DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt301D1 and ugt-27

DIOPT Version :9

Sequence 1:	NP_001246079.1	Gene:	Ugt301D1 / 35105	FlyBaseID:	FBgn0032684	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_491436.1	Gene:	ugt-27 / 182508	WormBaseID:	WBGene00015694	Length:	526	Species:	Caenorhabditis elegans

Alignment Length:	546	Identity:	131/546 - (23%)
Similarity:	241/546 - (44%)	Gaps:	74/546 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 FLIGLLEFGAGS-RILFMGPFPAPSHWLWLEHFQNDLLRQGHHVT----SVNNHPTKHPHENLTE 73
            ||..||.|...| .:|...|..|.||..::....:.|...||:||    .|:...||....::|.
Worm     7 FLRFLLIFQVNSINVLVYSPAFAASHTNFMARLADTLTEAGHNVTFLVPIVDVARTKQLGVHVTT 71

  Fly    74 IIISPSFDIPKHFPKENI-FSMQFVSDFNNLELWWT-------IG----------LMTTEHAFKD 120
            .:|....|  :|..:|:: |.       :::|.:||       :|          .:..|:..:.
Worm    72 DVIIVEKD--EHTTQESVPFD-------DSMEAYWTEETHSSNVGESFQWFFDGMKLGCENLLRR 127

  Fly   121 PKVKKLIESKDDHYDLVIIEQFFHEAFLMFGKRFNC-PVVTIGTMGYADNIDHAMGILTPWSLIP 184
            .::  |.:.|..::|:.|:|. .....|...|:... ..:...:..|.|.:...:|.....|.:|
Worm   128 HEI--LDQLKSRNFDVAIVEP-LSVCGLGLAKKLEIGKTILASSCAYYDYLFRHIGEPDVHSYLP 189

  Fly   185 HLLLSHTDRMTFGQRAYN---------AYLSLYDAVMRRWVYLPKMQKLAEKYFQGSIEGPLPNV 240
            .|:.:..|.||..:|..|         |...::|:  .:.:|        .|:|...|    |:.
Worm   190 SLMSTTGDVMTTFERLENHRVAEAMATAMYKMFDS--EKAIY--------RKHFGDEI----PDW 240

  Fly   241 LDLERNISLVLINAHRSIDLPRPSMPGLIDVGGAHIQ----KPKQLPTDLQNFLDNATYGVIYFS 301
            .||....||...|::..:|.|||.:...:.:||..:.    |.::|..:..:.|:.....:: .|
Worm   241 RDLLPAASLYFTNSNPYLDFPRPILQKTVSIGGISVDTKKIKSQELDKEWNHILNKRNLNML-IS 304

  Fly   302 MGSYVKSTDLPQEKTALILKAFGQLKQQ----VIWKFE-ND-SIGDLPSNVMIKKWMPQNDILAH 360
            .||.:.|:.:..:....::|.   :|.:    .|||:| || |......|:...||:||:.:|..
Worm   305 FGSMIHSSHMLDDAKKNLIKV---IKSEPNVTFIWKYETNDTSFAFGIDNIYFSKWVPQSKLLND 366

  Fly   361 PNVKLFITHGGIFGTQEGIYWGVPMLCVPLYGDQHRNTIKSVREGYARSLVFSKLTTDDLVRN-I 424
            ..:..|:||||:..|.|..::|.|.:.||::|||:||.....|.|.|..:..::|:...:|.: :
Worm   367 ARLTAFLTHGGLGSTNELAHFGKPAVMVPIFGDQYRNGHMLQRHGCAIIVQKTELSNWKIVSSAV 431

  Fly   425 ETLINDPQYKRSALEVSQRFRDNPIHPLDEATFWIEYIIRHRGARHLKSHGAFIPLHQYLLLDVL 489
            ::::.|..||::|..::...::.|:.|.:....::|::.|......:.::|..:...|..||||.
Worm   432 KSVLYDENYKKNAAHLADLLQNQPVKPKEIVVKYVEFVARFGPFPEMDAYGRQLNFIQRNLLDVY 496

  Fly   490 GCLLLGAFLAIWLPWRMIRRVHKWWL 515
            ...|.|.||...:.:.:|....|.||
Worm   497 LIELFGHFLFFLIIFCLIPLQLKRWL 522

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt301D1	NP_001246079.1	egt	12..483	CDD:223071	118/512 (23%)
Ugt301D1	NP_001246079.1	UDPGT	37..483	CDD:278624	109/488 (22%)
ugt-27	NP_491436.1	UDPGT	21..500	CDD:278624	117/508 (23%)
ugt-27	NP_491436.1	egt	<230..478	CDD:223071	66/255 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	172	1.000	Inparanoid score	I2735
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.860