVKSTDLPQEKTALILKAFGQLKQQVIWKFENDSIGDLPSNVMIKKWMPQNDILAHPNVKLFI 367
            ||.|  :::|::|...|.:|.|::.|.|:|::......:|..|.::.||:||||:|.||..:.||
  Rat   308 GSMV--SEIPEKKAMEIAEALGRIPQTVLWRYTGTRPSNLAKNTILVKWLPQNDLLGHPKARAFI 370

  Fly   368 THGGIFGTQEGIYWGVPMLCVPLYGDQHRNTIKSVREGYARSLVFSKLTTDDLVRNIETLINDPQ 432
            ||.|..|..|||..||||:.:||:|||..|..:....|...:|...::|.|||...::|:||:..
  Rat   371 THSGSHGIYEGICNGVPMVMMPLFGDQMDNAKRMETRGAGVTLNVLEMTADDLENALKTVINNKS 435

  Fly   433 YKRSALEVSQRFRDNPIHPLDEATFWIEYIIRHRGARHLKSHGAFIPLHQYLLLDVLGCLLLGAF 497
            ||.:.:.:|...:|.||.|||.|.||:||::||:||.||:.....:..:||..|||:|.||....
  Rat   436 YKENIMRLSSLHKDRPIEPLDLAVFWVEYVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAIVL 500

  Fly   498 LAIWLPWR--------------MIRRVHK 512
            ..:::.::              .:::.||
  Rat   501 TVVFIVYKSCAYGCRKCFGGKGRVKKSHK 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt301D1	NP_001246079.1	egt	12..483	CDD:223071	150/504 (30%)
Ugt301D1	NP_001246079.1	UDPGT	37..483	CDD:278624	143/478 (30%)
Ugt1a2	NP_958826.1	UDPGT	28..524	CDD:278624	154/529 (29%)
Ugt1a2	NP_958826.1	egt	<261..507	CDD:223071	91/247 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	256	1.000	Domainoid score	I1959
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	275	1.000	Inparanoid score	I2882
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm9018
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.860