DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt301D1 and ugt5b2

DIOPT Version :9

Sequence 1:	NP_001246079.1	Gene:	Ugt301D1 / 35105	FlyBaseID:	FBgn0032684	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_001170970.2	Gene:	ugt5b2 / 100415799	ZFINID:	ZDB-GENE-100406-4	Length:	531	Species:	Danio rerio

Alignment Length:	525	Identity:	149/525 - (28%)
Similarity:	256/525 - (48%)	Gaps:	36/525 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 QLQWKCWMLIFLIGLLEFGAGSRILFMGPFPAPSHWLWLEHFQNDLLRQGHHVTSVNNHPTKH-- 66
            |:.|...:.:.|..:.....|..::|  |... |||:.:......|..:||.||.:....:.:
Zfish     7 QVIWPITLTLLLPSVPVAQCGKVLVF--PVDG-SHWVNMNILVEALSAKGHDVTVMRTASSCYIK 68

  Fly    67 ---PHENLTEIIISPSF--DIPKHFPKENIFSMQFVSDFNNLEL---WWTIGLMTTE-------H 116
               ||.....:.....:  ::.:.|....:..::..|.:.:|:|   .|...|...|       :
Zfish    69 EFSPHYTSINLKSKGGYNKEVLEQFASRIMHILRDGSTWGHLKLQADMWQSFLKIFEAEREMIVN 133

  Fly   117 AFKDPKVKKLIES-KDDHYDLVIIEQFFHEAFLMFGKRFNCPVV-TIGTMGYADNIDHAMGILTP 179
            ..:|   ::|::| ||..|||::.:.......:: |.....|:| .:...||  |..|.....:|
Zfish   134 MIED---QQLMQSLKDAKYDLILTDPNMFGGVIL-GHYLKLPMVYNVRWAGY--NEAHFSIAPSP 192

  Fly   180 WSLIPHLLLSHTDRMTFGQRAYNAYLSLYDAVMRRWVYLPKMQKLAEKYFQGSIEGPLPNVLDLE 244
            .|.:|...|..:|||:|.||.||..:.::..:....|..|....|||::.     ||..:.|.|.
Zfish   193 LSYVPMPSLELSDRMSFLQRVYNVVMYIFIEIGAALVISPINDALAERFI-----GPGTSFLSLV 252

  Fly   245 RNISLVLINAHRSIDLPRPSMPGLIDVGGAHIQKPKQLPTDLQNFLDNA-TYGVIYFSMGSYVKS 308
            :...|.|.......:.|||:||.:|.:.|...:..|.||.||::|:.:: .:|||..|:|:.:..
Zfish   253 QGADLWLHRVDFVFEYPRPTMPNVIYMAGFQCKPSKPLPQDLEDFVQSSGDHGVIIMSLGTLIDK 317

  Fly   309 TDLPQEKTALILKAFGQLKQQVIWKFENDSIGDLPSNVMIKKWMPQNDILAHPNVKLFITHGGIF 373
              ||.:....|.:||.:|.|::||:::......|.:|.:|..||||||:|.||..:.|:.|||..
Zfish   318 --LPDDVAEAIAEAFAELPQKIIWRYKGKRPSALGNNTLIMDWMPQNDLLGHPKTRAFVAHGGTN 380

  Fly   374 GTQEGIYWGVPMLCVPLYGDQHRNTIKSVREGYARSLVFSKLTTDDLVRNIETLINDPQYKRSAL 438
            |.||.||.|||::...|..||..|..|....|.|:::.|:.:..:..:..::.::.||.|:.:..
Zfish   381 GIQEAIYHGVPIIGFGLIFDQPDNLSKMRVRGAAKNVDFATMNKESFLTTVKEVLYDPSYRENMQ 445

  Fly   439 EVSQRFRDNPIHPLDEATFWIEYIIRHRGARHLKSHGAFIPLHQYLLLDVLGCLLLGAFLAIWLP 503
            .:|:..:|.|:.|||.|.||||:::||:||.||::....:|.:.|..:||:..|:....|.|...
Zfish   446 RLSRLHKDVPVKPLDNAIFWIEFVMRHKGAAHLRTESYKMPWYSYHSVDVILVLISAVSLIILSI 510

  Fly   504 WRMIR 508
            :.:||
Zfish   511 YAVIR 515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt301D1	NP_001246079.1	egt	12..483	CDD:223071	139/490 (28%)
Ugt301D1	NP_001246079.1	UDPGT	37..483	CDD:278624	135/465 (29%)
ugt5b2	NP_001170970.2	egt	12..501	CDD:223071	143/504 (28%)
ugt5b2	NP_001170970.2	UDPGT	27..525	CDD:278624	146/505 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	252	1.000	Domainoid score	I2043
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	252	1.000	Inparanoid score	I3189
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm6444
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.860