DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt301D1 and Ugt1a1

DIOPT Version :9

Sequence 1:	NP_001246079.1	Gene:	Ugt301D1 / 35105	FlyBaseID:	FBgn0032684	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_036815.1	Gene:	Ugt1a1 / 24861	RGDID:	3935	Length:	535	Species:	Rattus norvegicus

Alignment Length:	543	Identity:	151/543 - (27%)
Similarity:	259/543 - (47%)	Gaps:	69/543 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 MLIFLIGLLEFGAGSRILFMGPFPAPSHWLWLEHFQNDLLRQGHHVT----------------SV 59
            :|:.::|.....||.  |.:.|... ||||.:......|.::||.|.                ::
  Rat    17 LLLCVLGPSASHAGK--LLVIPIDG-SHWLSMLGVIQQLQQKGHEVVVIAPEASIHIKEGSFYTM 78

  Fly    60 NNHPTKHPHENLTEIIISPSFDIPKHFPKENIFSMQFVSDFNNLELWWTIGLMTTEHAFKDPKVK 124
            ..:|....:||:|...:    ::.:....::.|.::.|..:|.::...::.|....|...:.:..
  Rat    79 RKYPVPFQNENVTAAFV----ELGRSVFDQDPFLLRVVKTYNKVKRDSSMLLSGCSHLLHNAEFM 139

  Fly   125 KLIESKDDHYDLV----------IIEQFFHEAFLMFGKRFNCPVVTIGTMGYADNIDHAMGILTP 179
            ..:|  ..|:|.:          |:.|:.....:.|.....|.:....|...|           |
  Rat   140 ASLE--QSHFDALLTDPFLPCGSIVAQYLSLPAVYFLNALPCSLDLEATQCPA-----------P 191

  Fly   180 WSLIPHLLLSHTDRMTFGQRAYNAYLSLYDAVMRRWVYLPKMQKLAEKYFQGSIEGPLPNVLDLE 244
            .|.:|..|.|:||||.|.||..|..::|.:..:.|.||.| ...||.:..|..:     .|.||.
  Rat   192 LSYVPKSLSSNTDRMNFLQRVKNMIIALTENFLCRVVYSP-YGSLATEILQKEV-----TVKDLL 250

  Fly   245 RNISLVLINAHRSIDLPRPSMPGLIDVGGAHIQKPKQLPTDLQNFLD-NATYGVIYFSMGSYVKS 308
            ...|:.|:......|.|||.||.::.:||.:..:.|.|..:.:.::: :..:|::.||:||.|
  Rat   251 SPASIWLMRNDFVKDYPRPIMPNMVFIGGINCLQKKALSQEFEAYVNASGEHGIVVFSLGSMV-- 313

  Fly   309 TDLPQEKTALILKAFGQLKQQVIWKFENDSIGDLPSNVMIKKWMPQNDILAHPNVKLFITHGGIF 373
            :::|::|...|.:|.|::.|.|:|::......:|..|.::.||:||||:|.||..:.||||.|..
  Rat   314 SEIPEKKAMEIAEALGRIPQTVLWRYTGTRPSNLAKNTILVKWLPQNDLLGHPKARAFITHSGSH 378

  Fly   374 GTQEGIYWGVPMLCVPLYGDQHRNTIKSVREGYARSLVFSKLTTDDLVRNIETLINDPQYKRSAL 438
            |..|||..||||:.:||:|||..|..:....|...:|...::|.|||...::|:||:..||.:.:
  Rat   379 GIYEGICNGVPMVMMPLFGDQMDNAKRMETRGAGVTLNVLEMTADDLENALKTVINNKSYKENIM 443

  Fly   439 EVSQRFRDNPIHPLDEATFWIEYIIRHRGARHLKSHGAFIPLHQYLLLDVLGCLLLGAFLAIWLP 503
            .:|...:|.||.|||.|.||:||::||:||.||:.....:..:||..|||:|.||......:::.
  Rat   444 RLSSLHKDRPIEPLDLAVFWVEYVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAIVLTVVFIV 508

  Fly   504 WR--------------MIRRVHK 512
            ::              .:::.||
  Rat   509 YKSCAYGCRKCFGGKGRVKKSHK 531

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt301D1	NP_001246079.1	egt	12..483	CDD:223071	141/497 (28%)
Ugt301D1	NP_001246079.1	UDPGT	37..483	CDD:278624	135/472 (29%)
Ugt1a1	NP_036815.1	UDPGT	30..526	CDD:278624	146/523 (28%)
Ugt1a1	NP_036815.1	egt	<263..509	CDD:223071	91/247 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	256	1.000	Domainoid score	I1959
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H128034
Inparanoid	1	1.050	275	1.000	Inparanoid score	I2882
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm9018
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.760