DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt301D1 and ugt-17

DIOPT Version :9

Sequence 1:	NP_001246079.1	Gene:	Ugt301D1 / 35105	FlyBaseID:	FBgn0032684	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_001122841.1	Gene:	ugt-17 / 179406	WormBaseID:	WBGene00007422	Length:	540	Species:	Caenorhabditis elegans

Alignment Length:	525	Identity:	128/525 - (24%)
Similarity:	237/525 - (45%)	Gaps:	49/525 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LQWKCWMLIFLIGLLEFGAGSRILFMGPFPAPSHWLWLEHFQNDLLRQGHHVT---SVNNHPTKH 66
            :.::.:::..|..::::....::|...|....||..:|....:.|:..||.||   .:.....||
Worm     1 MNFQYYIIFILFSIIDYSNSYKVLVFNPAFGASHSNFLGKISDILIDAGHDVTMLIPIAMQGKKH 65

  Fly    67 -----PHENLTEIIISP-SFDIPKHFPKENIFSMQFVSDFNNLELWW--------TIGLMTTEHA 117
                 ..:|:..|...| |.::.|....|::...:.....:::.|::        |.|.. .:|.
Worm    66 LVGSKKVKNIIRIDQDPRSIELYKQTGAEDVLRKKIWKVESDIALFFKMAGNFSKTCGYQ-CQHV 129

  Fly   118 FKDPKVKKLIESKDDHYDLVIIEQFFHEAFLMFGKRFNCPVVTIGTMGYADNIDHAMGILTPWSL 182
            |:..::  |.:.|::|::|.|.|..|...:.:|.......::...::.:.|.:...:|..:..:.
Worm   130 FQQTEI--LEKLKNEHFELGITESLFICGYPLFDHLGVKTIINADSVLFMDIVKCTLGEPSSSTF 192

  Fly   183 IPHLLLSHTDRMTFGQRAYNAYLSLYDAVMRRWVYLPKMQ-----KLAEKYFQGSIEGPLPNVLD 242
            .|.|:...||:||..:|..||...|..      ||..||:     .:.|.|:.||     ....:
Worm   193 YPALISPMTDKMTLVERIKNAIQMLIP------VYFSKMRFEEELSMIEPYYNGS-----KTWEE 246

  Fly   243 LERNISLVLINAHRSIDLPRPSMPGLIDVGGAHIQKPKQLPTDLQNFLD---NATYGVIYFSMGS 304
            |..|::..::|::|.:|...|::|..:.:||..::..||....|....|   |.....:..|.||
Worm   247 LLENVAFNMVNSNRYLDYASPTLPKTVFIGGMQVKTKKQGTPKLNKEWDDLLNIRKENVLVSFGS 311

  Fly   305 YVKSTDLPQEKTALILKAFGQLKQ-QVIWKF--ENDSIGDLPSNVMIKKWMPQNDILAHPNVKLF 366
            ...|:::|.|.....|..|..:.: ..|||:  ||.:|....|||.:..||||:|:||...:.||
Worm   312 NAFSSEMPDEFKKSFLDVFASMPEITFIWKYEQENSTIAMHLSNVKMTTWMPQSDLLADNRLSLF 376

  Fly   367 ITHGGIFGTQEGIYWGVPMLC----VPLYGDQHRNTIKSVREGYARSLVFSKLTTDDLVRN-IET 426
            :||||:..:.|..|.|.|.:.    :||..||.||.....|.|.|..|..:.|....::|: |:|
Worm   377 VTHGGLGSSIELAYQGTPAVVNIFKIPLMADQPRNAHMLTRHGGAIQLDKTNLDNPQMIRDAIKT 441

  Fly   427 LINDPQYKRSALEVSQRFRDNPIHPLDEATFWIEYIIRHRGARHLKSHGAFIPLHQYLLLDVL-- 489
            ::::..|..:|.:::|...|.|..|.:......::.::......|:|.|..:.:.|:...|:|
Worm   442 ILDNDSYTENARKLAQILEDQPYTPAEVVLKHCDFAVKFGVLDTLQSEGRKLNVFQFYSYDILVV 506

  Fly   490 GCLLL 494
            .|.|:
Worm   507 VCFLI 511

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt301D1	NP_001246079.1	egt	12..483	CDD:223071	123/503 (24%)
Ugt301D1	NP_001246079.1	UDPGT	37..483	CDD:278624	120/478 (25%)
ugt-17	NP_001122841.1	egt	1..513	CDD:223071	128/525 (24%)
ugt-17	NP_001122841.1	UDPGT	22..538	CDD:278624	127/504 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	161	1.000	Domainoid score	I2438
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	172	1.000	Inparanoid score	I2735
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.860