DRSC/TRiP Functional Genomics Resources

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Protein Alignment kon and frem2b

DIOPT Version :9

Sequence 1:NP_001260539.1 Gene:kon / 35104 FlyBaseID:FBgn0032683 Length:2381 Species:Drosophila melanogaster
Sequence 2:NP_001131133.1 Gene:frem2b / 566673 ZFINID:ZDB-GENE-081119-4 Length:3116 Species:Danio rerio


Alignment Length:2372 Identity:494/2372 - (20%)
Similarity:851/2372 - (35%) Gaps:676/2372 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly   290 HRVFLRYNAAIAELSL--DDATSGYRGTHANETKASINLEKSVFFGGVQEEMRRRLI---SKGLR 349
            ||.....:..:..|:|  |.::.|:.         |:.|..     |::.|:....|   :.|:|
Zfish    10 HRRSFHVHLFVITLTLIRDASSQGFE---------SLGLTY-----GLRSELSEDAILVANNGIR 60

  Fly   350 -----------INEISFK-----GCMRDILVNDLPLGFAEMTISRSLALNCLWKYPCVEYNP--- 395
                       ||::..:     .|...:|.|| ||......:|..       |:|| |:.|   
Zfish    61 VPFGRSVFIDPINDLVIQVQPGDKCTVTVLDND-PLSQRPGQLSPK-------KFPC-EFGPNDV 116

  Fly   396 ---CLKSGICSQHGVDGFICYCDQSYCIKADFQGPFK-IFTETSPELELLYVSPMQLLEGGTAFL 456
               ...|...|:..|...:.|..|:..:...|....: |||    :||:|......::|......
Zfish   117 KYSHFGSRSPSKDRVRLQLRYDTQTDTVIIPFMMEVEVIFT----QLEILTKHMPVVVEKLLGLS 177

  Fly   457 SP---HFIDIILD----LRRYPSLNEQSIIFHVVHQPKYGQLLQYSAEKAIFVPCRTFNLVDLAT 514
            :|   ..::...|    |.:..||...|.:      |:||:|:. :.:....|.|..|..:|   
Zfish   178 NPIDKKILEFTYDRNAHLCKVTSLASGSSL------PRYGKLVD-NGKLGKPVDCDEFVRMD--- 232

  Fly   515 DKLKYVHNGQENFNDHATLDMQIFGDVHKIPENILGKHRFLLHANIT--PINDPPQLRLHSHKIL 577
              ::|.|.......:...:.|.:  ::.....|:|.:..|.:...|.  ..|..|:....:..::
Zfish   233 --IRYQHTFAHRSPNRDYIPMYL--ELQDKEANVLKQEFFQIVVLIKEGEENTAPKPSFVAMMMM 293

  Fly   578 RVIEGIERVLDVDLFNIDDPDSEPGNLIYTILPTQSPQETFGCFIVG----GATTSAFSQAEVNV 638
            .|.:.:...:..|:...:|.:|.|.:||:.|....|.:|.   :||.    ....::|.||::..
Zfish   294 EVDQFVMTAITHDMLAAEDVESNPDDLIFNITSPLSFEEG---YIVSTDDRNLPITSFYQADLKE 355

  Fly   639 GKVSY---LYNSTTAESFSYELQLQVSDGIETSETVYLPVSVHPLELR---LVNNTGLIMIHKSS 697
            .|::|   ..:|.....|..|.::..::|..:....:: :.|.|:...   :..|||.::....|
Zfish   356 LKIAYKPPAVDSDAERIFQIEFEVVDTEGAISDPFAFM-IVVKPMNTLAPVVTRNTGQLLYEGQS 419

  Fly   698 LPISTA-NLSIGTNAVDDHID-IRYDIVKAPQHGVLQRLRQIDGSWVNVDWFSDSQLLLGHIRYL 760
            .|:|:: ||.|..   :|::| ::..::...:||.|..|    ||  ...:|:.:.|.:|.:.|.
Zfish   420 RPLSSSQNLQISD---EDNLDYVQITVINGLRHGELTVL----GS--RQKFFTPADLDVGSVIYQ 475

  Fly   761 HSSDFPWQDEFKFIASFGFVTTQTFDFRITFTRLRITSTRPSQISING------------SREIL 813
            |.....:.|...|..:.|....: |.|.||...   |...|..|:.|.            |...|
Zfish   476 HDGSDTYSDNIIFRMTDGKNEVE-FLFPITVVP---TDDEPPIINANTGLVLFKNQMMPISSLTL 536

