DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt301D1 and ugt-1

DIOPT Version :9

Sequence 1:	NP_001246079.1	Gene:	Ugt301D1 / 35105	FlyBaseID:	FBgn0032684	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_505671.1	Gene:	ugt-1 / 179449	WormBaseID:	WBGene00007072	Length:	529	Species:	Caenorhabditis elegans

Alignment Length:	548	Identity:	134/548 - (24%)
Similarity:	231/548 - (42%)	Gaps:	57/548 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 MLIFLIGLLEFGAGSRILFMGPFPAPSHWLWLEHFQNDLLRQGHHVTSVNNHPTKH-----PHEN 70
            :|..|:..|.|......|.:.|....||..::....:.|....|:||.:..:..:|     ..:|
Worm     3 ILFLLLTSLTFCYSHNFLVVSPVFGYSHMKFMNKVADTLANGDHNVTILQTYNYEHFGKIRMAKN 67

  Fly    71 LTEIIISPSFDIPKHFPKEN---IFSMQFVSDFNNLELWWTIGLMTT---------EHAFKDPKV 123
            ....|:....|..|....||   .|...:.::..|..:...|...|.         |....|.|:
Worm    68 TNVEILDYHLDESKAVSNENSASAFKYMWNTEIINNPITGAIATSTVLYGEMKTMCEKVLLDKKL 132

  Fly   124 KKLIESKDDHYDLVIIEQFFHEAF----LMFGKRFNCPVVTIGTMGYADNIDHAMGILTPWSLIP 184
            .|.|.||:       .:.|..|.|    |..|......::.:.:...:....:|:|..:..:.:|
Worm   133 HKWILSKN-------FDGFISEPFDFCGLYLGDHLKLNIIPMHSSTKSLPSVYAIGEPSLLNFLP 190

  Fly   185 HLLLSHTDRMTFGQRAYNAYLSLYDAVMRRWVYLPKMQ----KLAEK-YFQGS--IEGPLPNVLD 242
            .:      |..||...     :::|.: ...:.||.::    ||.|| |.|.|  :.|.:.:..:
Worm   191 SM------RTKFGTEQ-----TVFDRI-GDIIALPCLELAFSKLFEKQYKQASQLLNGDVRHWKE 243

  Fly   243 LERNISLVLINAHRSIDLPRPSMPGLIDVGGAHIQKPKQLPTDLQ-NFLDNATYGVIYFSMGSYV 306
            :.:..:....||:..|..|.||:|..:.:||..|..||.|..:.: |.:.:.....:..|.|:.:
Worm   244 ILQTATFYFSNANDFIAFPTPSLPKHVHIGGFTIDPPKNLKLEEEYNKILSLRKSTVLISFGTVI 308

  Fly   307 KSTDLPQEKTALILKAFGQLKQQV-IWKFENDS---IGDLPSNVMIKKWMPQNDILAHPNVKLFI 367
            :|.|:|:.....|:|.|..|.... |||:|.:.   |..||:|.::|||:||..:||.|.:|||:
Worm   309 QSADMPESFKDGIIKMFHLLPDTTFIWKYEVEDQQFIERLPNNAILKKWVPQPALLADPRLKLFV 373

  Fly   368 THGGIFGTQEGIYWGVPMLCVPLYGDQHRNTIKSVREGYARSLVFSKLTTDD---LVRNIETLIN 429
            ||||:..|.|..|.|.|.|.:|::|||..|.....|.|.|  .||.|...:|   |...|:.:|.
Worm   374 THGGLGSTLEVAYSGKPALMIPVFGDQLLNAKMLSRHGGA--TVFDKYDLEDAEKLTSAIKEIIG 436

  Fly   430 DPQYKRSALEVSQRFRDNPIHPLDEATFWIEYIIRHRGARHLKSHGAFIPLHQYLLLDVLGCLLL 494
            :.::.:.:..::...|:.||.|.......:|:..:......|:.:.......||.:||....:..
Worm   437 NEEFNKKSHHIADLLRNQPIDPKANLLKHVEFSAKFGRVDALEPYNVHYNFVQYYMLDAFAIIFS 501

  Fly   495 GAFLAIWLPWRMIRRVHKWWLKGESSNK 522
            ...:..:|...:.:.|:|...|.:|..:
Worm   502 ILIIIFYLAHLLFKFVYKHVFKTKSKKE 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt301D1	NP_001246079.1	egt	12..483	CDD:223071	125/506 (25%)
Ugt301D1	NP_001246079.1	UDPGT	37..483	CDD:278624	119/481 (25%)
ugt-1	NP_505671.1	UDPGT	28..528	CDD:278624	128/520 (25%)
ugt-1	NP_505671.1	egt	<190..494	CDD:223071	90/317 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.810