DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt301D1 and ugt-32

DIOPT Version :9

Sequence 1:	NP_001246079.1	Gene:	Ugt301D1 / 35105	FlyBaseID:	FBgn0032684	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_504060.2	Gene:	ugt-32 / 185911	WormBaseID:	WBGene00018543	Length:	527	Species:	Caenorhabditis elegans

Alignment Length:	541	Identity:	128/541 - (23%)
Similarity:	216/541 - (39%)	Gaps:	102/541 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 MQLQWKCWMLIFLIGLLEFGAGSRILFMGPFPAPSHWLWLEHFQNDLLRQGHHVTSVNNHPTKHP 67
            |.|.:|   |:.|..:.......|:|...|..|.||..::....:.|...||:||
Worm     1 MALLFK---LMILYSVFSNTDSLRVLVYSPAYAASHTNFMARLADTLTEAGHNVT---------- 52

  Fly    68 HENLTEIIISPSFDIPKHFPKENIFSMQFVSDF-----------------NNLELWWTI------ 109
                   ..:|..|    ..:::.|.::...|.                 |:::.:||.
Worm    53 -------FFTPIID----ESRKDQFGVKLTKDVLILEQDEQVKRNPVTIDNDMKYFWTTDVTSAN 106

  Fly   110 -----------GLMTTEHAFKDPKVKKLIESKDDHYDLVIIEQFFHEAFLMFGKRFNCPVVTIGT 163
                       .:.|.|:.||..::  :.|.:..:||:.:.|........:| :......|.:.|
Worm   107 GHKVMGTLHKQAIFTCENVFKHQEL--IDELRSRNYDIGLAEPLMTCGLALF-RHIGIEKVMLTT 168

  Fly   164 MGYADNIDHAMGILTP-------WSLIPHLLLSHTDRMTFGQRAYNAYLSLYDAVMRRWVYLPKM 221
            .  ..|.|    ||.|       .|..|.:....||.|:|.||..|     ||..   .|.:|..
Worm   169 S--CTNYD----ILLPATGEPEDTSYNPSMNSQVTDVMSFWQRLEN-----YDLY---HVMIPTF 219

  Fly   222 QKLAE-------KYFQGSIEGPLPNVLDLERNISLVLINAHRSIDLPRPSMPGLIDVGG--AHIQ 277
            :.:.:       ||...|    .|:..||..:.||...|:...:|.||||:...|::||  ..|:
Worm   220 ETIFDDEANVYRKYLGES----FPDWRDLIPDASLHFTNSIPFLDFPRPSIQKTIEIGGIAVDIE 280

  Fly   278 KPKQLPTDLQNFLDNATYGVIYFSMGSYVKSTDLPQEKTALILKAF-GQLKQQVIWKFENDSI-- 339
            ....:..:..|.||.....:: .|.||..:||::|......:|:.| .:.....|||:|:|.:
Worm   281 SIPPVNEEFSNILDKRPMNML-ISFGSLARSTEMPIIFKENLLRVFQSEPNCTFIWKYESDDVAF 344

  Fly   340 -GDLPSNVMIKKWMPQNDILAHPNVKLFITHGGIFGTQEGIYWGVPMLCVPLYGDQHRNTIKSVR 403
             .|: .||:..|||||..||....:..|:||||:..|.|..:.|.|.:..|::.||.||:....|
Worm   345 ANDV-ENVIFVKWMPQTAILKDNRLTAFLTHGGLGSTNEAAFLGKPSVMFPIFADQSRNSNMLGR 408

  Fly   404 EGYARSLVFSKLTTDDLVRN-IETLINDPQYKRSALEVSQRFRDNPIHPLDEATFWIEYIIRHRG 467
            :..:..|..|.|.....:|: ...::::.:|..:|.:|:...|:.|..|.|.....:|::.|...
Worm   409 QEMSIVLHKSDLGNFQKIRDAFHEILHNEKYHLNARKVADMVRNQPAKPRDIFVKHVEFVGRFGP 473

  Fly   468 ARHLKSHGAFIPLHQYLLLDV 488
            ..|:..:...:|.:|....|:
Worm   474 LHHMTPYSLKMPFYQRYHYDI 494

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt301D1	NP_001246079.1	egt	12..483	CDD:223071	123/525 (23%)
Ugt301D1	NP_001246079.1	UDPGT	37..483	CDD:278624	117/500 (23%)
ugt-32	NP_504060.2	Glycosyltransferase_GTB_type	1..508	CDD:299143	128/541 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	172	1.000	Inparanoid score	I2735
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.860