DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt301D1 and ugt-25

DIOPT Version :9

Sequence 1:	NP_001246079.1	Gene:	Ugt301D1 / 35105	FlyBaseID:	FBgn0032684	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_491438.1	Gene:	ugt-25 / 172087	WormBaseID:	WBGene00015692	Length:	531	Species:	Caenorhabditis elegans

Alignment Length:	567	Identity:	125/567 - (22%)
Similarity:	236/567 - (41%)	Gaps:	107/567 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 WMLIFLIGLLEFGAGSRILFMGPFPAPSHWLWLEHFQNDLLRQGHHVTSV------------NNH 62
            ::|:.:|.:..|    .||...|....||..::....:.|...||:||.|            ...
Worm     7 FILLSVINVNAF----NILVYSPSFGGSHTNFMARLADTLTEAGHNVTFVVPVADEARKGQLGVK 67

  Fly    63 PTKH----PHENLTEIIISPSFDIPKHFPKENIFSMQFVSDFNNLELWWTIGLMTTEHAFKDPKV 123
            .||.    ..:.|.:..|.|..|....:.:.::.|....|.|:   ::....|::..:..::.||
Worm    68 KTKDVVIVEQDELMKSEIKPLDDDMAQYWETDMDSSNADSIFS---VFSDAMLLSCNNFMRNKKV 129

  Fly   124 KKLIESKDDHYDLVIIEQFFHEAFLMFGKRFNCPVVTIGTMGYADNIDHAMGI------------ 176
              ..|.|..::|:.|.|                |:...| :||.    ||:||
Worm   130 --FNELKSRNFDVGIYE----------------PLSVCG-LGYM----HAIGINKLIMSSSCALY 171

  Fly   177 ---------LTPWSLIPHLLLSHTDRMTFGQRAYNAYLSLYDAVMR--RWVYLPKMQKLAEKYFQ 230
                     ...:|.:|..:....::|:..::..|..||:..:.|:  :|   .|..::.:|:..
Worm   172 DGTVAAIGEPIDFSYVPGSMSKSGEKMSLFEKLENYRLSMASSRMQYGQW---DKETEIYKKHLG 233

  Fly   231 GSIEGPLPNVLDLERNISLVLINAHRSIDLPRPSMPGLIDVGGAHIQ----KPKQLPTDLQNFLD 291
            ..|    |:..||..:.|:...|:...:|.||......:.:||..:.    |.::|..:....||
Worm   234 NDI----PHWRDLMPSSSVAFTNSIPYVDFPRSITQKTVPIGGISVDMEMIKSQKLSIEWSTVLD 294

  Fly   292 NATYGVIYFSMGSYVKSTDLPQEKTALILKAFGQLKQQ----VIWKFENDSI--GDLPSNVMIKK 350
            ...:.:: .|.||.|:|.|:|.:....:|:|   :|.:    .|||:|||::  .....|:...|
Worm   295 ERPHNML-ISFGSMVRSMDMPLKWRNGLLEA---IKSEPNVTFIWKYENDNLEWAKGIQNIYFSK 355

  Fly   351 WMPQNDILAHPNVKLFITHGGIFGTQEGIYWGVPMLCVPLYGDQHRNTIKSVREGYARSLVFSKL 415
            |:||..:|....:..|:||||:..|.|..:.|.|.|.||::.||.||.....|.|..  ||..|.
Worm   356 WVPQTALLNDARLTAFMTHGGLGSTNELAFLGKPALMVPVFADQDRNANMLARHGGV--LVVHKK 418

  Fly   416 TTDD---LVRNIETLINDPQYKRSALEVSQRFRDNPIHPLDEATFWIEYIIRHRGARHLKSHGAF 477
            ...:   :..:|.:::::.:|:::|.::|:...:.|:.|.::...:.|::.:......:.|:|..
Worm   419 ELGNFKTIKSSIRSILHEEKYQKNARKLSELLNNQPLKPKEQVVKYTEFVAKFGPFPQMDSYGRQ 483

  Fly   478 IPLHQYLLLDVLGCLLLGAFLAIWL------------PWRMIRRVHK 512
            :...|..|:|:...:.|.....|.|            |.::::.|.|
Worm   484 LGFIQRNLIDIYAAISLSYLFVISLIYFVFKFVISKTPLKLVKLVKK 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt301D1	NP_001246079.1	egt	12..483	CDD:223071	116/522 (22%)
Ugt301D1	NP_001246079.1	UDPGT	37..483	CDD:278624	110/497 (22%)
ugt-25	NP_491438.1	egt	1..477	CDD:223071	114/512 (22%)
ugt-25	NP_491438.1	UDPGT	29..530	CDD:278624	118/539 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	172	1.000	Inparanoid score	I2735
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.860