DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt301D1 and ugt2b5

DIOPT Version :9

Sequence 1:	NP_001246079.1	Gene:	Ugt301D1 / 35105	FlyBaseID:	FBgn0032684	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_001170816.2	Gene:	ugt2b5 / 100384902	ZFINID:	ZDB-GENE-100402-3	Length:	527	Species:	Danio rerio

Alignment Length:	525	Identity:	145/525 - (27%)
Similarity:	259/525 - (49%)	Gaps:	45/525 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 MLIFLIGLLEFGAGSRILFMGPFPAPSHWLWLEHFQNDLLRQGHHVT-----------SVNNHPT 64
            ::.||..|..|.||.....:..:...|||:.|:...:.||.:||:||           :..:...
Zfish     4 VVCFLSLLTVFSAGQCGNILVWYTEGSHWINLKIVLDTLLDRGHNVTVLVPDGALFMKAKESDRF 68

  Fly    65 KHPHENLTEIIISPSFDIPKHFPKENIFSMQFVSDFNNLELWWTIGLMTTEH----------AFK 119
            .:.|.::::    .:.|:...|.:...||:..:.:.:.||:......:.::|          ..|
Zfish    69 SYQHFSVSK----SAQDMQDFFDELMRFSVFEMDNSSFLEIQMKFFNLGSQHQDMSLSYCDGILK 129

  Fly   120 DPK-VKKLIESKDDHYDLVIIEQFFHEAFLMFGKRFNCPVVTIGTMGYADNIDHAMG-ILTPWSL 182
            .|: :.||.:.|   :|:|:.:..:..:.:: .:..|.|:|.......|...:...| |..|.|.
Zfish   130 SPELMDKLKKGK---FDVVLSDPMYPCSDIV-AEELNVPLVYTFRFSVAHAAERMCGQIPAPPSY 190

  Fly   183 IPHLLLSHTDRMTFGQRAYNAYLSLYDAVMRRWVYLPKMQKLAEKYFQGSIEGPLPNVLDLERNI 247
            :|..:...||:|:|.:|.:|....|....:.|.:: .:......:||     |...:..::....
Zfish   191 VPGAMSKLTDKMSFTERIFNMLFYLSQDTLSRLIW-RRFDNYYTEYF-----GRSTSYCEMMGKA 249

  Fly   248 SLVLINAHRSIDLPRPSMPGLIDVGGAHIQKPKQLPTDLQNFLDNA-TYGVIYFSMGSYVKSTDL 311
            .:.||..:...:.|||.:|....:||.|....|.||.|::.|:.:: ..|::.|::||.:..  :
Zfish   250 DIWLIRTYWDFEFPRPFVPNFKYIGGLHCTPAKPLPKDMEEFVQSSGDDGIVVFTLGSMIDK--V 312

  Fly   312 PQEKTALILKAFGQLKQQVIWKFENDSIGDLPSNVMIKKWMPQNDILAHPNVKLFITHGGIFGTQ 376
            |:|.:..|..|..|:.|:|:|::..:....|..|..|.||:||||:|.||..:.||||||..|..
Zfish   313 PKEMSNRIASALAQIPQKVLWRYGGEKPDTLGENTRIYKWIPQNDLLGHPKTRAFITHGGTNGVY 377

  Fly   377 EGIYWGVPMLCVPLYGDQHRNTIKSVREGYARSLVFSKLTT---DDLVRNIETLINDPQYKRSAL 438
            |.||.||||:.:||:|||..|.:.....  |.::|...:.:   .:||..:.|:||||.||.:|:
Zfish   378 EAIYHGVPMVGIPLFGDQPDNMVHMTTR--AAAVVVDSIKSMQPQELVDKLNTVINDPSYKENAM 440

  Fly   439 EVSQRFRDNPIHPLDEATFWIEYIIRHRGARHLKSHGAFIPLHQYLLLDVLGCLLLGAFLAIWLP 503
            .:|:...|.|:.||||:.||||:::|::||:||:.....:..:||..|||...|.....|.:::.
Zfish   441 RLSRIHHDRPMKPLDESVFWIEFVMRNKGAKHLRVEAHNLTWYQYHCLDVFAFLTTVLTLVLYIC 505

  Fly   504 WRMIR 508
            ::|.:
Zfish   506 FKMAK 510

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt301D1	NP_001246079.1	egt	12..483	CDD:223071	137/497 (28%)
Ugt301D1	NP_001246079.1	UDPGT	37..483	CDD:278624	131/472 (28%)
ugt2b5	NP_001170816.2	UDPGT	20..523	CDD:278624	139/509 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	252	1.000	Domainoid score	I2043
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	252	1.000	Inparanoid score	I3189
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm6444
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.860