DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt301D1 and ugt5b3

DIOPT Version :9

Sequence 1:	NP_001246079.1	Gene:	Ugt301D1 / 35105	FlyBaseID:	FBgn0032684	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_001348442.1	Gene:	ugt5b3 / 100415792	ZFINID:	ZDB-GENE-100406-5	Length:	534	Species:	Danio rerio

Alignment Length:	537	Identity:	145/537 - (27%)
Similarity:	257/537 - (47%)	Gaps:	62/537 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LQWKCWMLIFLIGLLEFGAGSRILFMGPFPAPSHWLWLEHFQNDLLRQGHHVTSVNNHPTKHPHE 69
            ::|...:.:.|:.:....:|:.::|  |... |||:.:......|..:||::|.:....:.:..|
Zfish     8 MRWPVTLTLLLVTVPVVESGNVLVF--PVDV-SHWVNMNVLVEALHAKGHNITVMRMADSWYIKE 69

  Fly    70 NLTEIIISPSFDIPKHFPKENI---------FSMQFVSDFNN--------------LELWWT-IG 110
                  .||      |:...|:         |...|||...|              :|:|.| :.
Zfish    70 ------FSP------HYTSVNLKSSGGLSEDFIGPFVSRLMNILREGSTWGRLKLEIEMWQTSLK 122

  Fly   111 LMTTEHAFKDPKV--KKLIES-KDDHYDLVIIEQFFHEAFLMFGKRFNCPVV-----TIGTMGYA 167
            ::..|.......:  ::|::| |...:||::.:...:.. :|.|.....|:|     ||...|
Zfish   123 MIEIEREMITNMIEDQQLMQSLKKAKFDLILTDPAMYGG-VMLGHYLKLPIVYNVRWTIFGEG-- 184

  Fly   168 DNIDHAMGILTPWSLIPHLLLSHTDRMTFGQRAYNAYLSLYDAVMRRWVYLPKMQKLAEKYFQGS 232
                |.....:|.|.:|..:|...|||:|.:|..|..:.:.......::..|....|.|::.
Zfish   185 ----HFAIAPSPLSYVPVPMLEIPDRMSFLERVKNVVMYIITETQIAFLIAPTYNALCERFI--- 242

  Fly   233 IEGPLPNVLDLERNISLVLINAHRSIDLPRPSMPGLIDVGGAHIQKPKQLPTDLQNFLDNA-TYG 296
              ||..|..:|.:...|.|..|....:.|||:||.::.:.|...:..|.||.||::|:.:: .:|
Zfish   243 --GPEVNFGNLVQEADLWLHRADFVFEYPRPTMPNIVYMAGFQCKPSKPLPQDLEDFVQSSGDHG 305

  Fly   297 VIYFSMGSYVKSTDLPQEKTALILKAFGQLKQQVIWKFENDSIGDLPSNVMIKKWMPQNDILAHP 361
            ||..|:|:.:  ..||.:....|.:||.:|.|::||:::......|.:|.::..||||||:|.||
Zfish   306 VIVMSLGTLI--GQLPDDVAEAIAEAFAELPQKIIWRYKGKRPSALGNNTLVMDWMPQNDLLGHP 368

  Fly   362 NVKLFITHGGIFGTQEGIYWGVPMLCVPLYGDQHRNTIKSVREGYARSLVFSKLTTDDLVRNIET 426
            ..:.|:.|||..|.||.||.|||::...|..||..|..|....|.|:::.|:.:..:..::.::.
Zfish   369 KTRAFVAHGGTNGVQEAIYHGVPIIGFGLIFDQPDNLSKMRVRGAAKNVDFATMDKESFLKTVKE 433

  Fly   427 LINDPQYKRSALEVSQRFRDNPIHPLDEATFWIEYIIRHRGARHLKSHGAFIPLHQYLLLDVLGC 491
            ::.||.|:.:...:|:..:|.|:.|||.|.||||:::||:||.||::....:|.:.|..:||:..
Zfish   434 VLYDPSYRENMQRLSRLHKDVPVKPLDNAIFWIEFVMRHKGAAHLRTESYKMPWYSYHSVDVILV 498

  Fly   492 LLLGAFLAIWLPWRMIR 508
            |:....|.|...:.:||
Zfish   499 LISAVSLIILSIYAVIR 515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt301D1	NP_001246079.1	egt	12..483	CDD:223071	136/503 (27%)
Ugt301D1	NP_001246079.1	UDPGT	37..483	CDD:278624	132/478 (28%)
ugt5b3	NP_001348442.1	UDPGT	27..531	CDD:278624	143/518 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	252	1.000	Domainoid score	I2043
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	252	1.000	Inparanoid score	I3189
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm6444
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.860