DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt301D1 and ugt-53

DIOPT Version :9

Sequence 1:	NP_001246079.1	Gene:	Ugt301D1 / 35105	FlyBaseID:	FBgn0032684	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_503771.1	Gene:	ugt-53 / 178744	WormBaseID:	WBGene00020182	Length:	515	Species:	Caenorhabditis elegans

Alignment Length:	542	Identity:	144/542 - (26%)
Similarity:	227/542 - (41%)	Gaps:	75/542 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 MLIFLIGLLEFGAGSRILFMGPFPAPSHWLWLEHFQNDLLRQGHHVTSV----NNHPTKHPHENL 71
            :||||..|:.|.:...|||......|||..:|.:....||.:||:|..|    |.........::
Worm     3 LLIFLTVLINFSSCLNILFYYAVIGPSHIAYLRNTIGKLLARGHNVDVVFAVYNELANLDLFPDV 67

  Fly    72 TEIIISPSFDIPKHFPKE-NIFSMQF---VSDFNNLELWWTIGLMTTEHAFKDPKVKKLIESKDD 132
            ..|..:...| |.::.|. |.||..|   .:.....|::...|....:.|..|   .||||
Worm    68 RRIYYNRHAD-PDYWKKNANHFSNMFEKSPTPLGEFEIFHESGYQLCKIAIND---LKLIE---- 124

  Fly   133 HYDLVIIEQFFHEAFLMFGKRFNCPVVTIGTMGYADNID-------HAMGILTPWSLI------P 184
                          ||..||.         .:|::.:.|       .|.||.:..|||      |
Worm   125 --------------FLKSGKY---------DIGFSSDYDPCGNILMTAAGIPSIGSLIATPIFLP 166

  Fly   185 HLLLS--HTDRMTFGQRAYNAY-LSLYDAVMR--RWVYL-----PKMQKLAEKYFQGSIEGPLPN 239
            |::.:  .|....:|...|..: .||||.:..  |..|.     |.|.:..............|:
Worm   167 HIVSAGLPTVASVYGTSLYPEHDSSLYDKIFNLIRLTYYHYAISPDMDRKYNNLITKRFGNNFPD 231

  Fly   240 VLDLERNISLVLINAHRSIDLPRPSMPGLIDVGGAHIQKPKQLPTDLQNFLDNATYGVIYFSMGS 304
            |..:||.|.::.:|:|..::..||..|.:..:||..|:|.||||.:.:..|.......:.||.|:
Worm   232 VGTIERGIDIIFVNSHDFLEQQRPMSPKIKYIGGMAIRKAKQLPDEFEKILSVPKSAYVLFSFGT 296

  Fly   305 YVKSTDLPQEKTALILKAFGQLKQ-QVIWKFENDSI-GDL---PSNVMIKKWMPQNDILAHPNVK 364
            .|.:..:|.......:.||.:... ..:||:::..: .|:   ..|:...:|:||.::|....||
Worm   297 QVPTAKMPLPIRRNFVGAFKKFPNVTFLWKYDSLELDADIFQGVENIHRLEWLPQTELLHDNRVK 361

  Fly   365 LFITHGGIFGTQEGIYWGVPMLCVPLYGDQHRNTIKSVREGYARSLVFSKLTTDDLVRNIETLIN 429
            |||:|.|:....|....|||:|.:||:.||..|...:...|....|...||||.::...:..|:.
Worm   362 LFISHMGLNSYLETATAGVPVLSIPLFADQQNNAQNTRDRGMGLLLDRDKLTTKNIESALHELLE 426

  Fly   430 DPQYKRSALEVSQRFRDNPIHPLDEATFWIEYIIRHRG-ARHLKSHGAFI-PLHQY------LLL 486
            :|:|..:|..:|:...:.|....|....|:|:..|:.| .|.||..||.: |.:.|      |:.
Worm   427 NPKYLSNARSISKMILEKPDKANDTFIHWLEFTARNPGLGRVLKLPGAELSPFYYYCGDILLLVF 491

  Fly   487 DVLGCLLLGAFLAIWLPWRMIR 508
            .:|..:|......|.||.|.|:
Worm   492 CILFIILHTVLRTINLPSRKIK 513

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt301D1	NP_001246079.1	egt	12..483	CDD:223071	135/508 (27%)
Ugt301D1	NP_001246079.1	UDPGT	37..483	CDD:278624	125/483 (26%)
ugt-53	NP_503771.1	UDPGT	29..497	CDD:330975	128/498 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm14449
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.710