DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt301D1 and ugt-19

DIOPT Version :9

Sequence 1:	NP_001246079.1	Gene:	Ugt301D1 / 35105	FlyBaseID:	FBgn0032684	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_500912.2	Gene:	ugt-19 / 187129	WormBaseID:	WBGene00019515	Length:	532	Species:	Caenorhabditis elegans

Alignment Length:	555	Identity:	142/555 - (25%)
Similarity:	244/555 - (43%)	Gaps:	67/555 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 MLIFLIGLLEFGAGSRILFMGPFPAPSHWLWLEHFQNDLLRQGHHVT---SVNNHPTKHPHENLT 72
            :|||...:. |.:..:|||.......||..:|....:.|...||:||   .|.:...|...::..
Worm     7 ILIFAATIC-FASSYKILFYTNLFGHSHVKFLGAAADILTDAGHNVTVVMPVFDDSIKTSLKSTK 70

  Fly    73 EIIISPSFDIPKHFPK------ENIFSMQFVSDFNNLELWWTIGLMTTEHAFKDPKV---KKLIE 128
            .||...|.|....|.|      .|:::|...:.|..|.   .:|:|:...:.:..||   .:|||
Worm    71 NIIFVNSSDDVAAFAKARTKMLNNLWTMDNTNPFTMLT---RVGMMSNTFSSQCKKVLTNTELIE 132

  Fly   129 S-KDDHYDLVIIEQF------FHEAFLMFGKRFNCPVVTIGTMGYADNIDHAMGILTPWSLIPHL 186
            : |.::|||.:.|.|      |.||..:   |.:..:::...:   |::...:|.....|..|.|
Worm   133 TMKAENYDLAVTEPFDLCAYPFFEAINI---RAHVGILSSSRL---DHVSDVIGQPAAPSYNPGL 191

  Fly   187 LLSHTDRMTFGQRAYNAYLSLYDAVMRRWVYLPKMQKLAEKYFQGSIEGPLPNVL---------- 241
            :.:::||||..||..|.                 :|.....||...|......|:
Worm   192 MSTNSDRMTMWQRFVNV-----------------IQYACGSYFFSYIGDREAEVVKEINPKWRSW 239

  Fly   242 -DLERNISLVLINAHRSIDLPRPSMPGLIDVGGAHIQKPK---QLPTDLQNFLDNATYGVIYFSM 302
             ::....|.::.|....:|.|.|:...:|.:||..::..|   :|.......||.....| :.|.
Worm   240 REVVPEASFIMTNQIPLLDFPAPTFDKIIPIGGLSVKTDKKSLKLEEKWSKILDIRKKNV-FISF 303

  Fly   303 GSYVKSTDLPQEKTALILKAFGQLKQQV-IWKFE--NDSIGDLPSNVMIKKWMPQNDILAHPNVK 364
            ||..:|.|:|.|.....|:....:.... |||:|  ||...:...||.:..|:|||::||...:.
Worm   304 GSNARSVDMPLEYKNTFLQVIKSMPDTTFIWKYEDLNDKFTEGIENVYLGDWLPQNELLADKRLN 368

  Fly   365 LFITHGGIFGTQEGIYWGVPMLCVPLYGDQHRNTIKSVREGYARSLVFSKLTTDDLVRN-IETLI 428
            :|:||||:....|....|.|.:.:||:.||.||.....|.|....|..:.|:...||:: ||.::
Worm   369 VFVTHGGLGSVTELSMMGTPAVMIPLFADQSRNGQMLKRHGGVAVLKKTDLSDAKLVQSTIEEVL 433

  Fly   429 NDPQYKRSALEVSQRFRDNPIHPLDEATFWIEYIIRHRGARHLKSHGAFIPLHQYLLLDVLGCLL 493
            |:|:|::||..|::..|:.|.:|.:....::|:..|......:.::|..:...||..||::..:.
Worm   434 NNPEYRKSAERVAEMLRNQPTNPKETFLKYVEFTARFGKLPSMDNYGRQLTFVQYFFLDIISIIS 498

  Fly   494 LGAFLAIWLPWRMIRRVHKWWLKGESSNKLNEGKK 528
            |...:.:::.:::||...|......||.:  :.||
Worm   499 LITVVFLYISYKVIRCTIKKCFGSRSSEE--KSKK 531

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt301D1	NP_001246079.1	egt	12..483	CDD:223071	130/507 (26%)
Ugt301D1	NP_001246079.1	UDPGT	37..483	CDD:278624	123/482 (26%)
ugt-19	NP_500912.2	egt	1..472	CDD:223071	129/492 (26%)
ugt-19	NP_500912.2	UDPGT	32..521	CDD:278624	131/515 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	161	1.000	Domainoid score	I2438
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	172	1.000	Inparanoid score	I2735
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.860