DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt301D1 and Ugt2b

DIOPT Version :9

Sequence 1:	NP_001246079.1	Gene:	Ugt301D1 / 35105	FlyBaseID:	FBgn0032684	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_113721.5	Gene:	Ugt2b / 24862	RGDID:	3936	Length:	530	Species:	Rattus norvegicus

Alignment Length:	531	Identity:	158/531 - (29%)
Similarity:	254/531 - (47%)	Gaps:	76/531 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 SHWLWLEHFQNDLLRQGHHVTSVNNHPTKHPHENLTEIIISPS---FDIPKHFP--KENIFSMQF 96
            |||:.::...::|:::||.||                 ::.||   |..||...  |..|||...
  Rat    34 SHWMNIKIILDELVQRGHEVT-----------------VLKPSAYFFLDPKKSSDLKFEIFSTSI 81

  Fly    97 VSD-----FNNLELWWTIGLMTTEHAFKDPKVKKLIESKDDHYDLVIIEQFFHEAFLM------- 149
            ..|     |..|...||..|.........|.::.|: .:..::.|.|.:.......||
  Rat    82 SKDELQNHFIKLLDVWTYELPRDTCLSYSPILQNLV-YEFSYFYLSICKDAVSNKQLMTKLQESK 145

  Fly   150 FGKRFNCPVVTIGTM-----------------GYADNIDHAMG-ILTPWSLIPHLLLSHTDRMTF 196
            |...|..||.:.|.:                 |:  .::.::| .:.|.|.:|.:|.....:|||
  Rat   146 FDVLFADPVASCGDLIAELLHIPFLYSLSFSPGH--KLEKSIGKFILPPSYVPVILSGLAGKMTF 208

  Fly   197 GQRAYN----AYLSLYDAVMR--RWVYLPKMQKLAEKYFQGSIEGPLPNVLDLERNISLVLINAH 255
            ..|..|    .|...:..::|  .|           ..|...|.|....|.:....:.:.||.::
  Rat   209 IDRVKNMICMLYFDFWFEILRHKEW-----------DTFYSEILGRPTTVDETMSKVEIWLIRSY 262

  Fly   256 RSIDLPRPSMPGLIDVGGAHIQKPKQLPTDLQNFLDNA-TYGVIYFSMGSYVKSTDLPQEKTALI 319
            ..:..|.|::|.:..:||.|.:..|.||.|::.|:.:: .:||:.||:||.|  :::.:||...|
  Rat   263 WDLKFPHPTLPNVDYIGGLHCKPAKPLPKDMEEFVQSSGEHGVVVFSLGSMV--SNMTEEKANAI 325

  Fly   320 LKAFGQLKQQVIWKFENDSIGDLPSNVMIKKWMPQNDILAHPNVKLFITHGGIFGTQEGIYWGVP 384
            ..|..|:.|:|:|||:..:...|..|..:.||:||||||.||..|.|:||||..|..|.||.|:|
  Rat   326 AWALAQIPQKVLWKFDGKTPATLGPNTRVYKWLPQNDILGHPKTKAFVTHGGANGLYEAIYHGIP 390

  Fly   385 MLCVPLYGDQHRNTIKSVREGYARSLVFSKLTTDDLVRNIETLINDPQYKRSALEVSQRFRDNPI 449
            |:.:||:|||..|....|.:|.|.||....::..|.:..:|.:|::|.||::.:.:|....|.|:
  Rat   391 MIGIPLFGDQPDNIAHMVAKGAAVSLNIRTMSKLDFLSALEEVIDNPFYKKNVMLLSTIHHDQPM 455

  Fly   450 HPLDEATFWIEYIIRHRGARHLKSHGAFIPLHQYLLLDVLGCLLLGAFLAIWLPWRMIRRVHKWW 514
            .|||.|.||||:|:||:||:||:..|..:|.:||..|||:|.||....:...|..:.:..:::::
  Rat   456 KPLDRAVFWIEFIMRHKGAKHLRPLGHNLPWYQYHSLDVIGFLLTCFAVIAALTVKCLLFMYRFF 520

  Fly   515 LKGESSNKLNE 525
            :|.|...| ||
  Rat   521 VKKEKKMK-NE 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt301D1	NP_001246079.1	egt	12..483	CDD:223071	144/487 (30%)
Ugt301D1	NP_001246079.1	UDPGT	37..483	CDD:278624	144/487 (30%)
Ugt2b	NP_113721.5	UDPGT	24..527	CDD:278624	155/525 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	256	1.000	Domainoid score	I1959
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	275	1.000	Inparanoid score	I2882
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm9018
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.860