DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt301D1 and ugt-43

DIOPT Version :9

Sequence 1:	NP_001246079.1	Gene:	Ugt301D1 / 35105	FlyBaseID:	FBgn0032684	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_001255487.1	Gene:	ugt-43 / 184052	WormBaseID:	WBGene00008485	Length:	540	Species:	Caenorhabditis elegans

Alignment Length:	555	Identity:	132/555 - (23%)
Similarity:	224/555 - (40%)	Gaps:	98/555 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 CWMLIFLIGLLEFGA-----GSRILFMGPFPAPSHWLWLEHFQNDLLRQGHHVTSVNNHPTKHPH 68
            |..|:.::....|..     |.::|...|....||..::....|.|..:|::||
Worm     6 CSFLLLILASFCFSVSNNIKGKKVLVYLPVTGHSHLKFMSTTSNILQEEGYNVT----------- 59

  Fly    69 ENLTEIIISPSFDIPKHFPKENIFSMQFVSDFNNLEL-------------------WWTIG---- 110
                  ::.|..||..:  ..||..::.:....||::                   .||:|
Worm    60 ------LLLPLIDITLN--NTNIPIVKKIKHRINLDIHPGVMRTIIKMGGMASRRQTWTMGSGIY 116

  Fly   111 -------LMT------TEHAFKDPKVKKLIESKDDHYDLVIIEQFFHEAFLMFGKRFNCPVVT-- 160
                   |::      .::.|..|.:  |...|.:.|::.:.|.||...|.:|.......:::
Worm   117 GFDGISHLLSDLYSNICDNIFHMPGL--LDRLKAEKYEMGMSEPFFVCGFALFDHLGIDKIISVD 179

  Fly   161 --IGTMGYADNIDHAMGILTPWSLIPHLLLSHTDRMTFGQRAYNAYLSLYDAVMRRWVYLPKMQK 223
              ||..|  ..|.|...:.:  |.:|......:|.|:|.:|.    .|||:..:.|     |..:
Worm   180 SHIGLEG--PKIAHGFPVTS--SYLPAAFSESSDHMSFVERT----RSLYETYLNR-----KFAR 231

  Fly   224 LAEKYFQGSIEGPLPNVL---DLERNISLVLINAHRSIDLPRPSMPGLIDVGGAHIQKPKQ---L 282
            |.......:::|......   :|.|..:.:..|::..:|.|.|.....|::||....:.|.   |
Worm   232 LIHNKEIDAMKGVYKGKSTWEELMRLPAYMFTNSNPILDFPYPRPSKFIEIGGIAADEKKHDEVL 296

  Fly   283 PTDLQNFLDNATYGVIYFSMGSYVKSTDLPQEKTALILKAFGQLKQ-QVIWKFENDSIGDLP--- 343
            |....:.| |.....:..|.||..||..:|......::.|.|.:.. ..|||:||.||..:.
Worm   297 PESYDHIL-NLRNRTVLISFGSNAKSIFMPDHMRRSLIIALGMMPDITFIWKYENSSIDIVKEFD 360

  Fly   344 ---SNVMIKKWMPQNDILAHPNVKLFITHGGIFGTQEGIYWGVPMLCVPLYGDQHRNTIKSVREG 405
               .|::...||||..:||.|.:.||:||||:..|.|..:.|.|.:.||::|||.||:....|.|
Worm   361 PTIKNIVQVDWMPQQALLADPRLDLFVTHGGMASTNEIAFSGKPAVMVPVFGDQTRNSRMLERHG 425

  Fly   406 YARSLVFSKLTTDDLVRNIETL---INDPQYKRSALEVSQRFRDNPIHPLDEATFWIEYIIRHRG 467
            ....|....|...::|  |||:   :|||.|...|.:::...|::|..|......:..::.|...
Worm   426 GVLMLRKENLEYPEIV--IETILSVLNDPSYAERAQQLATLLRNHPESPKQVFLKYFNFVARFGK 488

  Fly   468 ARHLKSHGAFIPLHQYLLLDVLGCLLLGAFLAIWL 502
            ...:.|:...:....|..||::..||:.|:.|.:|
Worm   489 PTGIDSNSINVDFIAYYYLDLIAFLLIVAYFAKFL 523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt301D1	NP_001246079.1	egt	12..483	CDD:223071	123/531 (23%)
Ugt301D1	NP_001246079.1	UDPGT	37..483	CDD:278624	118/501 (24%)
ugt-43	NP_001255487.1	Glycosyltransferase_GTB_type	<215..517	CDD:299143	85/313 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	161	1.000	Domainoid score	I2438
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	172	1.000	Inparanoid score	I2735
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.860