Protein Alignment Ugt301D1 and UGT3A2

DIOPT Version :10

• Sequence 1: NP_609882.1
• Gene: Ugt301D1 / 35105
• FlyBaseID: FBgn0032684
• Length: 530
• Species: Drosophila melanogaster
• Sequence 2: XP_011512290.1
• Gene: UGT3A2 / 167127
• HGNCID: 27266
• Length: 550
• Species: Homo sapiens
• Alignment Length: 585
• Identity: 163/585 - (27%)
• Similarity: 264/585 - (45%)
• Gaps: 119/585 - (20%)

  Fly    23 AGSRILFMGPFPAP------------------SHWLWLEHFQNDLLRQGHHVTSVNN-------- 61
            ||.|:|.:..|..|                  ||:|.::.....|...||:||.:|:
Human     2 AGQRVLLLVGFLLPGVLLSEAAKILTISTVGGSHYLLMDRVSQILQDHGHNVTMLNHKRGPFMPG 66

  Fly    62 ------HPTKHP------------------HENLTEII--ISPSFDIPKHFPKENIFSMQ----- 95
                  ..:::|                  .|...::|  ::|. |..:.|.|...|.::
Human    67 LSDSPASASRYPRILYLQKYCQFGLKDFKKEEKSYQVISWLAPE-DHQREFKKSFDFFLEETLGG 130

  Fly    96 ---FVSDFNNLELWWTIGLMTTEHAFKDPKVKKLIES-KDDHYDLVIIEQFFHEAFLM---FGKR 153
               |.:..|.||.   :.|..:....:    |.:::| |::::|:||:|.|.:..||:   .||.
Human   131 RGKFENLLNVLEY---LALQCSHFLNR----KDIMDSLKNENFDMVIVETFDYCPFLIAEKLGKP 188

  Fly   154 FNCPVVT-IGTMGYADNIDHAMGILTPWSLIPHLLLSHTDRMTFGQRAYNAYLSLYDAVMRRWVY 217
            |...:.| .|::.:        |:..|.|.:|......||.|.|..|..| :|..:....|
Human   189 FVAILSTSFGSLEF--------GLPIPLSYVPVFRSLLTDHMDFWGRVKN-FLMFFSFCRR---- 240

  Fly   218 LPKMQKLAEKYFQGSI-----EGPLPNVLDLERNISLVLINAHRSIDLPRPSMPGLIDVGGAHIQ 277
                |:..:..|..:|     ||..|.:..|.....|..||:..:.|..||.:|..:.|||. ::
Human   241 ----QQHMQSTFDNTIKEHFTEGSRPVLSHLLLKAELWFINSDFAFDFARPLLPNTVYVGGL-ME 300

  Fly   278 KP-KQLPTDLQNFLDN-ATYGVIYFSMGSYVKSTDLPQEKTALILK----AFGQLKQQVIWK--- 333
            || |.:|.||:||:.. ...|.:..::||.|.:...|:     |.|    ||..|.|.||||
Human   301 KPIKPVPQDLENFIAKFGDSGFVLVTLGSMVNTCQNPE-----IFKEMNNAFAHLPQGVIWKCQC 360

  Fly   334 --FENDSIGDLPSNVMIKKWMPQNDILAHPNVKLFITHGGIFGTQEGIYWGVPMLCVPLYGDQHR 396
              :..|.  .|.:||.|..|:||:|:||||:::||:||||.....|.|..||||:.:||:|||..
Human   361 SHWPKDV--HLAANVKIVDWLPQSDLLAHPSIRLFVTHGGQNSIMEAIQHGVPMVGIPLFGDQPE 423

  Fly   397 NTIKSVREGYARSLVFSKLTTDDLVRNIETLINDPQYKRSALEVSQRFRDNPIHPLDEATFWIEY 461
            |.::...:.:..|:...||..:.|...::.::.|.:||.:|:..|...|.:|:.|......||::
Human   424 NMVRVEAKKFGVSIQLKKLKAETLALKMKQIMEDKRYKSAAVAASVILRSHPLSPTQRLVGWIDH 488

  Fly   462 IIRHRGARHLKSHGAFIPLHQYLLLDVLGCLLLGAFL-AIWLPWRMIRRVHKWWLKGESSNKLNE 525
            :::..||.|||.:....|.|:..||||. ..|||..| .:||..::: .:..|||:|  :.|:.|
Human   489 VLQTGGATHLKPYVFQQPWHEQYLLDVF-VFLLGLTLGTLWLCGKLL-GMAVWWLRG--ARKVKE 549

  Fly   526  525
            Human   550  549

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt301D1	NP_609882.1	Glycosyltransferase_GTB-type	37..483	CDD:471961	141/508 (28%)
UGT3A2	XP_011512290.1	Glycosyltransferase_GTB-type	23..518	CDD:471961	145/528 (27%)