DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt301D1 and ugt-29

DIOPT Version :9

Sequence 1:	NP_001246079.1	Gene:	Ugt301D1 / 35105	FlyBaseID:	FBgn0032684	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_001370778.1	Gene:	ugt-29 / 178581	WormBaseID:	WBGene00021709	Length:	536	Species:	Caenorhabditis elegans

Alignment Length:	565	Identity:	133/565 - (23%)
Similarity:	234/565 - (41%)	Gaps:	99/565 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 MLIFLIGLLEFGAGS--RILFMGPFPAPSHWLWLEHFQNDLLRQGHHVTSVNNHPTKHPHE---- 69
            :|..||..|.|.:.|  .||...|..|.||..:|....:.|..:||:||.:  .|...|.:
Worm     2 LLNSLIFTLLFCSSSSLNILVYSPAYAASHSNFLGKLADTLTERGHNVTYL--MPVMDPGKRDEC 64

  Fly    70 ---NLTEIIISPSFDIPKHFPKENIFSMQ--FVSDFNNLELWWTIGLMTT---------EHAFKD 120
               .||:.::....|       |.:.|.:  ...|...:||:|...:.::         .:|.|.
Worm    65 IGVKLTKDLVIVEAD-------EEMMSREEGVTLDEEIMELYWKSEMDSSNSRDMFSFFNNAMKA 122

  Fly   121 P-----KVKKLIES-KDDHYDLVIIEQFFHEAFLMFGKRFNC-PVVTIGTMGYADNIDHAMGILT 178
            .     |.:.:.|. |..::|:.|:|. .....|.|.|.... ..:...:..:.|:|...:|...
Worm   123 ACRNFLKRRDIFEQMKSRNFDVAIVEP-LSVCGLGFVKALGIEKTILASSCTFYDSIMDYIGEPL 186

  Fly   179 PWSLIPHLLLSHTDRMTFGQRAYNAYLSLYDAVMRRWVYLPKMQ-KLAEKY------FQGSIEGP 236
            .:|.:|.|.....|.||..:|..|            |:...::. .:.||:      ::..:...
Worm   187 DFSYVPALFSVTGDVMTMSERYEN------------WMVTKEINIGIHEKFDDEMKSYREFLGQD 239

  Fly   237 LPNVLDLERNISLVLINAHRSIDLPRPSMPGLIDVGGAHIQ----KPKQLPTDLQNFLDNATYGV 297
            ||:..:|....|:..||::...|.|||.:...:.:||..:.    |.::|..|.:..|:.....|
Worm   240 LPDWRELLSTASIFFINSNPFFDFPRPVLQKTVPIGGISVNLKWIKEQKLTKDWEEVLEMRKKTV 304

  Fly   298 IYFSMGSYVKSTDLPQE-KTAL--ILKAFGQLKQQVIWKFEND--SIGDLPSNVMIKKWMPQNDI 357
            : .|.||.|||..:|:: :..|  ::|:...:  ..|||:|.|  |..|..||:...||:||..:
Worm   305 L-ISFGSLVKSAYMPKKWRNGLLDVIKSMPDV--TFIWKYETDDVSFADGVSNIHFSKWVPQTAL 366

  Fly   358 LAHPNVKLFITHGGIFGTQEGIYWGVPMLCVPLYGDQ----------------HRNTIKSVREGY 406
            |..|.:.:|:||||:..|.|..|.|.|.:.:|::.||                |:|::::|:
Worm   367 LNDPRLSVFVTHGGLGSTMELAYSGKPAVVIPVFADQIRNANMIARHRGVIYLHKNSMENVK--- 428

  Fly   407 ARSLVFSKLTTDDLVRNIETLINDPQYKRSALEVSQRFRDNPIHPLDEATFWIEYIIRHRGARHL 471
                |..|..||        ::.|..|:::|.:::....:.|..|.:....:.|::..|....::
Worm   429 ----VTRKAFTD--------VLFDDSYQKNAEKLANILMNQPYSPKENVIKYTEFLGEHGPFPNM 481

  Fly   472 KSHGAFIPLHQYLLLDVLGCLLLGAFLAIWLPWRMIRRVHKWWLK 516
            ..||..:...|...||:.....|.......:....||.|:|:..|
Worm   482 DPHGRHLNYFQKTFLDIYTLFALFYIFVSTIIIVTIRFVYKFTRK 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt301D1	NP_001246079.1	egt	12..483	CDD:223071	124/529 (23%)
Ugt301D1	NP_001246079.1	UDPGT	37..483	CDD:278624	114/502 (23%)
ugt-29	NP_001370778.1	GT1_Gtf-like	18..468	CDD:340817	114/489 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	172	1.000	Inparanoid score	I2735
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.860