  Fly   814 LTSDVLSYETT-------PIGSFARSVIYKITKPT-----RYGG---IYVEGSRKAAKKLDSFTQ 863
            ..:|:.|.::|       |..:....::.:...|.     |:..   :|       .|.:..:.|
Zfish   537 SAADIDSEDSTIKFIMVPPYSNIGEVILRQSDAPEDPSTWRFNAEDEMY-------EKVVTEWLQ 594

  Fly   864 QDIEKRRIRYQ---THHTSYSSFSDHLEFVVSVAECDD----------VAGVLEINYRPPDELIN 915
            .||.:.::.|:   .|:|  .:..|  :||..|.:.:|          :..||.|:..|||.   
Zfish   595 HDITEGKLFYRHIGPHNT--KTIMD--QFVFRVQDDNDPPNQSGENSFIIKVLPIDDIPPDM--- 652

  Fly   916 KLGYQNHEPLQVQEGERALITKNHFGIRFNIYES----LQFQVSLSP------EHGVICKYDEQT 970
               |.. ..||:...|..|.......:|:...:|    |::.::..|      ..|::.......
Zfish   653 ---YPG-TTLQMTVHEYHLTFFRKKFLRYTDLDSDDRDLKYTITQPPADTDENSPGILGSIVLTE 713

  Fly   971 GLTTPVEMFTLEQLFRNDIYYCHDDTE------------STRDTFELLILSGDETDLQFVSNMEV 1023
            ..|..|..||..|:..:.|.|...|.|            ...||      :|:.....|.    :
Zfish   714 SPTLEVNEFTQAQINHHKIAYKPPDLELGITPHVVQFQYKVEDT------AGNSASGVFT----I 768

  Fly  1024 HIKLVNDNEPYRTAIERVFHVVRNGIRTLNPTVLQYLDADVNTN-----------HTDIHYIHVS 1077
            .::.|::..|..|  ...|.:...|:..:....|...|||.:::           |..:.|....
Zfish   769 FLQPVDNKPPQIT--NTGFTLQERGMHVITRAELDTTDADTDSSQILFTITQPPQHGQVKYTFTD 831

  Fly  1078 STNGAFYKSGHYIDSFTQDDIANRRIMFQHTGADSGTASFI---VTDREHEVNGLLEIRASDPFV 1139
            .|.|         :||..|||:|.||.:.|.| |..|:.|.   |:|..|.|.  :.:|.|   |
Zfish   832 MTKG---------NSFNLDDISNGRISYIHNG-DESTSDFFQLDVSDGVHVVT--ITVRIS---V 881

  Fly  1140 SMMATNASIVQ-----EGKFV-VLKNKDFILETNLDMKLDE------IYYEVIKPPSYGILMY-- 1190
            ..:...|.|:.     .|.:: ||:|....:.||:....||      :.:.|..||.:|.::.  
Zfish   882 KPIDDEAPIISLPEGTIGSYIDVLENGATEITTNVIQGRDEDTDDLRLTFIVEDPPVFGEILVNG 946

  Fly  1191 --LSRANEGE--NGTTIYKATNYTSLS--------NFTHLDIERERLVYWNTEIASMDKVRYRVH 1243
              .:|..:.:  :|..:| |.|...:.        |.|..|:..|    |......:..||.:|.
Zfish   947 VPSNRFTQADIISGLVVY-AHNTGEIGLATKQDFFNLTLTDMSDE----WTVGGNKIKGVRVQVT 1006

  Fly  1244 IKNITAEGEVMFRIYPSAYWEPLQVKQNHTLYVEESTSVL----ISRDVLEVVHPNISPGDITFL 1304
            |..:.::.       |..:..|      ..:.||...:|:    ||.:.::.  ||   .|:...
Zfish  1007 ILPLDSQA-------PEVFVGP------QFIVVEGEKNVIAISHISANDIDT--PN---DDLLCT 1053

  Fly  1305 VTSSPMHGYLEMQSMSFDDEYN-----CKVFDQSSVNTEKMFYIQA---GVNQSTDYFVFDVTNG 1361
            :...|..||:|..|.:...|.:     ...|....:....::|:|:   ||....|.|.|..::|
Zfish  1054 IIVQPTSGYVENISPAPGSEKSRSGIAISAFTIKDIRENHIYYVQSIHKGVEPVEDRFTFRCSDG 1118

  Fly  1362 ITWLRQLMIKIVIIPE-----KLYMHSNIISVVEGKTVQ-----LNPTDIQ-PYSEYYRGKILEY 1415
            |.:..:....|||||.     ::||...:  |:||..:.     ||..|.. |..|      |.:
Zfish  1119 INFSERHFFPIVIIPSNDEKPEIYMREFV--VMEGMNIVIDTPILNGADADVPADE------LTF 1175

