DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt301D1 and Ugt37A1

DIOPT Version :9

Sequence 1:	NP_001246079.1	Gene:	Ugt301D1 / 35105	FlyBaseID:	FBgn0032684	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_523607.2	Gene:	Ugt37A1 / 35307	FlyBaseID:	FBgn0026756	Length:	522	Species:	Drosophila melanogaster

Alignment Length:	547	Identity:	170/547 - (31%)
Similarity:	275/547 - (50%)	Gaps:	60/547 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 WMLIFLIGLLEFGA-GSRILFMGPFPAPSHWLWLEHFQNDLLRQGHHVTSVNNHPTKHPHENLTE 73
            ::::..:.||.:|| |:.||.:.|..:|||.:........|..|||:||.|........|:|:..
  Fly     9 FVIVLALTLLIYGAQGANILGLFPSLSPSHLIISMSVAKILAEQGHNVTVVTVLEPTITHKNINL 73

  Fly    74 IIISPSFDIPKH------FPKENIFSMQFVSDFNNLELWWTIGLMTT-----EHAFKDPKVKKLI 127
            :.:..:.:..|.      ..::|..|.:|:|..|      ..|.|.:     ....||.:||:|.
  Fly    74 VTVPMTKEEIKQRSETIGAKQKNTSSNRFISILN------MSGQMDSMLRKMADVLKDQRVKELY 132

  Fly   128 ESKDDHYDLVIIEQFFHEAFLMFGKRFNCPVVTIGTMGYADNIDHAMGILTPWSLIPHLLLSHTD 192
            .:||:|:||||...|.::..|.|.::.|.|||.:.....:..::..:|       .||..:....
  Fly   133 LNKDNHFDLVISGYFMNDYQLGFARKVNAPVVVLAPSPPSQMLNSLIG-------NPHDKVEKEK 190

  Fly   193 RMTFGQRAYNAYLS--LYDAVMRRWVYLPKMQKLAEKYFQGSIEG---PLPNVLDLERNISLVLI 252
            .|||||| .::|:|  ||.      ::|.::.:...:|: ..|.|   .:|...|:.||.|||..
  Fly   191 GMTFGQR-LDSYISSLLYG------IFLRQIDQRNRQYY-NEIFGDDPTMPEYTDILRNTSLVFF 247

  Fly   253 NAHRSIDLP-RPSMPGLIDVGGAHIQ-KPKQLPTDLQNFLDNATYGVIYFSMGSYVKSTDLPQEK 315
            .:|.:.:.| |||:|..|::||..|: ||..||.:|:.||.|||:|.|..|:||.|:.:.:..:.
  Fly   248 CSHAASEGPIRPSVPAAIEIGGIQIKDKPDPLPKNLEKFLGNATHGAILLSLGSNVQGSHIKADT 312

  Fly   316 TALILKAFGQLKQQVIWKFEN-DSIGDLPSNVMIKKWMPQNDILAHPNVKLFITHGGIFGTQEGI 379
            ...|......|||:||||::: |.......|::..:|:||:||||||:|||||.|.|..|..|..
  Fly   313 VKKIFSVLSNLKQRVIWKWDDLDKTPGKSDNILYSRWLPQDDILAHPSVKLFINHAGKGGISEAQ 377

  Fly   380 YWGVPMLCVPLYGDQHRNTIKSVREGYARSLVFSKLTTDDLVRNIETLINDPQYKRSALEVSQRF 444
            |.|.|||.:|::|||..|....|:.|:..:|....|..:.....:..::::|:|.:..::.|..:
  Fly   378 YHGKPMLSLPVFGDQPGNAHAMVKSGFGLTLSLLTLEEEPFRAAVLEILSNPKYSQRVVKFSSLY 442

  Fly   445 RDNPIHPLDEATFWIEYIIRHRGARHLKS---HGAFIPLHQYLLLDVLGCLLLGAFL----AIWL 502
            ||.|....:...||.||:|||.||.||:|   |..||..:...:..::|.:.:|..|    .:.:
  Fly   443 RDRPASARESLIFWTEYVIRHHGAAHLQSPLVHMDFIAANNLDIYALIGAISIGLLLMLKKVVQI 507

  Fly   503 PWRMIRRVHKWWLKGESSNKLNEGKKR 529
            ..|.:|            .|||:.||:
  Fly   508 TCRRLR------------TKLNKVKKQ 522

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt301D1	NP_001246079.1	egt	12..483	CDD:223071	160/493 (32%)
Ugt301D1	NP_001246079.1	UDPGT	37..483	CDD:278624	151/467 (32%)
Ugt37A1	NP_523607.2	GT1_Gtf-like	25..456	CDD:340817	140/451 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm14789
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	6	6.010