DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt301D1 and Ugt1a6

DIOPT Version :9

Sequence 1:	NP_001246079.1	Gene:	Ugt301D1 / 35105	FlyBaseID:	FBgn0032684	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_001034780.1	Gene:	Ugt1a6 / 113992	RGDID:	620949	Length:	530	Species:	Rattus norvegicus

Alignment Length:	525	Identity:	142/525 - (27%)
Similarity:	249/525 - (47%)	Gaps:	83/525 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 SHWLWLEHFQNDLLRQGHHVTSVNNHPTKHPHENLTEIIISPSFDI----PKHFPKENIFSMQFV 97
            ||||.::.....|..:||.:                 :::.|..::    .|::.:::     |.
  Rat    36 SHWLSMKEIVEHLSERGHDI-----------------VVLVPEVNLLLGESKYYRRKS-----FP 78

  Fly    98 SDFNNLELWWTIGLMTTEH-AFKDPKVKKLIESKDDHYDLVIIEQFFHE-----------AFL-- 148
            ..:|..||..........| |...|.:..|.|.::   ::::|:..|..           :||
  Rat    79 VPYNLEELRTRYRSFGNNHFAASSPLMAPLREYRN---NMIVIDMCFFSCQSLLKDSATLSFLRE 140

  Fly   149 -MFGKRFNCPVVTIGTM--------------GYADNIDHAMG-ILTPWSLIPHLLLSHTDRMTFG 197
             .|...|..|.:..|.:              |:..:::|.:| ..:|.|.:|......:|.|||.
  Rat   141 NQFDALFTDPAMPCGVILAEYLKLPSVYLFRGFPCSLEHMLGQSPSPVSYVPRFYTKFSDHMTFP 205

  Fly   198 QRAYNAYLSLYDAVMRRWVYLPKMQKLAEKYFQGSIEGPLPNVLDLERNISLVLINAHRSIDLPR 262
            ||..|...::.:..:...:| .|.:.||....:..:..|.     |.:| ||.|:......:.||
  Rat   206 QRLANFIANILENYLYHCLY-SKYEILASDLLKRDVSLPA-----LHQN-SLWLLRYDFVFEYPR 263

  Fly   263 PSMPGLIDVGGAHIQKPKQLPTDLQNFLD-NATYGVIYFSMGSYVKSTDLPQEKTALILKAFGQL 326
            |.||.:|.:||.:.:|...|..:.:.::: :..:|::.||:||.|  :::|::|...|.:|.|::
  Rat   264 PVMPNMIFIGGTNCKKKGNLSQEFEAYVNASGEHGIVVFSLGSMV--SEIPEKKAMEIAEALGRI 326

  Fly   327 KQQVIWKFENDSIGDLPSNVMIKKWMPQNDILAHPNVKLFITHGGIFGTQEGIYWGVPMLCVPLY 391
            .|.|:|::......:|..|.::.||:||||:|.||..:.||||.|..|..|||..||||:.:||:
  Rat   327 PQTVLWRYTGTRPSNLAKNTILVKWLPQNDLLGHPKARAFITHSGSHGIYEGICNGVPMVMMPLF 391

  Fly   392 GDQHRNTIKSVREGYARSLVFSKLTTDDLVRNIETLINDPQYKRSALEVSQRFRDNPIHPLDEAT 456
            |||..|..:....|...:|...::|.|||...::|:||:..||.:.:.:|...:|.||.|||.|.
  Rat   392 GDQMDNAKRMETRGAGVTLNVLEMTADDLENALKTVINNKSYKENIMRLSSLHKDRPIEPLDLAV 456

  Fly   457 FWIEYIIRHRGARHLKSHGAFIPLHQYLLLDVLGCLLLGAFLAIWLPWR--------------MI 507
            ||:||::||:||.||:.....:..:||..|||:|.||......:::.::              .:
  Rat   457 FWVEYVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAIVLTVVFIVYKSCAYGCRKCFGGKGRV 521

  Fly   508 RRVHK 512
            ::.||
  Rat   522 KKSHK 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt301D1	NP_001246079.1	egt	12..483	CDD:223071	132/480 (28%)
Ugt301D1	NP_001246079.1	UDPGT	37..483	CDD:278624	132/480 (28%)
Ugt1a6	NP_001034780.1	egt	14..504	CDD:223071	140/501 (28%)
Ugt1a6	NP_001034780.1	UDPGT	26..521	CDD:278624	140/518 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	256	1.000	Domainoid score	I1959
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	275	1.000	Inparanoid score	I2882
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm9018
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.860