  Fly  1416 IVTITPSSGHVL----AGNSKVKRFTQKQL-EQGSIQYVHNGSENATDSITLVAMARNKESVPFE 1475
            |::..|..|.:|    :|...|..||.:|: |..||.|.|:.||...||..:: :...|.:|...
Zfish  1176 IISKPPKHGFILNQLTSGTIPVTNFTLEQIREASSIVYEHDDSETTEDSFEIL-LTDGKFTVEKT 1239

  Fly  1476 LEFAVVQVNDEEPMMVTNTGLQVWNGGRYVIKNTDLLAQDYDTPPENLTFVVNHIYGGYLARKSA 1540
            :...|:.|:||.|.|..|.||::..|...:|.|..|.|.|.||....||:::.  ||        
Zfish  1240 VMIMVILVDDETPRMAINDGLEIEIGEVKIINNKVLKATDLDTEDSTLTYIIR--YG-------- 1294

  Fly  1541 PHQKIEHFTQAQINLEEIYFMHDSNSRRNELSFVVTDGLFNTTTQMLNIEIKPIEILAEHNENLH 1605
            |:|.|                         |......|||...|..:|                 
Zfish  1295 PNQGI-------------------------LQKRTPFGLFENITVGMN----------------- 1317

  Fly  1606 VFPLTKKQILRDYLHFKCSDEEREIRYNITVPPSLGRIVNEFIDNGFTKEVSEFTQNDVDNGHIF 1670
                                                                 ||||:||...|.
Zfish  1318 -----------------------------------------------------FTQNEVDQDIIM 1329

  Fly  1671 YEHTAVIMEFRTNDSFYFDVVAERSDRLLNQKFNIEISVSSGGLLRFLP--VNK-LNVDEGGSVP 1732
            |.|..   :....|...|| |.:..:.|:::.|.:.:    ||:....|  ::| :::.|||.|.
Zfish  1330 YIHNG---QEGVRDLIKFD-VTDGINPLIDRYFYVTV----GGIDMVFPDVISKGVSLKEGGRVT 1386

  Fly  1733 IKLDFSKILEYLKTKAGINNPE--LFIEAIQKPTHGNIGLGHEFKHMQRYHPSDFFTK------K 1789
            :..|.....:|       |:|:  |.....:.|..|::.. .:...|    |...||:      |
Zfish  1387 LTTDLLSTSDY-------NSPDEHLVFTITRAPVRGHLEC-TDIPSM----PISSFTQLQLAGNK 1439

  Fly  1790 VYYIHDHSDTLEDTILMSVY---LTQG--NIFLCNLTIPVSINPI-NDQPFHLVTHLPQMTVVEG 1848
            :||||    |.:|.:.|..:   :|.|  .:|   .|..|||..: |.:|   |..:..:.|.||
Zfish  1440 IYYIH----TADDEVKMDSFEFEVTDGYNPVF---RTFRVSITDVDNKKP---VVTIHGLIVNEG 1494

  Fly  1849 ENRTITRNDLLTEDADTPPEEIIYDVMSGPTLGVL-----RKITNDGRPEDLLAFSNQFTQADIN 1908
            |::.||..:|..||.||..:.:.:.:...|..|.|     |.:|:             ||:.|:|
Zfish  1495 ESKLITPFELTVEDRDTADQLLKFTITQVPVHGKLLFNNTRSVTS-------------FTKQDLN 1546

  Fly  1909 NDRIIYVHFGMPQ-STTFCFTVSDGQSNPAYEIFTIKIDSIHL--QPSAMQAPV-----KVQQ-- 1963
            .:.|.|.|.|... |.:|.|||:||.....| :|.   |:::.  :|..|:..:     .|.|  
Zfish  1547 ENMIRYKHDGTESASDSFSFTVTDGTHTDFY-VFP---DTVYATRKPQMMKITIYSVDNGVPQVV 1607

  Fly  1964 ----GATTAPMRLDHIG---VSTNVHME-------RLSYNVTNSPLFGIIV--YKHQPTL-RFTQ 2011
                |.|...:...|:|   .|..:..|       .:::.:|.....|.::  .|...|: .|||
Zfish  1608 TNKGGTTLRTLSTGHLGFLITSKTLKAEDRDSPQGAVTFKITVGAEHGYLIDLGKGNATITTFTQ 1672

  Fly  2012 QQLETSQISYMQTD-LNRSNDSFQVSAYVPGTN------------YVAQVDVVMEVEPVIQINDI 2063
            ..::...|.|:..| :|.::|:|..|....|.|            :::......:|:...:..::
Zfish  1673 ADIDDMHICYVLRDGVNATSDTFHFSIEDHGGNKLKNQQFRLNWAWISLEKEYYQVDEESKFLEV 1737

