DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt301D1 and Ugt50B3

DIOPT Version :9

Sequence 1:	NP_001246079.1	Gene:	Ugt301D1 / 35105	FlyBaseID:	FBgn0032684	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_001260710.1	Gene:	Ugt50B3 / 246614	FlyBaseID:	FBgn0050438	Length:	524	Species:	Drosophila melanogaster

Alignment Length:	533	Identity:	148/533 - (27%)
Similarity:	258/533 - (48%)	Gaps:	65/533 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 WKCWMLIFLIGLLEFGAGSRILFMGPFPAPSHWLWLEHFQNDLLRQGHHVTSVNNHPTKHPHENL 71
            |.|..|...| |:....|::          ||.:........|:.:||::|.::..|.....|.|
  Fly    12 WSCGTLAADI-LMATQGGTK----------SHKIPFWELAKGLISRGHNITFLSGFPADFNIEGL 65

  Fly    72 TEIIISPSFDIPKHFPKENIFSMQFVSDFNNLELW------------WTIGLMTTEHAF------ 118
            .|  ::|:            ..::::.::.|.:|.            |. ||   .:||
  Fly    66 LE--VTPA------------GLVEYIHNYTNWDLLGSRMAGEMPIKPWD-GL---RYAFESCDAM 112

  Fly   119 -KDPKVKKLIESKDDHYDLVIIEQFFHEAFLMFGKRFNCPVVTIGTMGYADNIDHAMGILTPWSL 182
             :|.:.|:|.:..   :||.|::..|.|.||.....|..|.:.|.|:|:........|....:::
  Fly   113 LRDSETKELTKKS---FDLAILDGAFPECFLGLMYDFKIPFMYINTVGFYTGSISTAGNPVSYAI 174

  Fly   183 IPHLLLSHTDRMTFGQRAYNAYLSLYDAVMRRWVYLPKMQKLAEKYFQGSIEGPLPNVLDLERNI 247
            .|:.....||.|...:||.|..:.:...:|.  :|:.:...|..:...|:   .:|:..::.||:
  Fly   175 TPNFYSRFTDTMNLYERAINTAMQIGQTLMH--MYVMRRTHLVMREHLGT---QIPHPYEMSRNV 234

  Fly   248 SLVLINAHRSIDLPRPSMPGLIDVGGAHIQKPKQLPTDLQNFLD-NATYGVIYFSMGSYVKSTDL 311
            |.:|.|.|..:..||...|.:.:|...|.:..::||.:|:.|:. :...|.||.||||.||:.::
  Fly   235 SFILQNGHAVLSYPRAFNPNVAEVACIHCRPARKLPRNLEEFIGASGASGFIYVSMGSSVKAANM 299

  Fly   312 PQEKTALILKAFGQLKQQVIWKFENDS--IGDLPSNVMIKKWMPQNDILAHPNVKLFITHGGIFG 374
            |:....:::|.|.:|...|:||:|..|  |.|:.|||.:.:|:||.|||.||.::.|:||||:..
  Fly   300 PEALRHMLVKTFARLPYHVLWKYEGSSTDIKDITSNVKLSRWLPQQDILGHPKLRAFVTHGGLLS 364

  Fly   375 TQEGIYWGVPMLCVPLYGDQHRNTIKSVREGYARSLVFSKLTTDDLVRNIETLINDPQYKRSALE 439
            ..|.:|.|||::.:|::.|...|:.|:..:|||..|....|:.:.|.:.|..:|::|:|:.||..
  Fly   365 MFETVYHGVPVVTMPVFCDHDVNSAKAEVDGYAIKLDLQTLSANQLYKAIMKVIHNPRYRNSARH 429

  Fly   440 VSQRFRDNPIHPLDEATFWIEYIIRHRGARHLKSHGAFIPLHQYLLLDVLGCLLLGAFLAIW--- 501
            ..:.|.|.....||.|.:|.||::||.||.||::....:...||.||||:...|:..::.|.
  Fly   430 RQKLFLDQRSTALDTAIYWTEYVLRHNGAYHLQTPSRNMTWWQYYLLDVVAVYLILLYVLILALR 494

  Fly   502 ---LPWRMIRRVH 511
               .|:..:|.::
  Fly   495 RIDFPYEKVRSLY 507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt301D1	NP_001246079.1	egt	12..483	CDD:223071	136/492 (28%)
Ugt301D1	NP_001246079.1	UDPGT	37..483	CDD:278624	132/467 (28%)
Ugt50B3	NP_001260710.1	YjiC	28..434	CDD:224732	119/441 (27%)
Ugt50B3	NP_001260710.1	egt	<172..479	CDD:223071	103/311 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	172	1.000	Inparanoid score	I2735
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm42461
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	8	7.960