DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt301D1 and Ugt1a7c

DIOPT Version :9

Sequence 1:	NP_001246079.1	Gene:	Ugt301D1 / 35105	FlyBaseID:	FBgn0032684	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_964004.1	Gene:	Ugt1a7c / 394432	MGIID:	3032636	Length:	531	Species:	Mus musculus

Alignment Length:	551	Identity:	161/551 - (29%)
Similarity:	257/551 - (46%)	Gaps:	83/551 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 CWMLIFLIGLLEFGAGSRILFMGPFPAPSHWLWLEHFQNDLLRQGHHVT---------------- 57
            |..|:...||.:.|   |:|.: |... |||..::.....||.:||.|.
Mouse    13 CVCLLLASGLAQAG---RLLVV-PMDG-SHWFTMQTVVEKLLHKGHEVVVVVPEVSWQLTKPLNF 72

  Fly    58 SVNNHPTKHPHENLT---EIIIS------------PSFDIPKHFPKENIFSMQFVSDFNNLELWW 107
            .|..:...|..|:|.   :|.|.            |..|    .|.:..|.:.| |...:|
Mouse    73 VVKTYAVSHTQEDLNREFKIFIDAQWKSQQEGGILPLLD----SPAKGFFELLF-SHCRSL---- 128

  Fly   108 TIGLMTTEHAFKDPKVKKLIE-SKDDHYDLVIIEQFFHEAFLMFGKRFNCPVVTIGTMGYADNID 171
                      |.|   |||:| .|...:|.|.::. |....|...|.|:.|.|......:...::
Mouse   129 ----------FND---KKLVEYLKQTSFDAVFLDP-FDVCGLTVAKYFSLPSVVFSRGIFCHYLE 179

  Fly   172 HAMGILTPWSLIPHLLLSHTDRMTFGQRAYNAYLSLYDAVMRRWVYLPKMQKLAEKYFQGSIEGP 236
            .|....:|.|.||.:||..||.|||.:|..|..     |.|....:..|..|.|.......::.|
Mouse   180 DAAQCPSPPSYIPRMLLKFTDTMTFKERTRNLL-----AYMGERAFCHKFFKSAADIASEVLQTP 239

  Fly   237 LPNVLDLERNISLVLINAHRSIDLPRPSMPGLIDVGGAHIQKPKQLPTDLQNFLD-NATYGVIYF 300
            : .:.||...:|:.|:.....::.|||.||.:|.:||.:..:.|.|..:.:.::: :..:|::.|
Mouse   240 V-TMTDLFSPVSIWLLRTDFVLEFPRPVMPNVIYIGGINCHQGKPLSKEFEAYVNASGEHGIVVF 303

  Fly   301 SMGSYVKSTDLPQEKTALILKAFGQLKQQVIWKFENDSIGDLPSNVMIKKWMPQNDILAHPNVKL 365
            |:||.|  :::|::|...|.:|.|::.|.|:|::......:|..|.::.||:||||:|.||..:.
Mouse   304 SLGSMV--SEIPEKKAMEIAEALGRIPQTVLWRYTGTRPSNLAKNTILVKWLPQNDLLGHPKTRA 366

  Fly   366 FITHGGIFGTQEGIYWGVPMLCVPLYGDQHRNTIKSVREGYARSLVFSKLTTDDLVRNIETLIND 430
            ||||.|..|..|||..||||:.:||:|||..|..:....|...:|...::|.|||...::|:||:
Mouse   367 FITHSGSHGIYEGICNGVPMVMMPLFGDQMDNAKRMETRGAGVTLNVLEMTADDLENALKTVINN 431

  Fly   431 PQYKRSALEVSQRFRDNPIHPLDEATFWIEYIIRHRGARHLKSHGAFIPLHQYLLLDVLGCLLLG 495
            ..||.:.:.:|...:|.||.|||.|.||:||::||:||.||:.....:..:||..|||:|.||..
Mouse   432 KSYKENIMRLSSLHKDRPIEPLDLAVFWVEYVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAI 496

  Fly   496 AFLAIWLPWR--------------MIRRVHK 512
            ....:::.::              .:::.||
Mouse   497 VLTVVFIVFKCCAYGCRKCFGGKGRVKKSHK 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt301D1	NP_001246079.1	egt	12..483	CDD:223071	150/503 (30%)
Ugt301D1	NP_001246079.1	UDPGT	37..483	CDD:278624	143/478 (30%)
Ugt1a7c	NP_964004.1	UDPGT	26..522	CDD:278624	155/531 (29%)
Ugt1a7c	NP_964004.1	egt	<225..503	CDD:223071	98/280 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	259	1.000	Domainoid score	I1975
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	272	1.000	Inparanoid score	I2975
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm42461
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.760