DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt301D1 and ugt5e1

DIOPT Version :9

Sequence 1:	NP_001246079.1	Gene:	Ugt301D1 / 35105	FlyBaseID:	FBgn0032684	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	XP_005166829.1	Gene:	ugt5e1 / 100002993	ZFINID:	ZDB-GENE-081105-106	Length:	590	Species:	Danio rerio

Alignment Length:	531	Identity:	160/531 - (30%)
Similarity:	255/531 - (48%)	Gaps:	67/531 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 MLIFLIGLLEFGAGSRILFMGPFPAP-SHWLWLEHFQNDLLRQGHHVTSVNNHPTKHPHEN---L 71
            ::.|:..|.......:||.   :|.. ||||.:.....:|.::||.:|.|.:..:.:..||   .
Zfish    68 LVAFIWSLPSLSLAGKILV---YPVDGSHWLNMNILLQELHQRGHKLTVVRSANSWYIPENATHY 129

  Fly    72 TEIIIS----PSFDIPKH---FPKENIFSMQFVSDFNNLELWWT--------IGLMTTEH----- 116
            |.|.|.    .|.:.||:   |.|.||...:.....      |:        |.|:...|
Zfish   130 TSITIQVNHLSSLEDPKYMASFLKRNIDIQRGKGSI------WSFLALQKEIITLLEESHRSTAE 188

  Fly   117 ----AFKDPK-VKKLIESKDDHYDLVIIEQFFHEAFLMFGKRFNCPVVTIGTMGYADNIDHAMGI 176
                ..:|.| :|.|.|||   |||::.:..|....:: |.....|:|.  .:.:..|.:....|
Zfish   189 MVRVVLEDEKLIKTLKESK---YDLMLTDPGFAGGVIL-GAYLGLPMVF--NVRWITNAEGHFAI 247

  Fly   177 L-TPWSLIPHLLLSHTDRMTFGQRAYNAY---LSLY-DAVMRRWVYLPKMQKLAEKYFQGSIEGP 236
            . :|.|.||.:....||:|:|..:..|..   :..| |.::.|    |..|.:..||..     |
Zfish   248 APSPLSYIPTIGSRVTDKMSFANKLKNIMHFGIGQYIDHMLTR----PLYQGVISKYID-----P 303

  Fly   237 LPNVLDLERNISLVLINAHRSIDLPRPSMPGLIDVGGAHIQKPKQLPTDLQNFLDNA-TYGVIYF 300
            ..||..|.:...|.|:......:.|||:||.::.:||...:..|.||.:|..|:::: .:||:..
Zfish   304 NTNVYALIQGADLWLMRVDFVFEFPRPTMPNVVYIGGFQCKPSKPLPDELNKFVESSGEHGVVIM 368

  Fly   301 SMGSYVKSTDLPQEKTALILKAFGQLKQQVIWKFENDSIGDLPSNVMIKKWMPQNDILAHPNVKL 365
            |:|:.:.|  |..:.:.::..||.||.|:|||:...:....|.:|.::..|:||||:|.||..|.
Zfish   369 SLGTLLGS--LVPDISEIVASAFAQLPQKVIWRHVGEKPSTLGNNTLVVDWLPQNDLLGHPKTKA 431

  Fly   366 FITHGGIFGTQEGIYWGVPMLCVPLYGDQHRNTIKSVREGYARSLVFSKLTTDDLVRNIETLIND 430
            |:||||..|..|.||.|||||.:||..||..|.|:....|.||.|..:.|..|.|.:.::.::::
Zfish   432 FVTHGGTNGIYEAIYHGVPMLGLPLIFDQFDNIIRLEARGVARMLDVATLDVDILTQALKDILDE 496

  Fly   431 PQ-YKRSALEVSQRFRDNPIHPLDEATFWIEYIIRHRGARHLKSHGAFIPLHQYLLLDVLG---- 490
            .| |:::..::|...||.|:.|||.|.||:|:::||:||.||::....:|.:.|..||||.
Zfish   497 KQSYQKNMRKMSSLHRDTPLKPLDSAIFWLEFVMRHKGAAHLRTESYKLPWYSYHCLDVLALIMS 561

  Fly   491 -CLLLGAFLAI 500
             |...|..|.:
Zfish   562 LCTAAGLLLIL 572

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt301D1	NP_001246079.1	egt	12..483	CDD:223071	152/506 (30%)
Ugt301D1	NP_001246079.1	UDPGT	37..483	CDD:278624	147/480 (31%)
ugt5e1	XP_005166829.1	UDPGT	82..586	CDD:278624	158/517 (31%)
ugt5e1	XP_005166829.1	egt	<324..550	CDD:223071	84/227 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	252	1.000	Domainoid score	I2043
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	252	1.000	Inparanoid score	I3189
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm6444
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.860