  Fly  2064 VMKEAESSGGKIKLIT------SLDNDNPLSLKLNK---FNPKFVITRMPSTGQIRKIIRSTGLT 2119
            :::. ....|:...::      :.:.|.....|..|   |||                       
Zfish  1738 LLRR-RGYLGETSFVSIGTKDGTAEKDKDFRGKAQKQVQFNP----------------------- 1778

  Fly  2120 TDGQSDRSTNIFSYKELRSGVVYFVPHESVEETEADHDSFDYQLLIKTVQPAQATVSIEYRSRVE 2184
              ||:..|..:    .:.|..:|       |::|.      :|:::.  :|..|.:.....:.||
Zfish  1779 --GQTTASWKV----RIMSDSLY-------EQSEI------FQIVLS--EPVMAALEFPEAAAVE 1822

  Fly  2185 ETE-----TVHLGSAGLSINYLAIGCAIFIVLICLLIVLLILKIRKLRKHKADISKD-------- 2236
            .|:     ||.:.....||.. .||             .|::.:|:    ..|:|::        
Zfish  1823 ITDPEDESTVFIPLTAYSIEE-DIG-------------ELLIPVRR----SGDVSQELMVVCFTQ 1869

  Fly  2237 -------QPPALPCPPDLTSVSPQHH--LHHHHGHH-------------YASSEADSVP------ 2273
                   .|..:....|..|.:.:||  |....|..             |...|:.:|.      
Zfish  1870 QGTAKGTVPTTVLSYSDYISRAEEHHSVLRFDKGETEKQCRVVIIDDSLYEPEESFNVTLSMAMG 1934

  Fly  2274 -------ATGNSTPLPGFSNIPHCKIIPVESYKHEYPDYDPDEEETDDQCDPQQMMLPQRYNPYH 2331
                   :|...|.||...:.|       ..|..|. ||..||.:.                  :
Zfish  1935 GRLGQEFSTARVTILPDADDAP-------VFYFGEI-DYHVDESDG------------------N 1973

  Fly  2332 MEHDAWSSSCDMANDFAGYASVPQSISGSVSS 2363
            :|...|.:..|::.  ||..:|....:..||:
Zfish  1974 VEVRVWRTGSDLSK--AGTVTVRSRKTDPVSA 2003

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
konNP_001260539.1 LamG 30..176 CDD:238058
LamG 211..365 CDD:238058 17/95 (18%)
Cadherin_3 507..664 CDD:292802 31/165 (19%)
Cadherin_3 631..776 CDD:292802 35/152 (23%)
Cadherin_3 747..892 CDD:292802 35/174 (20%)
Cadherin_3 861..1005 CDD:292802 38/178 (21%)
Cadherin_3 979..1121 CDD:292802 38/167 (23%)
Cadherin_3 1093..1242 CDD:292802 45/177 (25%)
Cadherin_3 <1264..1361 CDD:292802 23/108 (21%)
Cadherin_3 1330..1464 CDD:292802 44/152 (29%)
Cadherin_3 1436..1578 CDD:292802 39/142 (27%)
Cadherin_3 1789..1932 CDD:292802 47/154 (31%)
Cadherin_3 2009..2163 CDD:292802 27/175 (15%)
frem2bNP_001131133.1 Cadherin_3 233..361 CDD:292802 25/132 (19%)
Cadherin_3 348..493 CDD:292802 35/154 (23%)
Cadherin_3 462..625 CDD:292802 36/177 (20%)
Cadherin_3 594..735 CDD:292802 33/151 (22%)
Cadherin_3 722..869 CDD:292802 38/168 (23%)
Cadherin_3 838..986 CDD:292802 40/154 (26%)
Cadherin_3 952..1118 CDD:292802 37/188 (20%)
Cadherin_3 1084..1232 CDD:292802 44/156 (28%)
Cadherin_3 1200..1349 CDD:292802 57/258 (22%)
Cadherin_3 1318..1462 CDD:292802 43/167 (26%)
Cadherin_3 1430..1571 CDD:292802 49/163 (30%)
Cadherin_3 1540..1701 CDD:292802 42/164 (26%)
Calx-beta 1719..1806 CDD:295344 16/129 (12%)
Calx-beta 1830..1930 CDD:295344 20/117 (17%)
Calx-beta 1955..2050 CDD:281194 15/77 (19%)
Calx-beta 2077..>2145 CDD:295344
Calx-beta 2198..2289 CDD:295344
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 49 1.000 Domainoid score I11789
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.910

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