DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt301D1 and Ugt1a9

DIOPT Version :9

Sequence 1:	NP_001246079.1	Gene:	Ugt301D1 / 35105	FlyBaseID:	FBgn0032684	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_964006.2	Gene:	Ugt1a9 / 394434	MGIID:	3576092	Length:	528	Species:	Mus musculus

Alignment Length:	546	Identity:	152/546 - (27%)
Similarity:	258/546 - (47%)	Gaps:	80/546 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 LIFLIGLLEFGAGSRILFMGPFPAPSHWLWLEHFQNDLLRQGHHVT----------------SVN 60
            |:...||.:.|   |:|.: |... |||..::.....|:.:||.|.                :|.
Mouse    14 LLLASGLAQAG---RLLVV-PMDG-SHWFTMQMVVEKLIHRGHEVVVVIPEVSWQLGKSLNCTVK 73

  Fly    61 NHPTKHPHENLTEIIISPSFDIPKHF----------PKENIFSMQFVSDFNNLELWWTIGLMTTE 115
            .:...|..|           |:.:.|          |:.:|.|....|.....||       |..
Mouse    74 TYSISHTLE-----------DLDREFKYLSYTQWKTPEHSIRSFLTGSARGFFEL-------TFS 120

  Fly   116 HA---FKDPKVKKLIE-SKDDHYDLVIIEQFFHEAFLMFGKRFNCPVVTIGTMGYADNIDHAMGI 176
            |.   |.|   |||:| .|...:|.|.::. |....|:..|.|:.|.|......:.|.::.....
Mouse   121 HCRSLFND---KKLVEYLKQRFFDAVFLDP-FDVCGLIVAKYFSLPSVIFARGVFCDYLEEGAQC 181

  Fly   177 LTPWSLIPHLLLSHTDRMTFGQRAYNAYLSLYDAVMRRWVYLPKMQKLAEKYFQGSIEGPLPNVL 241
            .:..|.:|.|...:||.|||.:|.:|..:.:.:.....: :|....::|.:..|..:     .:.
Mouse   182 PSLPSYVPRLFSKYTDTMTFKERVWNHLIYIEEHAFCSY-FLRTAVEVASEILQTPV-----TMT 240

  Fly   242 DLERNISLVLINAHRSIDLPRPSMPGLIDVGGAHIQKPKQLPTDLQNFLD-NATYGVIYFSMGSY 305
            ||...:|:.|:.....::.|||.||.::.:||.:..:.|.|..:.:.::: :..:|::.||:||.
Mouse   241 DLFSPVSIWLLRTDFVLEFPRPVMPNMVFIGGINCLQKKSLSKEFEAYVNASGEHGIVVFSLGSM 305

  Fly   306 VKSTDLPQEKTALILKAFGQLKQQVIWKFENDSIGDLPSNVMIKKWMPQNDILAHPNVKLFITHG 370
            |  :::|::|...|.:|.|::.|.|:|::......:|..|.::.||:||||:|.||..:.||||.
Mouse   306 V--SEIPEKKAMEIAEALGRIPQTVLWRYTGTRPSNLAKNTILVKWLPQNDLLGHPKTRAFITHS 368

  Fly   371 GIFGTQEGIYWGVPMLCVPLYGDQHRNTIKSVREGYARSLVFSKLTTDDLVRNIETLINDPQYKR 435
            |..|..|||..||||:.:||:|||..|..:....|...:|...::|.|||...::|:||:..||.
Mouse   369 GSHGIYEGICNGVPMVMMPLFGDQMDNAKRMETRGAGVTLNVLEMTADDLENALKTVINNKSYKE 433

  Fly   436 SALEVSQRFRDNPIHPLDEATFWIEYIIRHRGARHLKSHGAFIPLHQYLLLDVLGCLLLGAFLAI 500
            :.:.:|...:|.||.|||.|.||:||::||:||.||:.....:..:||..|||:|.||......:
Mouse   434 NIMRLSSLHKDRPIEPLDLAVFWVEYVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAIVLTVV 498

  Fly   501 WLPWR--------------MIRRVHK 512
            ::.::              .:::.||
Mouse   499 FIVFKCCAYGCRKCFGGKGRVKKSHK 524

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt301D1	NP_001246079.1	egt	12..483	CDD:223071	142/501 (28%)
Ugt301D1	NP_001246079.1	UDPGT	37..483	CDD:278624	135/476 (28%)
Ugt1a9	NP_964006.2	egt	9..500	CDD:223071	150/520 (29%)
Ugt1a9	NP_964006.2	UDPGT	24..519	CDD:278624	147/529 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	259	1.000	Domainoid score	I1975
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	272	1.000	Inparanoid score	I2975
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm42461
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.760