DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt301D1 and Ugt1a6b

DIOPT Version :9

Sequence 1:	NP_001246079.1	Gene:	Ugt301D1 / 35105	FlyBaseID:	FBgn0032684	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_958812.3	Gene:	Ugt1a6b / 394435	MGIID:	3580629	Length:	531	Species:	Mus musculus

Alignment Length:	531	Identity:	143/531 - (26%)
Similarity:	251/531 - (47%)	Gaps:	95/531 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 SHWLWLEHFQNDLLRQGHHVTSVNNHPTKHPHENLTEIIISPSFDI----PKHFPKENIFSMQFV 97
            ||||.::.....|..:||.:                 :::.|..::    .|:: :..|||:.:
Mouse    37 SHWLSMKEIVEHLSERGHDI-----------------VVLVPEVNLLLGESKYY-RRKIFSVPY- 82

  Fly    98 SDFNNLELWWTIGLMTTEHAF-------KDPKVKKLIESKDDHYDLVIIEQFFHE---------- 145
                :||     .|.|....|       ..|.:..|.|.::   .::.:|.||..
Mouse    83 ----SLE-----ELQTRFRTFGRNQFVPGAPLMGPLREYRN---SMLTLEMFFSNCQSLLKDSAT 135

  Fly   146 -AFL---MFGKRFNCPVVTIGTM--------------GYADNIDHAMG-ILTPWSLIPHLLLSHT 191
             :||   .|...|..|.:..|.:              |:..:::|.:| ..:|.|.:|......:
Mouse   136 LSFLRENKFDALFTDPAMPCGVILAEYLNLPSVYLFRGFPCSLEHMLGQSPSPVSYVPRFYTKFS 200

  Fly   192 DRMTFGQRAYNAYLSLYDAVMRRWVYLPKMQKLAEKYFQGSIEGPLPNVLDLERNISLVLINAHR 256
            |.|||.||..|..:::.:..:...:| .|.:.:.....:..:..|     .|.:| ||.|:....
Mouse   201 DHMTFPQRLANFIVNILENYLYYCLY-SKYEIIVTDLLKRDVSLP-----SLHQN-SLWLLRYDF 258

  Fly   257 SIDLPRPSMPGLIDVGGAHIQKPKQLPTDLQNFLD-NATYGVIYFSMGSYVKSTDLPQEKTALIL 320
            ..:.|||.||.:|.:||.:.:|..:|..:.:.::: :..:|::.||:||.|  :::|::|...|.
Mouse   259 VFEYPRPIMPNMIFIGGINCKKKGKLTQEFEAYVNASGEHGIVVFSLGSMV--SEIPEKKAMEIA 321

  Fly   321 KAFGQLKQQVIWKFENDSIGDLPSNVMIKKWMPQNDILAHPNVKLFITHGGIFGTQEGIYWGVPM 385
            :|.|::.|.|:|::......:|..|.::.||:||||:|.||..:.||||.|..|..|||..||||
Mouse   322 EALGRIPQTVLWRYTGTRPSNLAKNTILVKWLPQNDLLGHPKTRAFITHSGSHGIYEGICNGVPM 386

  Fly   386 LCVPLYGDQHRNTIKSVREGYARSLVFSKLTTDDLVRNIETLINDPQYKRSALEVSQRFRDNPIH 450
            :.:||:|||..|..:....|...:|...::|.|||...::|:||:..||.:.:.:|...:|.||.
Mouse   387 VMMPLFGDQMDNAKRMETRGAGVTLNVLEMTADDLENALKTVINNKSYKENIMRLSSLHKDRPIE 451

  Fly   451 PLDEATFWIEYIIRHRGARHLKSHGAFIPLHQYLLLDVLGCLLLGAFLAIWLPWR---------- 505
            |||.|.||:||::||:||.||:.....:..:||..|||:|.||......:::.::
Mouse   452 PLDLAVFWVEYVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAIVLTVVFIVFKCCAYGCRKCF 516

  Fly   506 ----MIRRVHK 512
                .:::.||
Mouse   517 GGKGRVKKSHK 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt301D1	NP_001246079.1	egt	12..483	CDD:223071	133/486 (27%)
Ugt301D1	NP_001246079.1	UDPGT	37..483	CDD:278624	133/486 (27%)
Ugt1a6b	NP_958812.3	egt	15..503	CDD:223071	141/505 (28%)
Ugt1a6b	NP_958812.3	UDPGT	27..522	CDD:278624	141/524 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	259	1.000	Domainoid score	I1975
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	272	1.000	Inparanoid score	I2975
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm42461
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.760