DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt301D1 and ugt-45

DIOPT Version :9

Sequence 1:	NP_001246079.1	Gene:	Ugt301D1 / 35105	FlyBaseID:	FBgn0032684	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_500410.2	Gene:	ugt-45 / 177139	WormBaseID:	WBGene00021372	Length:	527	Species:	Caenorhabditis elegans

Alignment Length:	531	Identity:	131/531 - (24%)
Similarity:	229/531 - (43%)	Gaps:	51/531 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 MLIFLIGLLEFGAGS--RILFMGPFPAPSHWLWLEHFQNDLLRQGHHVTSVN--NHPTKHPHENL 71
            :|:||: |....|.|  :||...|....||...:....:.|:..||.||.:.  :.|.......|
Worm     3 VLVFLL-LFVLPAASCYKILVSVPKFGFSHMQTMGKLADILVEAGHDVTFLMPVDVPIPQNGTEL 66

  Fly    72 TEIIISPSFD----IPKHFPKENIFSMQFVSDFNNLE--LWWT--IGLMTTEHAFKDPKVKKLIE 128
            .::::.|:.|    |..|..|....:..:....|:.:  :|.|  ||.::..:      .|.||:
Worm    67 AKVVLVPTTDAINEIMGHAMKSGAVANLWTHSANSKQGIMWSTDMIGQVSYHN------TKNLID 125

  Fly   129 S-------KDDHYDLVIIEQFFHEAFLMFGKRFNCPVVTI-GTMG-YADNIDHAMGILTPWSLIP 184
            :       ||:.:|:.|.|.|.......|      .|:.: ..|| :..::.....:.|...::|
Worm   126 NKALVQQMKDEKFDIGITELFDFSGLAFF------EVIGLKNVMGAHTTSVFEGTLMATGAPILP 184

  Fly   185 HLLLSHTDRMTFGQRAYNAYLSLYDAVMRRWVY--LPKMQKLAEKYFQGSIE-GPLPNVLDLERN 246
            ..:.:   ..||...:.:....|.:..|..|.|  ..|:|..|:|......| |..|.:.:|..:
Worm   185 SFVPA---SQTFTDDSGSILSRLNNLYMTYWSYQFQNKIQSFAQKALDEHYEKGKAPKIWNLVSD 246

  Fly   247 ISLVLINAHRSIDLPRPSMPGLIDVGGAHIQKPKQLPTDLQNFLDNATYGVIYFSMGSYVKSTDL 311
            |:...:|:....|.|:|....::::.|..:.:.|.:..:....|...:..|: .|.||....|.:
Worm   247 ITWFFVNSDPIFDFPKPLPQNIVEIAGISVPEIKPVGKEWDEILSKRSKNVL-VSFGSIASPTTM 310

  Fly   312 PQEKTALILKAFGQLKQ-QVIWKFENDSIGDLPS---NVMIKKWMPQNDILAHPNVKLFITHGGI 372
            |:.....|:.||..... ..|||:: |:...|.:   ||.|.|||||||:||...:.:|.||||:
Worm   311 PEAVKKSIVDAFAAFPDVTFIWKYD-DTESKLTAHLDNVHIVKWMPQNDLLADKRISMFWTHGGM 374

  Fly   373 FGTQEGIYWGVPMLCVPLYGDQHRNTIKSVREGYARSLVFSKL---TTDDLVRNIETLINDPQYK 434
            ....|.....||::.||::|||.||...:.|.|.|  |::.|:   .|..|:..::.::.:|:||
Worm   375 GSLMESAQKSVPLVVVPIFGDQMRNAQIAKRHGVA--LIYDKMDLSNTKKLIGALKEVLENPEYK 437

  Fly   435 RSALEVSQRFRDNPIHPLDEATFWIEYIIRHRGARHLKSHGAFIPLHQYLLLDVLGCLLLGAFLA 499
            :||..:::........|..:....:|...|........|.|......:|..||::...:...||:
Worm   438 KSAELLARILATERFSPRQKIIDTVEMAGRFGQMPRWTSAGKEFSFLKYFNLDLVIIAVFIFFLS 502

  Fly   500 IWLPWRMIRRV 510
            |.....:||.:
Worm   503 IVSTVLLIRHL 513

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt301D1	NP_001246079.1	egt	12..483	CDD:223071	123/501 (25%)
Ugt301D1	NP_001246079.1	UDPGT	37..483	CDD:278624	114/474 (24%)
ugt-45	NP_500410.2	egt	14..513	CDD:223071	127/517 (25%)
ugt-45	NP_500410.2	UDPGT	19..510	CDD:278624	123/509 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	161	1.000	Domainoid score	I2438
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	172	1.000	Inparanoid score	I2735
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm14613
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.860