DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt301D1 and Ugt3a2

DIOPT Version :9

Sequence 1:	NP_001246079.1	Gene:	Ugt301D1 / 35105	FlyBaseID:	FBgn0032684	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_659094.1	Gene:	Ugt3a2 / 223337	MGIID:	2145969	Length:	523	Species:	Mus musculus

Alignment Length:	542	Identity:	148/542 - (27%)
Similarity:	245/542 - (45%)	Gaps:	58/542 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MEMQLQWKCWMLIFL-IGLLEFGAGSRILFMGPFPAPSHWLWLEHFQNDLLRQGHHVTSVNNHPT 64
            |....:|.....:|| :.|||   .::||.:....| ||::.:......|...||:||.:.....
Mouse     1 MAAHRRWLLMSFLFLEVILLE---AAKILTISTLSA-SHYIVISRVSQVLHEGGHNVTKLLYESA 61

  Fly    65 KHPHENLTEIIISPSFDIPKHFPKENIFSMQFVSDFNNLELWWTIG------LMTTEHAFKDPKV 123
            ..|.....:    ||:.:....|.|: ...:|....:.|....|.|      |:.....|.| ..
Mouse    62 NIPDFRKEK----PSYQVINWRPPED-QEKKFADLRHRLTEEITYGRSKHHTLLKIHQYFGD-LC 120

  Fly   124 KKLIESKD-------DHYDLVIIEQFFHEAFLM---FGKRFNCPVVTI--GTMGYADNIDHAMGI 176
            .:|:..||       :::|||:::.....:.|:   .||||    |:.  ....|.|     .|:
Mouse   121 SQLLSRKDIMDFLKNENFDLVLLDSMDLCSLLIVEKLGKRF----VSFLPFQFSYMD-----FGL 176

  Fly   177 -LTPWSLIPHLLLSHTDRMTFGQRAYNAYLSLYDAVMRRWVYLPKMQKLAEKYFQGSIEGPLPNV 240
             ..|.|..|......||:|.|..|..| :|...|..|::...|.:.....:::|   :||..|.:
Mouse   177 PSAPLSYAPVYGSGLTDQMDFWGRVKN-FLMFLDFSMKQREILSQYDSTIQEHF---VEGSQPVL 237

  Fly   241 LDLERNISLVLINAHRSIDLPRPSMPGLIDVGGAHIQKPKQ-LPTDLQNFLDN-ATYGVIYFSMG 303
            .||.....|..:|:..::|..||..|..:.|||. :.||.| :|.||:||:.. ...|.:..::|
Mouse   238 SDLLLKAELWFVNSDFALDFARPLFPNTVYVGGL-LDKPVQPIPQDLENFISQFGDSGFVLVALG 301

  Fly   304 SYV---KSTDLPQEKTALILKAFGQLKQQVIWKFEND---SIGDLPSNVMIKKWMPQNDILAHPN 362
            |.|   :|.::.:|..:    ||..|.|.|:|..:..   ....|..||.|..|:||.|:||||:
Mouse   302 SIVSMIQSKEIIKEMNS----AFAHLPQGVLWTCKTSHWPKDVSLAPNVKIMDWLPQTDLLAHPS 362

  Fly   363 VKLFITHGGIFGTQEGIYWGVPMLCVPLYGDQHRNTIKSVREGYARSLVFSKLTTDDLVRNIETL 427
            ::||:||||:....|.::.||||:.:|.:.||..|.::...:....|:....|..:.....::.:
Mouse   363 IRLFVTHGGMNSVMEAVHHGVPMVGIPFFFDQPENMVRVEAKNLGVSIQLQTLKAESFALTMKKI 427

  Fly   428 INDPQYKRSALEVSQRFRDNPIHPLDEATFWIEYIIRHRGARHLKSHGAFIPLHQYLLLDVLGCL 492
            |.|.:||.:|:........:|:.|......||::|::..||.|||.:....|.|:..:|||. ..
Mouse   428 IEDKRYKSAAMASKIIRHSHPLTPAQRLLGWIDHILQTGGAAHLKPYAFQQPWHEQYMLDVF-LF 491

  Fly   493 LLGAFL-AIWLPWRMIRRVHKW 513
            |||..| .:||..:::..|.::
Mouse   492 LLGLMLGTLWLSVKVLVAVTRY 513

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt301D1	NP_001246079.1	egt	12..483	CDD:223071	136/498 (27%)
Ugt301D1	NP_001246079.1	UDPGT	37..483	CDD:278624	128/472 (27%)
Ugt3a2	NP_659094.1	UDPGT	23..488	CDD:278624	132/489 (27%)
Ugt3a2	NP_659094.1	egt	<235..488	CDD:223071	79/257 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.810