DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt301D1 and ugt5d1

DIOPT Version :9

Sequence 1:	NP_001246079.1	Gene:	Ugt301D1 / 35105	FlyBaseID:	FBgn0032684	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_001170967.1	Gene:	ugt5d1 / 100415794	ZFINID:	ZDB-GENE-091118-36	Length:	532	Species:	Danio rerio

Alignment Length:	532	Identity:	162/532 - (30%)
Similarity:	249/532 - (46%)	Gaps:	82/532 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 AGSRILFMGPFPAP-SHWLWLEHFQNDLLRQGHHVTSVNNHPTKHPHENLTEIIISP--SFDIPK 84
            :|.:||.   :|.. |||:.::....:|..:||.:|                 :|.|  |:.|.:
Zfish    26 SGGKILL---YPVDGSHWVNMKVLIEELHSRGHSIT-----------------VIRPKSSWYITE 70

  Fly    85 HFPKENIFSMQ-FVSDFNN----------------------LELWWTI-GLMTTEHAFKDPKVKK 125
            ..|.....::| .|:||.|                      |:|.:.: .:::|.|......|..
Zfish    71 KSPLYTSITIQDNVNDFENFFEDYLSKAMEIERGEGSGLAFLKLQYDLFSMLSTAHEIACKMVSI 135

  Fly   126 LIESK-------DDHYDLVIIEQ-----FFHEAFLMFGKRFNCPVVTIGTMGYADNIDHAMGILT 178
            ::|.|       |:.|||::.:.     .|...:|......|...:|.|.       .|.....:
Zfish   136 ILEDKMLVKKLQDEQYDLMLTDPAIAGGVFLAHYLKLPLVLNVRWITSGE-------GHFAIAPS 193

  Fly   179 PWSLIPHLLLSHTDRMTFGQRAYNAYLSLYDAVMRRWVYLPKMQKLAEKYFQGSIEGPLPNVLDL 243
            |.|.||.....|||:|.|.||..|.....:..:..|:|..|....|.:||.....:     ::.|
Zfish   194 PMSYIPLPGSGHTDKMGFAQRVKNVLFKTFTFLQNRFVVGPHYDILIDKYLDYKTD-----IVGL 253

  Fly   244 ERNISLVLINAHRSIDLPRPSMPGLIDVGGAHIQKPKQLPTDLQNFLDNA-TYGVIYFSMGSYVK 307
            .:...:.|:.|....:.|||:||.::.:||...:..|.||.||:.|..:: .:|.|..|:|:.||
Zfish   254 IQAADIWLMRADFVFEFPRPTMPNIVYMGGFRCKPSKPLPADLEAFAQSSGEHGFIIMSLGTLVK 318

  Fly   308 STDLPQEKTALILKAFGQLKQQVIWKFENDSIGDLPSNV----MIKKWMPQNDILAHPNVKLFIT 368
            |  ||.:....|..||.:|.|:|||:    .:||.||||    :|..||||||:|.|..:|.|:.
Zfish   319 S--LPADMANAIAAAFARLPQKVIWR----HLGDRPSNVGNNTLIVDWMPQNDLLGHSKIKAFVA 377

  Fly   369 HGGIFGTQEGIYWGVPMLCVPLYGDQHRNTIKSVREGYARSLVFSKLTTDDLVRNIETLINDPQY 433
            |||..|.||.|:.|||:|.|||:.||..|.|:...:|..:.|..|:|..:...:.:...:||..|
Zfish   378 HGGTNGVQEAIFHGVPVLGVPLFFDQFDNLIRVQGKGAGKILKLSELNAEAFEQALRESLNDGSY 442

  Fly   434 KRSALEVSQRFRDNPIHPLDEATFWIEYIIRHRGARHLKSHGAFIPLHQYLLLDVLGCLLLGAFL 498
            ||:...:|...||.|:.|||.|.||||::|||:||.||:|....:|.:.|..:||...|.:.|.:
Zfish   443 KRNMQTLSTLHRDQPMRPLDTAIFWIEHVIRHKGATHLRSEFYKMPWYSYHSVDVFLVLFIVAAV 507

  Fly   499 AIWLPWRMIRRV 510
            .:.....:||.|
Zfish   508 CMLSTIAVIRYV 519

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt301D1	NP_001246079.1	egt	12..483	CDD:223071	154/503 (31%)
Ugt301D1	NP_001246079.1	UDPGT	37..483	CDD:278624	150/488 (31%)
ugt5d1	NP_001170967.1	UDPGT	28..527	CDD:278624	161/530 (30%)
ugt5d1	NP_001170967.1	egt	<267..506	CDD:223071	99/244 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	252	1.000	Domainoid score	I2043
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	252	1.000	Inparanoid score	I3189
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm6444
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.760