DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt301D1 and ugt-54

DIOPT Version :9

Sequence 1:	NP_001246079.1	Gene:	Ugt301D1 / 35105	FlyBaseID:	FBgn0032684	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_501996.2	Gene:	ugt-54 / 188885	WormBaseID:	WBGene00012013	Length:	527	Species:	Caenorhabditis elegans

Alignment Length:	555	Identity:	142/555 - (25%)
Similarity:	238/555 - (42%)	Gaps:	111/555 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 MLIFLIGLLEFGAGSRILFMGPFPAPSHWLWLEHFQND----LLRQGHHVTSV-----NNHPTKH 66
            :|.||| |..|.....|||.....|.||    ..|.|.    ||.:||.|..|     .....|.
Worm     4 LLGFLI-LPGFANCLNILFYVSVIAQSH----IPFHNTAIKVLLDRGHTVDLVIAQLNEMVKLKF 63

  Fly    67 PH---ENLTEIIISPSF---------DIPKHFPKENIFSMQFVSDFNNLELWWTIGLMTTEHAFK 119
            |:   :|.|.....|:|         ||   |.::.|...:|:: |:::    |..|..|  ..|
Worm    64 PNGVGKNYTFGYEDPNFYRKNAGHLSDI---FVEKPIPMAEFLT-FDDM----TFNLCET--VVK 118

  Fly   120 DPKVKKLIESKDDHYDLVIIEQFFHEAFLMFGKRFNCPVVTIGTMGYADNIDHAMGILTPWSLIP 184
            ||.:...|  |..:||:.:...:             .|...|        :.||.|:.:..|::|
Worm   119 DPNLLNYI--KQGNYDIGLSSDY-------------DPCANI--------LMHAGGVPSKASMVP 160

  Fly   185 HLLLSHTDRMTFGQRAYNAYL----SLY---------DAVMRRWVYLPK--------MQKLAEKY 228
            ..|        |..:..:|.|    |:|         |:...|..:|.:        ..:|.|||
Worm   161 TPL--------FQPQIVSAGLPSPASVYGTVLYPKGDDSFFNRLFHLIRHTYNIYFVAPRLMEKY 217

  Fly   229 FQGSIE--GP-LPNVLDLERNISLVLINAHRSIDLPRPSMPGLIDVGGAHIQKPKQLPTDLQNFL 290
            ....:|  || .|:..::|||:.::|:|::..|:.|||....:..:||...:|.:.|..:..:.|
Worm   218 NNLLLETFGPTFPSAEEIERNVDIILVNSNEIIEKPRPVSHKIKYIGGMGKKKAQPLNKEFNDIL 282

  Fly   291 DNATYGVIYFSMGSYVKSTDLPQEKTALILKAFGQLKQ-QVIWKFEN---------DSIGDLPSN 345
            ..:..||:.||.|:.|.::.:|.|.....:.||..... ..:||::|         ||     ||
Worm   283 ATSNKGVVLFSFGTQVATSKVPIEIRKNFVTAFKHFPDFSFLWKYDNLTDDAELFADS-----SN 342

  Fly   346 VMIKKWMPQNDILAHPNVKLFITHGGIFGTQEGIYWGVPMLCVPLYGDQHRNTIKSVREGYARSL 410
            :...:|:||.|:|....||.||:|.|:....|....|:|:|.|||:.||..|.:.:|.......:
Worm   343 IHRVEWLPQTDLLGDNRVKAFISHMGLNSFLETSAAGIPVLAVPLFIDQQHNALNAVSRDIGVIV 407

  Fly   411 VFSKLTTDDLVRNIETLINDPQYKRSALEVSQRFRDNPIHPLDEATF--WIEYIIRHRGARHLKS 473
            ...:||.::||..::.|:.:|:|..:|..:|:...:.|  ...|..|  |:||..::.|...:.:
Worm   408 ERHQLTVENLVNALQKLLYNPKYGENAKMISKMMNEKP--EQSERLFVDWVEYAAKNPGLHKIMN 470

  Fly   474 -HGAFIPLHQYLLLDVLGCLLLGAFLAIWLPWRMI 507
             .||.:....|..:||:..::|....::.:.|:.:
Worm   471 LPGAELTPFWYYSVDVILIVVLSLTSSLIIIWKTL 505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt301D1	NP_001246079.1	egt	12..483	CDD:223071	137/528 (26%)
Ugt301D1	NP_001246079.1	UDPGT	37..483	CDD:278624	127/503 (25%)
ugt-54	NP_501996.2	UDPGT	35..507	CDD:278624	129/519 (25%)
ugt-54	NP_501996.2	egt	<218..498	CDD:223071	79/286 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.810