DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt301D1 and ugt-16

DIOPT Version :9

Sequence 1:	NP_001246079.1	Gene:	Ugt301D1 / 35105	FlyBaseID:	FBgn0032684	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_506210.1	Gene:	ugt-16 / 191171	WormBaseID:	WBGene00013901	Length:	534	Species:	Caenorhabditis elegans

Alignment Length:	556	Identity:	146/556 - (26%)
Similarity:	233/556 - (41%)	Gaps:	91/556 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 MLIFLIGLLEFGAGSRILFMGPFPAPSHWLWLEHFQNDLLRQGHHVTS------------VNNHP 63
            :.:||| |:|.....::|...|....||..:|....:.|:..|:.||.            |.:..
Worm     5 IFLFLI-LVELCFSYKVLVFNPAFGASHANFLGKISDILIDAGNDVTMLIPIFVNGKKELVGSKK 68

  Fly    64 TK--------------HPHENLTEIIISPSFDIPKHFPKENIFSMQ--------FVSDFNNLELW 106
            .|              |...:..||:            ::.|:.|.        |:.:|:....:
Worm    69 VKKIIRIDQDPRIAQIHKEGSTEEIM------------RKTIWKMDSAITSMFGFIGNFSKTAAY 121

  Fly   107 WTIGLMTTEHAFKDPKVKKLIES-KDDHYDLVIIEQFFHEAFLMFGKRFNCPVVTIGTMGYADNI 170
                  .||:.|:.   .:|||. :.:.:||.|.|..|..||.:|.:.....|:...:..|...:
Worm   122 ------QTEYMFQQ---TELIEQLRKEKFDLAITESLFLGAFALFDEIGIRSVINADSTLYMGGM 177

  Fly   171 DHAMGILTPWSLIPHLLLSHTDRMTFGQRAYNA--YL-SLYDAVMR---RWVYLPKMQKLAEKYF 229
            ..|:|.....|..|.|..|..|:|.|..|..||  || .|:.:|::   ..|..||..|.:..:.
Worm   178 KGALGEPAAISYYPGLFSSIDDKMNFFGRVKNAVGYLFGLWFSVLKYDDEIVAFPKSYKGSRDWR 242

  Fly   230 QGSIEGPLPNVLDLERNISLVLINAHRSIDLPRPSMPGLIDVGGAHIQKPKQ----LPTDLQNFL 290
            :..            .|::...||:::.||...|::|..:.|||..:...|.    |..:..:.|
Worm   243 EHL------------SNVAFNFINSNQYIDYASPTLPKTVFVGGMQVNTKKSGKSTLSKEWNDVL 295

  Fly   291 DNATYGVIYFSMGSYVKSTDLPQEKTALILKAFGQLKQQV-IWKFE--NDSIGDLPSNVMIKKWM 352
            ......|: .|.||...|:|:|.|.....|:.|..:.:.. |||:|  |.::.|...||.:..||
Worm   296 SLRKTNVL-VSFGSNAYSSDMPDEFKKSFLEVFASMPETTFIWKYEVANATLVDHLPNVKLTTWM 359

  Fly   353 PQNDILAHPNVKLFITHGGIFGTQEGIYWGVPMLCVPLYGDQHRNTIKSVREGYARSLVFSKLTT 417
            |||||||...:.|||||||:..:.|..|.|.|.:.:||..||.||.....|.|.|..|..:.|..
Worm   360 PQNDILADDRLTLFITHGGLGSSVELAYQGKPAVVIPLMADQPRNAHMLTRHGGALQLDKTWLNN 424

  Fly   418 DDLVRN-IETLINDPQYKRSALEVSQRFRDNPIHPLDEATFWIEYIIRHRGARHLKSHGAFIPLH 481
            .:.:|. |:|::||..||.:|..:::...|.|..|.|......::.::......|.|.|..:...
Worm   425 SEKLREAIQTVLNDVSYKHNAERLAKILEDQPHKPKDVVLKHCDFAVQFGPLDTLNSEGRLLNTF 489

  Fly   482 QYLLLD-------VLGCLLLGAFLAIWLPWRMIRRV 510
            ||..:|       :|..:|...:|.|.|.:|.:.|:
Worm   490 QYYSVDIVLAIFVILSVILFVVYLVIKLLFRFLGRL 525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt301D1	NP_001246079.1	egt	12..483	CDD:223071	136/519 (26%)
Ugt301D1	NP_001246079.1	UDPGT	37..483	CDD:278624	129/494 (26%)
ugt-16	NP_506210.1	UDPGT	19..532	CDD:278624	141/541 (26%)
		egt	<246..503	CDD:223071	80/257 (31%)
		HemY_N	483..>531	CDD:284604	11/43 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	161	1.000	Domainoid score	I2438
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	172	1.000	Inparanoid score	I2735
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.860