DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt301D1 and Ugt8a

DIOPT Version :9

Sequence 1:	NP_001246079.1	Gene:	Ugt301D1 / 35105	FlyBaseID:	FBgn0032684	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_035804.2	Gene:	Ugt8a / 22239	MGIID:	109522	Length:	541	Species:	Mus musculus

Alignment Length:	566	Identity:	159/566 - (28%)
Similarity:	275/566 - (48%)	Gaps:	94/566 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 WMLIF-LIGLLEFGAGSRILFMGPFPAPSHWLWLEHFQNDLLRQGHHVTSVNNHPTKHPHENLTE 73
            :||:: .:|:   ...::|:.:.|....||....:...:.|..:|||                |.
Mouse     8 FMLLWSAVGI---ARAAKIIIVPPIMFESHLYIFKTLASALHERGHH----------------TV 53

  Fly    74 IIISPSFDIPKHFPKENIFSMQ-FVSDFNNLELWWTIGLMTTEHAFKDPKVKKLIESKDDHYDLV 137
            :::|...||    ...|.:|:| :...||:          ||..||...|::.:...:....:||
Mouse    54 LLLSEGRDI----APSNHYSLQRYPGIFNS----------TTSDAFLQSKMRNIFSGRLTAVELV 104

  Fly   138 -IIEQFFHEAFLMFG----------KRFNCPVVTIGTM-GYADNIDHAMGIL------------- 177
             |::.:.....:|.|          ::|:..:|....| |:.  |.|.:|:.
Mouse   105 DILDHYTKNCDMMVGNQALIQGLKKEKFDLLLVDPNDMCGFV--IAHLLGVKYAVFSTGLWYPAE 167

  Fly   178 ----TPWSLIPHLLLSHTDRMTFGQRAYNAYLSLYDAVMRRWVYLPKMQKLAEKYFQGSIEGPLP 238
                .|.:.:|......||||.|.:|..|..:.|...:...::.|||.:::.:||      ..||
Mouse   168 VGAPAPLAYVPEFNSLLTDRMNFLERMKNTGVYLISRIGVSFLVLPKYERIMQKY------NLLP 226

  Fly   239 --NVLDLERNISLVLINAHRSIDLPRPSMPGLIDVGGAHIQKPKQLPTDLQNFLDNA-TYGVIYF 300
              ::.||....||.::....:::.|||::|.::.|||...:....||.|||.::..| .:|.:..
Mouse   227 AKSMYDLVHGSSLWMLCTDVALEFPRPTLPNVVYVGGILTKPASPLPEDLQRWVSGAQEHGFVLV 291

  Fly   301 SMGSYVK--STDLPQEKTALILKAFGQLKQQVIWKFENDSIGDLPSNVMIKKWMPQNDILAHPNV 363
            |.|:.||  |.|:..:    :..|.|:|.|:|||:|......:|.:|..:.:|:||||:|.|.|:
Mouse   292 SFGAGVKYLSEDIANK----LAGALGRLPQKVIWRFSGTKPKNLGNNTKLIEWLPQNDLLGHSNI 352

  Fly   364 KLFITHGGIFGTQEGIYWGVPMLCVPLYGDQHRNTIKSVR-EGYARSLVFSKLTTDDLVRNIETL 427
            :.|::|||:....|.:|.|||::.:||:|| |.:|:..|: :|....|.::.:|..:|...:..:
Mouse   353 RAFLSHGGLNSIFETMYHGVPVVGIPLFGD-HYDTMTRVQAKGMGILLEWNTVTEGELYDALVKV 416

  Fly   428 INDPQYKRSALEVSQRFRDNPIHPLDEATFWIEYIIRHRGARHLKSHGAFIPLHQYLLLDVLGCL 492
            ||:|.|::.|.::|:..:|.|.||::..|:||:||:||.|||||:|....|...||.|||:...|
Mouse   417 INNPSYRQRAQKLSEIHKDQPGHPVNRTTYWIDYILRHDGARHLRSAVHQISFCQYFLLDIAFVL 481

  Fly   493 LLGA----FLAIWLPWRMIRRVHKWWLKGESS-------NKLNEGK 527
            ||||    |:..::...:.|::...|.|.|.|       |.:..||
Mouse   482 LLGAVLLYFILSYVTKFIYRKIKSLWSKNEHSTVNGHYQNGIRNGK 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt301D1	NP_001246079.1	egt	12..483	CDD:223071	139/507 (27%)
Ugt301D1	NP_001246079.1	UDPGT	37..483	CDD:278624	135/481 (28%)
Ugt8a	NP_035804.2	UDPGT	21..502	CDD:278624	148/523 (28%)
Ugt8a	NP_035804.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	518..541		3/10 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	259	1.000	Domainoid score	I1975
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	272	1.000	Inparanoid score	I2975
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm42461
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.860