DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt301D1 and Ugt2b15

DIOPT Version :9

Sequence 1:	NP_001246079.1	Gene:	Ugt301D1 / 35105	FlyBaseID:	FBgn0032684	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_695226.3	Gene:	Ugt2b15 / 266685	RGDID:	628623	Length:	530	Species:	Rattus norvegicus

Alignment Length:	536	Identity:	160/536 - (29%)
Similarity:	258/536 - (48%)	Gaps:	86/536 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 SHWLWLEHFQNDLLRQGHHVTSVNNHPTKHPHENLTEIIISPS----FDIPKHFP--KENIFSMQ 95
            |||:.::...::|:::||.||                 ::.||    .| ||..|  |...|...
  Rat    34 SHWMNIKTILDELVQRGHEVT-----------------VLKPSAYYVLD-PKKSPDLKFETFPTS 80

  Fly    96 FVSD-----FNNLELWWTIGLMTTEHAFKDPKVKKLIESKDDHY-----DLV------------- 137
            ...|     |..|...||..|.........|.::.:|:...|:|     |.|
  Rat    81 VSKDELENYFIKLVDVWTYELQRDTCLSYSPLLQNMIDGFSDYYLSLCKDTVSNKQLMAKLQESK 145

  Fly   138 --------------IIEQFFHEAFLMFGKRFNCPVVTIGTMGYADNIDHAMG-ILTPWSLIPHLL 187
                          :|.:..|..|| :..||        :.||  .|:.:.| .:.|.|.:|.:|
  Rat   146 FDVLLSDPVAACGELIAEVLHIPFL-YSLRF--------SPGY--KIEKSSGRFILPPSYVPVIL 199

  Fly   188 LSHTDRMTFGQRAYNAYLSLYDAVMRRWVYLPKMQKLAEKY--FQGSIEGPLPNVLDLERNISLV 250
            ......|||..|..|...:||   ...|.::..    |:|:  |...|.|....:.:......:.
  Rat   200 SGMGGPMTFIDRVKNMICTLY---FDFWFHMFN----AKKWDPFYSEILGRPTTLAETMGKAEMW 257

  Fly   251 LINAHRSIDLPRPSMPGLIDVGGAHIQKPKQLPTDLQNFLDNA-TYGVIYFSMGSYVKSTDLPQE 314
            ||.::..::.|.|::|.:..:||...:.||.||.|:::|:.:: .:||:.||:||.|.|  :.:|
  Rat   258 LIRSYWDLEFPHPTLPNVDYIGGLQCRPPKPLPKDMEDFVQSSGEHGVVVFSLGSMVSS--MTEE 320

  Fly   315 KTALILKAFGQLKQQVIWKFENDSIGDLPSNVMIKKWMPQNDILAHPNVKLFITHGGIFGTQEGI 379
            |...|..|..|:.|:|:|||:..:...|..|..:.||:||||:|.||..|.|:||||..|..|.|
  Rat   321 KANAIAWALAQIPQKVLWKFDGKTPATLGPNTRVYKWLPQNDLLGHPKTKAFVTHGGANGVYEAI 385

  Fly   380 YWGVPMLCVPLYGDQHRNTIKSVREGYARSLVFSKLTTDDLVRNIETLINDPQYKRSALEVSQRF 444
            |.|:||:.:|::|:||.|....|.:|.|.:|....::..||...::.:||:|.||::|:.:|...
  Rat   386 YHGIPMVGIPMFGEQHDNIAHMVAKGAAVTLNIRTMSKSDLFNALKEIINNPFYKKNAVWLSTIH 450

  Fly   445 RDNPIHPLDEATFWIEYIIRHRGARHLKSHGAFIPLHQYLLLDVLGCLLLGAFLAIWLPWRMIRR 509
            .|.|:.|||:|.||||:::||:||:||:..|..:|.:||..|||:|.||..:.:...|..:....
  Rat   451 HDQPMKPLDKAVFWIEFVMRHKGAKHLRPLGHNLPWYQYHSLDVIGFLLTCSAVIAVLTVKSFLF 515

  Fly   510 VHKWWLKGESSNKLNE 525
            :::.::|.|...| ||
  Rat   516 IYRLFVKKEKKMK-NE 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt301D1	NP_001246079.1	egt	12..483	CDD:223071	146/492 (30%)
Ugt301D1	NP_001246079.1	UDPGT	37..483	CDD:278624	146/492 (30%)
Ugt2b15	NP_695226.3	UDPGT	24..527	CDD:278624	157/530 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	256	1.000	Domainoid score	I1959
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	275	1.000	Inparanoid score	I2882
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm9018
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.760